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MIP-1 beta (CCL4) recombinant protein

Scan QR to view Datasheet Catalog #    MBS692135 MIP-1 beta (CCL4) recombinant protein
Unit / Price
0.002 mg  /  $200 +1 FREE 8GB USB
0.01 mg  /  $325 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MIP-1 beta (CCL4) (MIP-1 beta (CCL4)), Recombinant Protein

 Also Known As   

Human MIP-1 beta (CCL4)

 Product Synonym Names    Recombinant Human MIP-1beta
 Product Gene Name   

MIP-1 beta (CCL4) recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    APMGSDPPTA CCFSYTARKL PHNFVVDYYE TSSLCSQPAV VFQTKR GKQV CADPSESWVQ EYVYDLELN
 Chromosome Location    Chromosome: 17; NC_000017.11 (36211066..36212873). Location: 17q12
 OMIM    182284
 3D Structure    ModBase 3D Structure for P13236
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    > 99 % (SDS-PAGE, HPLC)
 Form/Format    Lyophilized
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 Endotoxin Level    < 0.1 ng per ug of MIP-1beta
 Biological Activity    Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.
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 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of MIP-1 beta (CCL4) recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MIP-1 beta (CCL4) recombinant protein

   Both MIP-1alpha and MIP-1beta are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1alpha and MIP-1beta exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1alpha selectively attracting CD8+ lymphocytes and MIP-1beta selectively attracting CD4+ lymphocytes. Additionally, MIP-1alpha and MIP-1beta have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1alpha and MIP-1beta are active on human and murine hematopoietic cells. Recombinant human MIP-1betais a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.
 Product Categories/Family for MIP-1 beta (CCL4) recombinant protein    Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for MIP-1 beta (CCL4). It may not necessarily be applicable to this product.
 NCBI GI #    47824887
 NCBI GeneID    9560
 NCBI Accession #    NP_001001435.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001001435.2 [Other Products]
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 UniProt Primary Accession #    P13236 [Other Products]
 UniProt Secondary Accession #    P22617; Q13704; Q3SXL8; Q6FGI8 [Other Products]
 UniProt Related Accession #    Q8NHW4 [Other Products]
 Molecular Weight    7.6 kDa
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 NCBI Official Full Name    C-C motif chemokine 4-like
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 4-like 1
 NCBI Official Symbol    CCL4L1 [Similar Products]
 NCBI Official Synonym Symbols   
LAG1; CCL4L; LAG-1; SCYA4L; AT744.2
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 4-like; MIP-1-beta; macrophage inflammatory protein-1b2; lymphocyte activation gene 1 protein; macrophage inflammatory protein 1-beta; monocyte adherence-induced protein 5-alpha
 UniProt Protein Name    C-C motif chemokine 4
 UniProt Synonym Protein Names   
G-26 T-lymphocyte-secreted protein; HC21; Lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); Macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; Protein H400; SIS-gamma; Small-inducible cytokine A4; T-cell activation protein 2
 UniProt Gene Name    CCL4 [Similar Products]
 UniProt Synonym Gene Names    LAG1; MIP1B; SCYA4; LAG-1; MIP-1-beta; ACT-2 [Similar Products]
 UniProt Entry Name    CCL4_HUMAN
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 NCBI Summary for MIP-1 beta (CCL4)    This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. This protein is similar to CCL4 which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals; most individuals have 1-5 copies in the diploid genome, although rare individuals do not contain this gene at all. The human genome reference assembly contains two copies of this gene. This record represents the more centromeric gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MIP-1 beta (CCL4)    Function: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B Ref.13 Ref.14 Ref.15

Subunit structure: Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69). Ref.15

Subcellular location: Secreted.

Induction: By mitogens.

Post-translational modification: N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.

Sequence similarities: Belongs to the intercrine beta (chemokine CC) family.

Caution: Was originally (Ref.12) thought to be a ligand for CCR8.
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 Research Articles on MIP-1 beta (CCL4)    1. CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MIP-1 beta (CCL4) recombinant proteinPathways associated with MIP-1 beta (CCL4) recombinant protein
 Reference Product  PubMed Publications
 CCL3 recombinant protein  >5 publications with MIP-1 beta (CCL4) and CCL3
 CCR5 recombinant protein  >3 publications with MIP-1 beta (CCL4) and CCR5
 CCR3 recombinant protein  >1 publications with MIP-1 beta (CCL4) and CCR3
 CCR1 recombinant protein  >1 publications with MIP-1 beta (CCL4) and CCR1
 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
Diseases associated with MIP-1 beta (CCL4) recombinant proteinOrgans/Tissues associated with MIP-1 beta (CCL4) recombinant protein
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >4 publications with MIP-1 beta (CCL4) and Immune System Diseases
 Disease Susceptibility Antibodies  >3 publications with MIP-1 beta (CCL4) and Disease Susceptibility
 Diabetes Mellitus Antibodies  >1 publications with MIP-1 beta (CCL4) and Diabetes Mellitus
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with MIP-1 beta (CCL4) and Blood
 Kidney Antibodies  >1 publications with MIP-1 beta (CCL4) and Kidney
 Lung Antibodies  >1 publications with MIP-1 beta (CCL4) and Lung
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