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MIF recombinant protein :: Macrophage Migration Inhibitor Factor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143329 MIF recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage Migration Inhibitor Factor (MIF), Recombinant Protein

 Also Known As   

Recombinant Human Macrophage Migration Inhibitor Factor

 Product Synonym Names    MIF Human; Macrophage Migration Inhibitory Factor Human Recombinant; Phenylpyruvate tautomerase; Glycosylation-inhibiting factor; GIF; MMIF; MIF
 Product Gene Name   

MIF recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV HVVPDQLMAF GGSSEPCALC SLHSIGKIGG AQNRSYSKLL CGLLAERLRI   SPDRVYINYY DMNAANVGWN NSTFA.
 OMIM    153620
 3D Structure    ModBase 3D Structure for P14174
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by SDS-PAGE.
 Form/Format    1mg/ml solution containing 50mM Tris-HCl pH-8, 0.5mM DTT & 10% glycerol.
Sterile Filtered clear solution.
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 Other Notes    Small volumes of MIF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MIF recombinant protein

   Description: MIF human Recombinant was cloned into an E Coli expression vector and was purified to apparent homogeneity by using conventional column chromatography techniques.Macrophage Inducing Factor Human Recombinant is a single, non-glycosylated, polypeptide chain containing 115 amino acids and having a molecular mass of 12 kDa.

Introduction: The cytokine Macrophage migration inhibitory factor (MIF) has been identified to be secreted by the pituitary gland and the monocyte/macrophage and to play an important role in endotoxic shock. MIF has the unique property of being released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secretion of MIF is tightly regulated and decreases at high, anti-inflammatory steroid concentration.
 Product Categories/Family for MIF recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Macrophage Migration Inhibitory Factor
NCBI/Uniprot data below describe general gene information for MIF. It may not necessarily be applicable to this product.
 NCBI GI #    4505185
 NCBI GeneID    4282
 NCBI Accession #    NP_002406.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002415.1 [Other Products]
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 UniProt Primary Accession #    P14174 [Other Products]
 UniProt Secondary Accession #    Q2V4Y5; Q6FHV0; A5Z1R8; B2R4S3 [Other Products]
 UniProt Related Accession #    P14174 [Other Products]
 Molecular Weight    12,476 Da
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 NCBI Official Full Name    macrophage migration inhibitory factor
 NCBI Official Synonym Full Names    macrophage migration inhibitory factor (glycosylation-inhibiting factor)
 NCBI Official Symbol    MIF [Similar Products]
 NCBI Official Synonym Symbols   
GIF; GLIF; MMIF
[Similar Products]
 NCBI Protein Information    macrophage migration inhibitory factor; L-dopachrome isomerase; L-dopachrome tautomerase; phenylpyruvate tautomerase
 UniProt Protein Name    Macrophage migration inhibitory factor
 UniProt Synonym Protein Names   
Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase (EC:5.3.3.12); Phenylpyruvate tautomerase
 Protein Family    Macrophage migration inhibitory factor
 UniProt Gene Name    MIF [Similar Products]
 UniProt Synonym Gene Names    GLIF; MMIF; MIF; GIF [Similar Products]
 UniProt Entry Name    MIF_HUMAN
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 NCBI Summary for MIF    This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MIF    MIF: a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. Also acts as a phenylpyruvate tautomerase.

Protein type: Cell development/differentiation; Amino Acid Metabolism - phenylalanine; Apoptosis; EC 5.3.2.1; EC 5.3.3.12; Amino Acid Metabolism - tyrosine; Cytokine; Isomerase

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: nucleoplasm; extracellular space; cell surface; cytoplasm; extracellular region; vesicle

Molecular Function: phenylpyruvate tautomerase activity; protein binding; hematopoietin/interferon-class (D200-domain) cytokine receptor binding; cytokine activity; dopachrome isomerase activity; chemoattractant activity; receptor binding

Biological Process: DNA damage response, signal transduction by p53 class mediator; regulation of macrophage activation; positive regulation of lipopolysaccharide-mediated signaling pathway; carboxylic acid metabolic process; cell aging; negative regulation of cellular protein metabolic process; prostaglandin biosynthetic process; positive regulation of peptidyl-serine phosphorylation; negative regulation of DNA damage response, signal transduction by p53 class mediator; positive regulation of MAP kinase activity; cell proliferation; positive regulation of fibroblast proliferation; negative regulation of myeloid cell apoptosis; positive regulation of peptidyl-tyrosine phosphorylation; negative regulation of mature B cell apoptosis; cell surface receptor linked signal transduction; positive chemotaxis; positive regulation of B cell proliferation; innate immune response; inflammatory response; positive regulation of phosphorylation; positive regulation of cytokine secretion; negative regulation of apoptosis

Disease: Rheumatoid Arthritis, Systemic Juvenile
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 Research Articles on MIF    1. Findings showed an increased extent of MIF expression in cancer cells and in stromal fibroblasts of Breast Cancer tumor, in contrast to a less uniform increase of CD74 expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MIF recombinant proteinPathways associated with MIF recombinant protein
 Reference Product  PubMed Publications
 CD74 recombinant protein  >150 publications with MIF and CD74
 COPS5 recombinant protein  >17 publications with MIF and COPS5
 MMP9 recombinant protein  >13 publications with MIF and MMP9
 TAT recombinant protein  >3 publications with MIF and TAT
 NME1 recombinant protein  >2 publications with MIF and NME1
 UBC recombinant protein  >2 publications with MIF and UBC
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
 Tyrosine Metabolism Pathway antibodies  Tyrosine Metabolism Pathway Diagram
Diseases associated with MIF recombinant proteinOrgans/Tissues associated with MIF recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >702 publications with MIF and Inflammation
 Necrosis Antibodies  >325 publications with MIF and Necrosis
 Disease Models, Animal Antibodies  >232 publications with MIF and Disease Models, Animal
 Lung Diseases Antibodies  >213 publications with MIF and Lung Diseases
 Carcinoma Antibodies  >163 publications with MIF and Carcinoma
 Sepsis Antibodies  >138 publications with MIF and Sepsis
 Arthritis, Rheumatoid Antibodies  >115 publications with MIF and Arthritis, Rheumatoid
 Heart Diseases Antibodies  >107 publications with MIF and Heart Diseases
 Pneumonia Antibodies  >83 publications with MIF and Pneumonia
 Kidney Diseases Antibodies  >81 publications with MIF and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1532 publications with MIF and Blood
 Brain Antibodies  >407 publications with MIF and Brain
 Vascular Antibodies  >246 publications with MIF and Vascular
 Skin Antibodies  >219 publications with MIF and Skin
 Lung Antibodies  >215 publications with MIF and Lung
 Muscle Antibodies  >205 publications with MIF and Muscle
 Liver Antibodies  >166 publications with MIF and Liver
 Spleen Antibodies  >164 publications with MIF and Spleen
 Heart Antibodies  >153 publications with MIF and Heart
 Lymph Antibodies  >131 publications with MIF and Lymph
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