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MDC69 recombinant protein

Scan QR to view Datasheet Catalog #    MBS539609 MDC69 recombinant protein
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MDC69, Recombinant Protein

 Also Known As   

MDC69 protein

 Product Synonym Names    ABCD-1 protein; Macrophage-Derived Chemokine protein; MDC 69; MDC-69 protein; MDC 69 protein; STCP-1 protein; MDC-69; MDC69; CCL22 protein
 Product Gene Name   

MDC69 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    Region of MDC69 protein correspond ing to amino acids GPYGANMEDS VCCRDYVRYR LPLRVVKHFY WTSDSCPRPG VVLLTFRDKE ICADPRVPWV KMILNKLSQ.
 OMIM    602957
 3D Structure    ModBase 3D Structure for O00626
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 Host    Human
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 Purity/Purification    > 98% pure
 Form/Format    Supplied as a lyophilized powder.
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 Protein Type    Recombinant
 Biological Significance    MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells and exerts HIV suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity but retains HIV suppressive activity.
 Bioactivity    Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml.
 Endotoxin Levels    Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
 Expression System    E Coli
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 Preparation and Storage    Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of MDC69 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MDC69 recombinant protein

   Purified recombinant Human MDC69 protein
 Product Categories/Family for MDC69 recombinant protein    Cytokines & Growth Factors
 Applications Tested/Suitable for MDC69 recombinant protein   

User optimized

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NCBI/Uniprot data below describe general gene information for MDC69. It may not necessarily be applicable to this product.
 NCBI GI #    1931581
 NCBI GeneID    6367
 NCBI Accession #    AAB58360.1 [Other Products]
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 UniProt Primary Accession #    O00626 [Other Products]
 UniProt Secondary Accession #    A0N0Q6; B2R4W2 [Other Products]
 UniProt Related Accession #    O00626 [Other Products]
 Molecular Weight    8.0 kDa
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 NCBI Official Full Name    macrophage-derived chemokine
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 22
 NCBI Official Symbol    CCL22 [Similar Products]
 NCBI Official Synonym Symbols   
MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 22
 UniProt Protein Name    C-C motif chemokine 22
 UniProt Synonym Protein Names   
CC chemokine STCP-1; MDC(1-69); Macrophage-derived chemokine; Small-inducible cytokine A22; Stimulated T-cell chemotactic protein 1
 UniProt Gene Name    CCL22 [Similar Products]
 UniProt Synonym Gene Names    MDC; SCYA22 [Similar Products]
 UniProt Entry Name    CCL22_HUMAN
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 NCBI Summary for MDC69    This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]
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 UniProt Comments for MDC69    CCL22: May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine; Secreted

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity

Biological Process: cell-cell signaling; response to virus; immune response; chemotaxis; inflammatory response; signal transduction
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 Research Articles on MDC69    1. The serum CCL22 levels were affected by genetic variations at SNP rs223818. Accordingly, SNP rs223818 may play a role in the susceptibility to breast cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MDC69 recombinant proteinPathways associated with MDC69 recombinant protein
 Reference Product  PubMed Publications
 CCL17 recombinant protein  >367 publications with MDC69 and CCL17
 CCR4 recombinant protein  >232 publications with MDC69 and CCR4
 CCL2 recombinant protein  >99 publications with MDC69 and CCL2
 CCL5 recombinant protein  >92 publications with MDC69 and CCL5
 CCL11 recombinant protein  >60 publications with MDC69 and CCL11
 CCR5 recombinant protein  >42 publications with MDC69 and CCR5
 CCR3 recombinant protein  >29 publications with MDC69 and CCR3
 CCR8 recombinant protein  >25 publications with MDC69 and CCR8
 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram
Diseases associated with MDC69 recombinant proteinOrgans/Tissues associated with MDC69 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >201 publications with MDC69 and Inflammation
 Hypersensitivity Antibodies  >147 publications with MDC69 and Hypersensitivity
 Respiratory Tract Diseases Antibodies  >121 publications with MDC69 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >106 publications with MDC69 and Lung Diseases
 Necrosis Antibodies  >81 publications with MDC69 and Necrosis
 Dermatitis, Atopic Antibodies  >77 publications with MDC69 and Dermatitis, Atopic
 Respiratory Hypersensitivity Antibodies  >65 publications with MDC69 and Respiratory Hypersensitivity
 Liver Diseases Antibodies  >18 publications with MDC69 and Liver Diseases
 Pneumonia Antibodies  >16 publications with MDC69 and Pneumonia
 Cardiovascular Diseases Antibodies  >15 publications with MDC69 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >506 publications with MDC69 and Blood
 Thymus Antibodies  >138 publications with MDC69 and Thymus
 Skin Antibodies  >132 publications with MDC69 and Skin
 Lung Antibodies  >111 publications with MDC69 and Lung
 Bone Antibodies  >49 publications with MDC69 and Bone
 Kidney Antibodies  >13 publications with MDC69 and Kidney
 Eye Antibodies  >10 publications with MDC69 and Eye
 Mouth Antibodies  >3 publications with MDC69 and Mouth
 Pharynx Antibodies  >3 publications with MDC69 and Pharynx
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