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MOBKL1B recombinant protein

Scan QR to view Datasheet Catalog #    MBS203969
SDS-PAGE
Unit / Price
0.1 mg  /  $310 +1 FREE 8GB USB
0.5 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MOBKL1B, Recombinant Protein

★Popular Item★
 Also Known As   

MOBKL1B, 1-216aa, Human, His tag, E Coli

 Product Synonym Names    Mps one binder kinase activator-like 1B; C2orf6; FLJ10788; FLJ11595; MATS1; MOB1; Mob4B; MOBK1B
 Product Gene Name   

MOBKL1B recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MSFLFSSRSS KTFKPKKNIP EGSHQYELLK HAEATLGSGN LRQAVMLPEG EDLNEWIAVN TVDFFNQINM LYGTITEFCT EASCPVMSAG PRYEYHWADG TNIKKPIKCS APKYIDYLMT WVQDQLDDET LFPSKIGVPF PKNFMSVAKT ILKRLFRVYA HIYHQHFDSV MQLQEEAHLN TSFKHFIFFV QEFNLIDRRE LAPLQELIEK LGSKDR
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 Purity/Purification    > 95% by SDS - PAGE
 Form/Format    Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 5mM DTT, 30% glycerol
 Concentration    0.5 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag    His-tag
 Expression System    E Coli
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks). For long term storage, aliquot and store at -20 degree C or -70 degree C. Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of MOBKL1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MOBKL1B recombinant protein

   MOBKL1B, also known as MOB1B, belongs to the MOB1/phocein family. It stimulates the kinase activity of STK38 and STK38L. MOBKL1B binds to and regulate downstream targets such as the NDR-family protein kinases and LATS1 kinase. Therefore, MOBKL1B participates in cell cycle checkpoint control and tumor inhibition. Recombinant human MOBKL1B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
 Product Categories/Family for MOBKL1B recombinant protein    Cancer
 Applications Tested/Suitable for MOBKL1B recombinant protein   

SDS-PAGE

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 SDS-PAGE of MOBKL1B recombinant protein    MOBKL1B recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for MOBKL1B. It may not necessarily be applicable to this product.
 NCBI GI #    148747437
 NCBI GeneID    55233
 NCBI Accession #    NP_060691 [Other Products]
 NCBI GenBank Nucleotide #    NM_018221.3 [Other Products]
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 UniProt Secondary Accession #    Q53S34; Q9H3T5; Q9HAI0; Q9NVE2 [Other Products]
 UniProt Related Accession #    Q9H8S9 [Other Products]
 Molecular Weight    27.2 kDa (236aa), confirmed by MALDI-TOF
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 NCBI Official Full Name    MOB kinase activator 1A
 NCBI Official Synonym Full Names    MOB kinase activator 1A
 NCBI Official Symbol    MOB1A [Similar Products]
 NCBI Official Synonym Symbols   
MOB1; MATS1; Mob4B; C2orf6; MOBK1B; MOBKL1B
[Similar Products]
 NCBI Protein Information    MOB kinase activator 1A; MOB1 Mps One Binder homolog A; MOB1, Mps One Binder kinase activator-like 1B; mob1 alpha; mob1 homolog 1B; mps one binder kinase activator-like 1B
 UniProt Protein Name    MOB kinase activator 1A
 UniProt Synonym Protein Names   
Mob1 alpha; Mob1A; Mob1 homolog 1B; Mps one binder kinase activator-like 1B
 UniProt Gene Name    MOB1A [Similar Products]
 UniProt Synonym Gene Names    C2orf6; MOB4B; MOBK1B; MOBKL1B; Mob1A [Similar Products]
 UniProt Entry Name    MOB1A_HUMAN
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 UniProt Comments for MOBKL1B    MOB1A: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver. Belongs to the MOB1/phocein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, regulatory subunit

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: cytosol

Molecular Function: protein binding; metal ion binding
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Product References and Citations for MOBKL1B recombinant protein

   Lai ZC., et al. (2005) Cell. 120(5):675-85.
Bichsel SJ., et al. (2004) J Biol Chem. 279(34):35228-35.
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 Research Articles on MOBKL1B    1. No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MOBKL1B recombinant proteinPathways associated with MOBKL1B recombinant protein
 Reference Product  PubMed Publications
 LATS1 recombinant protein  >12 publications with MOBKL1B and LATS1
 LATS2 recombinant protein  >7 publications with MOBKL1B and LATS2
 STK38 recombinant protein  >6 publications with MOBKL1B and STK38
 STK4 recombinant protein  >4 publications with MOBKL1B and STK4
 STK38L recombinant protein  >3 publications with MOBKL1B and STK38L
 Products by Pathway  Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hippo Pathway antibodies  Signaling By Hippo Pathway Diagram
Diseases associated with MOBKL1B recombinant proteinOrgans/Tissues associated with MOBKL1B recombinant protein
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >1 publications with MOBKL1B and Neoplasm Metastasis
 Gastrointestinal Neoplasms Antibodies  >1 publications with MOBKL1B and Gastrointestinal Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with MOBKL1B and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with MOBKL1B and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >2 publications with MOBKL1B and Liver
 Skin Antibodies  >2 publications with MOBKL1B and Skin
 Lung Antibodies  >2 publications with MOBKL1B and Lung
 Kidney Antibodies  >1 publications with MOBKL1B and Kidney
 Brain Antibodies  >1 publications with MOBKL1B and Brain
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