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MIP 5 recombinant protein :: Macrophage Inflammatory protein-5 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143173 MIP 5 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage Inflammatory protein-5 (MIP 5), Recombinant Protein

 Also Known As   

Recombinant Human Macrophage Inflammatory protein-5 (CCL15)

 Product Synonym Names    MIP 5 Human; Macrophage Inflammatory Protein-5 Human Recombinant (CCL15); Small inducible cytokine A15 precursor; CCL15; Macrophage inflammatory protein 5; MIP-5; MIP5; Chemokine CC-2; HCC-2; NCC-3; MIP- 1 delta; Leukotactin-1; LKN-1; Mrp-2b; C-C motif chemokine 15
 Product Gene Name   

MIP 5 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    QFINDAETEL MMSKLPLENP VVLNSFHFAA DCCTSYISQS IPCSLMKSYF ETSSECSKP GVIFLTKKGR QVCAKPSGPG VQDCMKKLKP YSI.
 OMIM    601393
 3D Structure    ModBase 3D Structure for Q16663
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 Host    E Coli
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 Purity/Purification    Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    MIP5 was lyophilized from a concentrated (1mg/ml) solution containing 20mM PBS pH-7.4 and 100mM NaCl.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized MIP5 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Determined by its ability to chemoattract human T-lymphocytes using a concentration range of 1-10 ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.
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 Preparation and Storage    Lyophilized MIP-5 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL15 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of MIP 5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MIP 5 recombinant protein

   Description: Macrophage Inflammatory Protein-5 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 92 amino acids and having a molecular mass of 10.1 kDa. The MIP5 is purified by proprietary chromatographic techniques.

Introduction: CCL15, a new human CC chemokine, was isolated from a human fetal spleen cDNA library. CCL15 cDNA encodes a predicted 113 amino acid (aa) protein containing a putative signal peptide of 21 amino acids that is cleaved to generate a 92 aa residue mature protein. Within the CC family members, human CCL15 shares 45%, 44%, 35%, and 30% aa homology with mouse C10, human MPIF-1, human HCC-1, and mouse MIP-1, respectively. The gene for MIP-5 is found on chromosome 17 where the genes for most of the human CC chemokines are located. Human CCL15 is expressed in T and B lymphocytes, NK cells, monocytes and monocyte-derived dendritic cells. Human MIP-5 is chemotactic for T cells and monocytes and has been shown to induce calcium flux in human CCR-1-transfected cells.
 Product Categories/Family for MIP 5 recombinant protein    CHEMOKINES; Chemokines; MIP
NCBI/Uniprot data below describe general gene information for MIP 5. It may not necessarily be applicable to this product.
 NCBI GI #    597709818
 NCBI GeneID    6359
 NCBI Accession #    NP_116741.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_032965.5 [Other Products]
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 UniProt Primary Accession #    Q16663 [Other Products]
 UniProt Secondary Accession #    Q9UM74; B2RU34; E1P651 [Other Products]
 UniProt Related Accession #    Q16663 [Other Products]
 Molecular Weight    12,248 Da
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 NCBI Official Full Name    C-C motif chemokine 15 preproprotein
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 15
 NCBI Official Symbol    CCL15 [Similar Products]
 NCBI Official Synonym Symbols   
LKN1; NCC3; SY15; HCC-2; LKN-1; MIP-5; NCC-3; SCYL3; MIP-1D; MRP-2B; SCYA15; HMRP-2B; MIP-1 delta
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 15; chemokine CC-2; leukotactin 1; macrophage inflammatory protein 5; new CC chemokine 3; small inducible cytokine subfamily A (Cys-Cys), member 15; small-inducible cytokine A15
 UniProt Protein Name    C-C motif chemokine 15
 UniProt Synonym Protein Names   
Chemokine CC-2; HCC-2; Leukotactin-1; LKN-1; MIP-1 delta; Macrophage inflammatory protein 5; MIP-5; Mrp-2b; NCC-3; Small-inducible cytokine A15Cleaved into the following 3 chains:CCL15(22-92); CCL15(25-92); CCL15(29-92)
 UniProt Gene Name    CCL15 [Similar Products]
 UniProt Synonym Gene Names    MIP5; NCC3; SCYA15; HCC-2; LKN-1; MIP-5 [Similar Products]
 UniProt Entry Name    CCL15_HUMAN
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 NCBI Summary for MIP 5    This gene is located in a cluster of similar genes in the same region of chromosome 17. These genes encode CC cytokines, which are secreted proteins characterized by two adjacent cysteines. The product of this gene is chemotactic for T cells and monocytes, and acts through C-C chemokine receptor type 1 (CCR1). The proprotein is further processed into numerous smaller functional peptides. Naturally-occurring readthrough transcripts occur from this gene into the downstream gene, CCL14 (chemokine (C-C motif) ligand 14). [provided by RefSeq, Jan 2013]
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 UniProt Comments for MIP 5    CCL15: Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular space

Molecular Function: heparin binding; chemokine activity; receptor binding; chemoattractant activity

Biological Process: cellular calcium ion homeostasis; cell-cell signaling; positive chemotaxis; immune response; signal transduction; chemotaxis
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 Research Articles on MIP 5    1. we investigated a role of CCL15 in upregulating ICAM-1 in endothelial cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MIP 5 recombinant proteinPathways associated with MIP 5 recombinant protein
 Reference Product  PubMed Publications
 CCR1 recombinant protein  >28 publications with MIP 5 and CCR1
 CCR3 recombinant protein  >11 publications with MIP 5 and CCR3
 CCR2 recombinant protein  >5 publications with MIP 5 and CCR2
 CCR5 recombinant protein  >4 publications with MIP 5 and CCR5
 CCR6 recombinant protein  >2 publications with MIP 5 and CCR6
 CCR8 recombinant protein  >1 publications with MIP 5 and CCR8
 CCR7 recombinant protein  >1 publications with MIP 5 and CCR7
 Products by Pathway  Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
Diseases associated with MIP 5 recombinant proteinOrgans/Tissues associated with MIP 5 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >22 publications with MIP 5 and Inflammation
 Necrosis Antibodies  >7 publications with MIP 5 and Necrosis
 Carcinoma Antibodies  >6 publications with MIP 5 and Carcinoma
 Liver Neoplasms Antibodies  >5 publications with MIP 5 and Liver Neoplasms
 Liver Diseases Antibodies  >5 publications with MIP 5 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with MIP 5 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >3 publications with MIP 5 and Kidney Diseases
 Adenocarcinoma Antibodies  >3 publications with MIP 5 and Adenocarcinoma
 Atherosclerosis Antibodies  >2 publications with MIP 5 and Atherosclerosis
 Lung Neoplasms Antibodies  >2 publications with MIP 5 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >8 publications with MIP 5 and Liver
 Lung Antibodies  >6 publications with MIP 5 and Lung
 Kidney Antibodies  >4 publications with MIP 5 and Kidney
 Intestine Antibodies  >3 publications with MIP 5 and Intestine
 Brain Antibodies  >2 publications with MIP 5 and Brain
 Ascites Antibodies  >1 publications with MIP 5 and Ascites
 Prostate Antibodies  >1 publications with MIP 5 and Prostate
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