View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List MCAF Active Protein Catalog # MBS650020 Unit / Price 0.005 mg / $350 +1 FREE 8GB USB 0.02 mg / $500 +1 FREE 8GB USB 5x0.02 mg / $2,080 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name MCAF, Active Protein Popular Item Full Product Name MCAF, Recombinant, Human (MCP-1, Macrophage/Monocyte Chemotactic and Activating Factor) Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Host Recombinant Human MCP (E Coli). Purity/Purification Highly Purified98% by SDS-PAGE and HPLC analysis. Endotoxin: 0.1ng/ug Form/Format Supplied as a lyophilized powder from 5mM Tris, pH7.6 Biological Activity Determined by its ability to chemoattract human monocytes using a concentration range of 10-100ng/ml. Country of Origin USA Preparation and Storage Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile ddH2O. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Active Protein Note Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product. Other Notes Small volumes of MCAF active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for MCAF active protein Human macrophage/ monocyte chemotactic and activating factor (MCAF) also called human macrophage chemoattractant protein-1 (MCP-1) is an 8.6kD protein containing 76 amino acids residues. It plays an important role in the inflammatory response of blood monocytes and tissue macrophages. Product Categories/Family for MCAF active protein Growth Factors; Cytokines; Growth Factors-MCAF NCBI/Uniprot data below describe general gene information for MCAF. It may not necessarily be applicable to this product. NCBI GI # 29611342 Molecular Weight 8.6kD[Similar Products] TOP NCBI Official Full Name MBD1-containing chromatin associated factor TOP NCBI Summary for MCAF ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009 [PubMed 19106100]).[supplied by OMIM, Nov 2010] TOP UniProt Comments for MCAF ATF7IP: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. Belongs to the MCAF family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 12p13.1Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleusMolecular Function: protein binding; ATPase activity; transcription corepressor activityBiological Process: establishment and/or maintenance of chromatin architecture; viral reproduction; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; DNA methylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcriptional preinitiation complex assembly Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Products associated with MCAF active protein Reference Product PubMed Publications FLNA active protein >12 publications with MCAF and FLNA Pathways associated with MCAF active protein Products by Pathway Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram Focal Adhesion Pathway antibodies Focal Adhesion Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram MAPK Signaling Pathway antibodies MAPK Signaling Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Salmonella Infection Pathway antibodies Salmonella Infection Pathway Diagram Organs/Tissues associated with MCAF active protein Organ/Tissue Name Pubmed Publications Bone Antibodies >13 publications with MCAF and Bone Connective Tissue Antibodies >4 publications with MCAF and Connective Tissue Heart Antibodies >3 publications with MCAF and Heart Muscle Antibodies >3 publications with MCAF and Muscle Brain Antibodies >3 publications with MCAF and Brain Vascular Antibodies >2 publications with MCAF and Vascular Embryonic Tissue Antibodies >2 publications with MCAF and Embryonic Tissue Ear Antibodies >1 publications with MCAF and Ear Kidney Antibodies >1 publications with MCAF and Kidney Umbilical Cord Antibodies >1 publications with MCAF and Umbilical Cord TOP