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M CSF recombinant protein :: Macrophage Colony Stimulating Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143729 M CSF recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage Colony Stimulating Factor (M CSF), Recombinant Protein

 Also Known As   

Recombinant Human Macrophage Colony Stimulating Factor, His Tag

 Product Synonym Names    M CSF Human, His; Macrophage Colony Stimulating Factor Human Recombinant, His Tag; CSF-1; Lanimostim; MCSF; MGC31930; M-CSF; M CSF His
 Product Gene Name   

M CSF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ DVVTKPDCN.
 OMIM    120420
 3D Structure    ModBase 3D Structure for P09603
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 Host    E Coli
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The MCSF protein solution contains 20mM Tris-HCl, pH-8, 2mM DTT & 10% Glycerol.
Sterile filtered colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of M CSF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for M CSF recombinant protein

   Description: Macrophage Colony Stimulating Factor Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 179 amino acids (33-190 a.a.) and having a total molecular mass of 20.7 kDa.MCSF is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

Introduction: Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.
 Product Categories/Family for M CSF recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Colony Stimulating Factor
NCBI/Uniprot data below describe general gene information for M CSF. It may not necessarily be applicable to this product.
 NCBI GI #    27262661
 NCBI GeneID    1435
 NCBI Accession #    NP_000748.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_000757.5 [Other Products]
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 UniProt Primary Accession #    P09603 [Other Products]
 UniProt Secondary Accession #    Q13130; Q14086; Q14806; Q5VVF3; Q5VVF4; Q9UQR8; A8K6J5 [Other Products]
 UniProt Related Accession #    P09603 [Other Products]
 Molecular Weight    29,215 Da
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 isoform a
 NCBI Official Synonym Full Names    colony stimulating factor 1 (macrophage)
 NCBI Official Symbol    CSF1 [Similar Products]
 NCBI Official Synonym Symbols   
MCSF; CSF-1
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1; lanimostim
 UniProt Protein Name    Macrophage colony-stimulating factor 1
 UniProt Synonym Protein Names   
LanimostimProcessed macrophage colony-stimulating factor 1
 UniProt Gene Name    CSF1 [Similar Products]
 UniProt Synonym Gene Names    CSF-1; M-CSF; MCSF [Similar Products]
 UniProt Entry Name    CSF1_HUMAN
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 NCBI Summary for M CSF    The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
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 UniProt Comments for M CSF    M-CSF: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance. Aberrant expression of CSF1 or CSF1R can promote cancer cell proliferation, invasion and formation of metastases. Overexpression of CSF1 or CSF1R is observed in a significant percentage of breast, ovarian, prostate, and endometrial cancers. Aberrant expression of CSF1 or CSF1R may play a role in inflammatory diseases, such as rheumatoid arthritis, glomerulonephritis, atherosclerosis, and allograft rejection. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cytokine

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: extracellular space; membrane; perinuclear region of cytoplasm; integral to membrane; plasma membrane; receptor complex

Molecular Function: protein homodimerization activity; growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of monocyte differentiation; macrophage differentiation; positive regulation of osteoclast differentiation; positive regulation of cellular protein metabolic process; positive regulation of multicellular organism growth; osteoclast differentiation; odontogenesis; monocyte activation; positive regulation of cell proliferation; hemopoiesis; cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of macrophage differentiation; inflammatory response; ossification; positive regulation of odontogenesis of dentine-containing teeth; reproductive developmental process; cell proliferation; positive regulation of mononuclear cell proliferation; homeostasis of number of cells within a tissue; positive regulation of protein kinase activity; innate immune response; positive regulation of Ras protein signal transduction; regulation of ossification; positive regulation of cell migration
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 Research Articles on M CSF    1. potent profibrotic factor in hepatitis C virus liver fibrosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with M CSF recombinant proteinPathways associated with M CSF recombinant protein
 Reference Product  PubMed Publications
 CSF1R recombinant protein  >93 publications with M CSF and CSF1R
 JUN recombinant protein  >22 publications with M CSF and JUN
 GAPDH recombinant protein  >3 publications with M CSF and GAPDH
 MYC recombinant protein  >3 publications with M CSF and MYC
 ITGB3 recombinant protein  >1 publications with M CSF and ITGB3
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Integrins In Angiogenesis Pathway antibodies  Integrins In Angiogenesis Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with M CSF recombinant proteinOrgans/Tissues associated with M CSF recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >38 publications with M CSF and Inflammation
 Carcinoma Antibodies  >26 publications with M CSF and Carcinoma
 Necrosis Antibodies  >21 publications with M CSF and Necrosis
 Breast Neoplasms Antibodies  >21 publications with M CSF and Breast Neoplasms
 Adenocarcinoma Antibodies  >14 publications with M CSF and Adenocarcinoma
 Lung Neoplasms Antibodies  >14 publications with M CSF and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >10 publications with M CSF and Neoplasms, Experimental
 Lung Diseases Antibodies  >9 publications with M CSF and Lung Diseases
 Liver Diseases Antibodies  >7 publications with M CSF and Liver Diseases
 Osteitis Deformans Antibodies  >6 publications with M CSF and Osteitis Deformans
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >70 publications with M CSF and Blood
 Bone Antibodies  >61 publications with M CSF and Bone
 Lung Antibodies  >28 publications with M CSF and Lung
 Liver Antibodies  >18 publications with M CSF and Liver
 Brain Antibodies  >16 publications with M CSF and Brain
 Connective Tissue Antibodies  >13 publications with M CSF and Connective Tissue
 Lymph Node Antibodies  >12 publications with M CSF and Lymph Node
 Intestine Antibodies  >10 publications with M CSF and Intestine
 Kidney Antibodies  >10 publications with M CSF and Kidney
 Spleen Antibodies  >9 publications with M CSF and Spleen
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