NP_034909.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
mast cell protease 4
NCBI Official Synonym Full Names
mast cell protease 4
NCBI Official Synonym Symbols
Mcp4; Mcp-4; MMCP-4; MMCP-4A; MMCP-4B [Similar Products]
NCBI Protein Information
mast cell protease 4; MSMCP; myonase; serosal mast cell protease
UniProt Protein Name
Mast cell protease 4
UniProt Synonym Protein Names
MSMCP; Myonase; Serosal mast cell protease
UniProt Synonym Gene Names
UniProt Entry Name
MCPT4_MOUSE
UniProt Comments for Mcpt4
Function: Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing. Ref.4 Ref.7
Enzyme regulation: Completely inhibited by serine protease inhibitors such as chymostatin, diisopropylfluorophosphate and phenylmethylsulfonyl fluoride, but not by p-tosyl-L-phenylalanine chloromethyl ketone, p-tosyl-L-lysine chloromethyl ketone, pepstatin, E-64, EDTA or o-phenanthroline. Also inhibited by lima bean trypsin inhibitor, soy bean trypsin inhibitor and human plasma alpha1-antichymotrysin.
Subunit structure: Monomer. Ref.4
Tissue specificity: Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells. Ref.4
Disruption phenotype: Mice display an impaired ability to inactivate thrombin or degrade fibronectin in peritoneal cells. Ref.7
Sequence similarities: Belongs to the peptidase S1 family. Granzyme subfamily.Contains 1 peptidase S1 domain.
Biophysicochemical propertiespH dependence:Optimum pH is 9 at high salt concentrations.
Mass spectrometry: Molecular mass is 25187 Da from positions 21 - 246. Determined by MALDI. Ref.4
Sequence caution: The sequence BAB18732.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on Mcpt4
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Diseases associated with Mcpt4 active protein
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