NP_005399.1
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,986 Da
NCBI Official Full Name
C-C motif chemokine 13
UniProt Protein Name
C-C motif chemokine 13
UniProt Synonym Protein Names
CK-beta-10; Monocyte chemoattractant protein 4; Monocyte chemotactic protein 4; MCP-4; NCC-1; Small-inducible cytokine A13
UniProt Synonym Gene Names
UniProt Entry Name
CCL13_HUMAN
NCBI Summary for MCP-4
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]
UniProt Comments for MCP-4
CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.
Protein type: Secreted, signal peptide; Chemokine; Motility/polarity/chemotaxis; Secreted
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component: extracellular space
Molecular Function: chemokine activity; receptor binding
Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell-cell signaling; eosinophil chemotaxis; immune response; cytoskeleton organization and biogenesis; inflammatory response; chemotaxis; signal transduction
Product References and Citations for MCP-4 recombinant protein
• raised MCP-4 levels in symptomatic carotid atherosclerosis: an inflammatory link between platelet and monocyte activation . Cardiovasc Res, Mar 2010; 10.1093/cvr/cvq044. • monocyte chemoattractant protein-4 (MCP-4) /ccl13 is highly expressed in cartilage from patients with rheumatoid arthritis .Rheumatology, Apr 2006; 45: 421 - 424. • il-4 differentially regulates eotaxin and MCP-4 in lung epithelium and circulating mononuclear cells .Am J Physiol Lung Cell Mol Physiol, Nov 2001; 281: 1288. • monocyte chemoattractant protein (mcp) -4 expression in the airways of patients with asthma. induction in epithelial cells and mononuclear cells by proinflammatory cytokines .Am. J. Respir. Crit. Care Med., Aug 2000; 162: 723 - 732. • eosinophil chemotactic chemokines (eotaxin, eotaxin-2, rantes, monocyte chemoattractant protein-3 (mcp-3), and MCP-4), and c-c chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics .J. Immunol., Dec 1999; 163: 6321 - 6329.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with MCP-4 recombinant protein
Pathways associated with MCP-4 recombinant protein
Diseases associated with MCP-4 recombinant protein
Organs/Tissues associated with MCP-4 recombinant protein
|