Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow MICB  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • MET-Ab1 Antibody
 • EB1+EB2+EB3 (EB1-EB2-EB3) Antibody
 • Syncytin 1 (ERVW-1) ELISA Kit
 • Estriol 3 Antibody
 • 3-Hydroxy-3-methylglutaryl- Coenzyme A Synthase (HMGCS) ELISA Kit
 • CD45RB Antibody
 • RAS guanyl releasing protein 2 (calcium and DAG-regulated) ... ELISA Kit
 • HIF-1alpha Antibody
 • retinoic acid induciblegene - RIG-I-like receptor (RLR) ELISA Kit
 • chemokine (C-C motif) ligand 23 (CCL23) ELISA Kit
 • superoxide dismutase 1, soluble (SOD1) ELISA Kit
 • Kidney Injury Molecule 1 (KIM1) ELISA Kit
 • Chondroitin Sulfate (CS) ELISA Kit
 • IL6 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

MICB recombinant protein :: MHC class I chain-related gene B Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142923 MICB recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,020 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MHC class I chain-related gene B (MICB), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human MHC class I chain-related gene B

 Product Synonym Names    MICB Human; MHC Class-I chain related gene B Human Recombinant; MHC class I polypeptide-related sequence B; MIC-B; MICB; PERB11.2
 Product Gene Name   

MICB recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    180300
 3D Structure    ModBase 3D Structure for Q29980
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    Lyophilized from a concentrated (1mg/ml) solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
Section Bar
 Solubility    It is recommended to reconstitute the lyophilized MICB in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Measured by its ability to bind MICB antibody in ELISA.
Section Bar
 Preparation and Storage    Lyophilized MICB although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution MICB should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of MICB recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for MICB recombinant protein

   Description: MICB Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 326 amino acids and having a molecular mass of 37kDa. The sequence contains the extracellular domain of the mature human MICB (amino acid residues Ala23 Tyr312). The MICB is purified by proprietary chromatographic techniques.

Introduction: MICB (MHC class I chain-related gene B) is a transmembrane glycoprotein that functions as a ligand for human NKG2D type II receptor. A closely related protein, MICA, shares 85% amino acid identity with MICB. These 2 proteins are distantly related to the MHC class I proteins. MICA and MICB (MICA/B) possess three extracellular immunoglobulin-like domains, but have no capacity to bind peptide or interact with ?2-microglobulin. The genes encoding MICA/B are found within the major histocompatibility complex on human chromosome 6. The MICB locus is polymorphic with more than 15 recognized human alleles. MICA/B are minimally expressed on normal cells, but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B are ligands for NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells, and CD8+ T cells. Recognition of MICA/B by NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. MICA/B recognition is involved in tumor surveillance, viral infections, and autoimmune diseases. The release of soluble forms of MICA/B from tumors down-regulates NKG2D surface expression on effector cells resulting in the impairment of anti-tumor immune response.
 Product Categories/Family for MICB recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; MHC class I chain-related gene
NCBI/Uniprot data below describe general gene information for MICB. It may not necessarily be applicable to this product.
 NCBI GI #    574584674
 NCBI GeneID    4277
 NCBI Accession #    NP_001276089.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001289160.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q29980 [Other Products]
 UniProt Secondary Accession #    O14499; O14500; O19798; O19799; O19800; O19801; O19802; A2AC57; A6NP85; B0UZ10; B2RAK2 [Other Products]
 UniProt Related Accession #    Q29980 [Other Products]
 Molecular Weight    4,287 Da
Table BarTOPTable Bar
 NCBI Official Full Name    MHC class I polypeptide-related sequence B isoform 2
 NCBI Official Synonym Full Names    MHC class I polypeptide-related sequence B
 NCBI Official Symbol    MICB [Similar Products]
 NCBI Official Synonym Symbols   
PERB11.2
[Similar Products]
 NCBI Protein Information    MHC class I polypeptide-related sequence B; MHC class I chain-related protein B; MHC class I mic-B antigen; MHC class I-like molecule PERB11.2-IMX; MICB; stress inducible class I homolog
 UniProt Protein Name    MHC class I polypeptide-related sequence B
 Protein Family    MHC class I polypeptide-related sequence
 UniProt Gene Name    MICB [Similar Products]
 UniProt Synonym Gene Names    MIC-B [Similar Products]
 UniProt Entry Name    MICB_HUMAN
Section Bar
 NCBI Summary for MICB    This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Section Bar
 UniProt Comments for MICB    MICB: Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis. Genetic variations in MICA are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. The MICB*004 allele is associated with rheumatoid arthritis. Genetic variation in MICB is associated with cytomegalovirus and herpes simplex virus I seropositivity and this may be associated with schizophrenia risk. Belongs to the MHC class I family. MIC subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cell surface; integral to membrane; plasma membrane

Molecular Function: beta-2-microglobulin binding; antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; regulation of immune response; response to retinoic acid; viral reproduction; response to heat; natural killer cell mediated cytotoxicity; cytolysis; immune response-activating cell surface receptor signaling pathway; negative regulation of defense response to virus by host; response to oxidative stress; gamma-delta T cell activation; T cell mediated cytotoxicity
Table BarTOPTable Bar
 Research Articles on MICB    1. MICb expression in macrophage foam cells infiltrating atherosclerotic plaques
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with MICB recombinant proteinDiseases associated with MICB recombinant protein
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >47 publications with MICB and Carcinoma
 Adenocarcinoma Antibodies  >25 publications with MICB and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >20 publications with MICB and Cardiovascular Diseases
 Necrosis Antibodies  >20 publications with MICB and Necrosis
 Liver Diseases Antibodies  >18 publications with MICB and Liver Diseases
 Liver Neoplasms Antibodies  >12 publications with MICB and Liver Neoplasms
 Inflammation Antibodies  >11 publications with MICB and Inflammation
 Neoplasm Metastasis Antibodies  >11 publications with MICB and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >10 publications with MICB and Carcinoma, Hepatocellular
 Neoplasms, Experimental Antibodies  >10 publications with MICB and Neoplasms, Experimental
Organs/Tissues associated with MICB recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >212 publications with MICB and Blood
 Lung Antibodies  >19 publications with MICB and Lung
 Liver Antibodies  >18 publications with MICB and Liver
 Intestine Antibodies  >11 publications with MICB and Intestine
 Kidney Antibodies  >11 publications with MICB and Kidney
 Lymph Antibodies  >7 publications with MICB and Lymph
 Bone Marrow Antibodies  >7 publications with MICB and Bone Marrow
 Brain Antibodies  >6 publications with MICB and Brain
 Thymus Antibodies  >4 publications with MICB and Thymus
 Vascular Antibodies  >3 publications with MICB and Vascular
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions