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MOCS2 recombinant protein

Scan QR to view Datasheet Catalog #    MBS204557
SDS-Page
Unit / Price
0.02 mg  /  $310 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

MOCS2, Recombinant Protein

★Popular Item★
 Also Known As   

MOCS2, 1-188aa, Human, His tag, E Coli

 Product Synonym Names    molybdenum cofactor synthesis 2; molybdenum cofactor synthesis 2; MCBPE; MOCO1; MOCS2A; MOCS2B; MPTS
 Product Gene Name   

MOCS2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMSSL EISSSCFSLE TKLPLSPPLV EDSAFEPSRK DMDEVEEKSK DVINFTAEKL SVDEVSQLVI SPLCGAISLF VGTTRNNFEG KKVISLEYEA YLPMAENEVR KICSDIRQKW PVKHIAVFHR LGLVPVSEAS IIIAVSSAHR AASLEAVSYA IDTLKAKVPI WKKEIYEESS TWKGNKECFW ASNS
 OMIM    AF091871 mRNA
 3D Structure    ModBase 3D Structure for O96007
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.15M NaCl, 50% glycerol, 1mM DTT
 Concentration    0.25 mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of MOCS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MOCS2 recombinant protein

   MOCS2 is a heterotetrameric synthase composed of two small (MOCS2A) and two large (MOCS2B) subunits. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. MOCS2 functions in the second step of the synthesis of molybdenum cofactor or molybdopterin (MPT). It catalyzes the formation of MPT from precursor Z by incorporating a dithiolene functional group. Recombinant human MOCS2 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for MOCS2 recombinant protein    Metabolism
 Applications Tested/Suitable for MOCS2 recombinant protein   

SDS-PAGE

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 SDS-Page of MOCS2 recombinant protein    MOCS2 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for MOCS2. It may not necessarily be applicable to this product.
 NCBI GI #    4758732
 NCBI GeneID    4338
 NCBI Accession #    NP_004522 [Other Products]
 NCBI GenBank Nucleotide #    NM_004531.4 [Other Products]
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 UniProt Primary Accession #    O96007 [Other Products]
 UniProt Secondary Accession #    Q6IAI3 [Other Products]
 UniProt Related Accession #    O96007; O96033 [Other Products]
 Molecular Weight    25 kDa (224aa) confirmed by MALDI-TOF
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 NCBI Official Full Name    molybdopterin synthase catalytic subunit large subunit MOCS2B
 NCBI Official Synonym Full Names    molybdenum cofactor synthesis 2
 NCBI Official Symbol    MOCS2 [Similar Products]
 NCBI Official Synonym Symbols   
MPTS; MCBPE; MOCO1; MOCODB
[Similar Products]
 NCBI Protein Information    molybdopterin synthase catalytic subunit; molybdopterin synthase sulfur carrier subunit
 UniProt Protein Name    Molybdopterin synthase catalytic subunit
 UniProt Synonym Protein Names   
MOCO1-B; Molybdenum cofactor synthesis protein 2 large subunit
 UniProt Gene Name    MOCS2 [Similar Products]
 UniProt Synonym Gene Names    MPT synthase large subunit [Similar Products]
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 NCBI Summary for MOCS2    Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MOCS2    Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.
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Product References and Citations for MOCS2 recombinant protein

   Leimkuhler S., et al. (2005) Hum Genet. 117: 565-570; Reiss J., et al. (1999) Hum Genet. 64: 706-711.
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 Research Articles on MOCS2    1. We reported here an infant with MoCD who presented with hypoxic ischaemic encephalopathy and identified a novel mutation, c.130C>T in cDNA of the MOCS2 gene from the infant.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MOCS2 recombinant proteinPathways associated with MOCS2 recombinant protein
 Reference Product  PubMed Publications
 MOCS1 recombinant protein  >18 publications with MOCS2 and MOCS1
 MOCS3 recombinant protein  >7 publications with MOCS2 and MOCS3
 SUOX recombinant protein  >3 publications with MOCS2 and SUOX
 XDH recombinant protein  >1 publications with MOCS2 and XDH
 AOX1 recombinant protein  >1 publications with MOCS2 and AOX1
 GPHN recombinant protein  >1 publications with MOCS2 and GPHN
 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Molybdenum Cofactor Biosynthesis Pathway antibodies  Molybdenum Cofactor Biosynthesis Pathway Diagram
 Sulfur Relay System Pathway antibodies  Sulfur Relay System Pathway Diagram
 Sulfur Relay System Pathway antibodies  Sulfur Relay System Pathway Diagram
 Molybdenum Cofactor Biosynthesis Pathway antibodies  Molybdenum Cofactor Biosynthesis Pathway Diagram
Diseases associated with MOCS2 recombinant proteinOrgans/Tissues associated with MOCS2 recombinant protein
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with MOCS2 and Kidney Diseases
 Disease Models, Animal Antibodies  >2 publications with MOCS2 and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with MOCS2 and Lung Neoplasms
 Hypertension Antibodies  >1 publications with MOCS2 and Hypertension
 Fibrosis Antibodies  >1 publications with MOCS2 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >10 publications with MOCS2 and Brain
 Blood Antibodies  >4 publications with MOCS2 and Blood
 Kidney Antibodies  >3 publications with MOCS2 and Kidney
 Skin Antibodies  >1 publications with MOCS2 and Skin
 Liver Antibodies  >1 publications with MOCS2 and Liver
 Placenta Antibodies  >1 publications with MOCS2 and Placenta
 Lung Antibodies  >1 publications with MOCS2 and Lung
 Bladder Antibodies  >1 publications with MOCS2 and Bladder
 Embryonic Tissue Antibodies  >1 publications with MOCS2 and Embryonic Tissue
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