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Csf1r recombinant protein :: Macrophage colony-stimulating factor 1 receptor (Csf1r) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS965935 Csf1r recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,280 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,280 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,500 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,500 +1 FREE 8GB USB
1 mg (E-Coli)  /  $2,105 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $2,105 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,570 +3 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,570 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrophage colony-stimulating factor 1 receptor (Csf1r), Recombinant Protein

 Also Known As   

Recombinant Mouse Macrophage colony-stimulating factor 1 receptor (Csf1r), partial

 Product Gene Name   

Csf1r recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    20-515
 Sequence    A PVIEPSGPEL VVEPGETVTL RCVSNGSVEW DGPISPYWTL DPESPGSTLT TRNATFKNTG TYRCTELEDP MAGSTTIHLY VKDPAHSWNL LAQEVTVVEG QEAVLPCLIT DPALKDSVSL MREGGRQVLR KTVYFFSPWR GFIIRKAKVL DSNTYVCKTM VNGRESTSTG IWLKVNRVHP EPPQIKLEPS KLVRIRGEAA QIVCSATNAE VGFNVILKRG DTKLEIPLNS DFQDNYYKKV RALSLNAVDF QDAGIYSCVA SNDVGTRTAT MNFQVVESAY LNLTSEQSLL QEVSVGDSLI LTVHADAYPS IQHYNWTYLG PFFEDQRKLE FITQRAIYRY TFKLFLNRVK ASEAGQYFLM AQNKAGWNNL TFELTLRYPP EVSVTWMPVN GSDVLFCDVS GYPQPSVTWM ECRGHTDRCD EAQALQVWND THPEVLSQKP FDKVIIQSQL PIGTLKHNMT YFCKTHNSVG NSSQYFRAVS LGQSKQLPDE SLFTP
 3D Structure    ModBase 3D Structure for P09581
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mouse
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Csf1r recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Csf1r recombinant protein

   This protein is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1
PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.
NCBI/Uniprot data below describe general gene information for Csf1r. It may not necessarily be applicable to this product.
 NCBI GI #    126723423
 NCBI GeneID    12978
 NCBI Accession #    NP_001032948.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001037859.2 [Other Products]
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 UniProt Primary Accession #    P09581 [Other Products]
 UniProt Secondary Accession #    Q3U3P1; Q9DBH9 [Other Products]
 UniProt Related Accession #    P09581 [Other Products]
 Molecular Weight    109,179 Da
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 NCBI Official Full Name    macrophage colony-stimulating factor 1 receptor
 NCBI Official Synonym Full Names    colony stimulating factor 1 receptor
 NCBI Official Symbol    Csf1r [Similar Products]
 NCBI Official Synonym Symbols   
Fms; Fim2; CD115; Csfmr; Fim-2; CSF-1R; M-CSFR; M-CSF-R; AI323359
[Similar Products]
 NCBI Protein Information    macrophage colony-stimulating factor 1 receptor
 UniProt Protein Name    Macrophage colony-stimulating factor 1 receptor
 UniProt Synonym Protein Names   
CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115
 Protein Family    Macrophage colony-stimulating factor 1 receptor
 UniProt Gene Name    Csf1r [Similar Products]
 UniProt Synonym Gene Names    Csfmr; Fms; CSF-1-R; CSF-1R; M-CSF-R [Similar Products]
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 UniProt Comments for Csf1r    Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.
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 Research Articles on Csf1r    1. Combining CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Csf1r recombinant proteinPathways associated with Csf1r recombinant protein
 Reference Product  PubMed Publications
 Grb2 recombinant protein  >50 publications with Csf1r and Grb2
 Ptpn11 recombinant protein  >48 publications with Csf1r and Ptpn11
 Cbl recombinant protein  >34 publications with Csf1r and Cbl
 Sos1 recombinant protein  >3 publications with Csf1r and Sos1
 Sfpi1 recombinant protein  >1 publications with Csf1r and Sfpi1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with Csf1r recombinant proteinOrgans/Tissues associated with Csf1r recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1287 publications with Csf1r and Necrosis
 Inflammation Antibodies  >735 publications with Csf1r and Inflammation
 Leukemia, Myeloid, Acute Antibodies  >380 publications with Csf1r and Leukemia, Myeloid, Acute
 Lung Diseases Antibodies  >303 publications with Csf1r and Lung Diseases
 Cardiovascular Diseases Antibodies  >172 publications with Csf1r and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >169 publications with Csf1r and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >165 publications with Csf1r and Breast Neoplasms
 Lymphoma Antibodies  >160 publications with Csf1r and Lymphoma
 Lung Neoplasms Antibodies  >79 publications with Csf1r and Lung Neoplasms
 Kidney Diseases Antibodies  >70 publications with Csf1r and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3195 publications with Csf1r and Blood
 Bone Antibodies  >1986 publications with Csf1r and Bone
 Bone Marrow Antibodies  >1449 publications with Csf1r and Bone Marrow
 Lung Antibodies  >424 publications with Csf1r and Lung
 Spleen Antibodies  >273 publications with Csf1r and Spleen
 Brain Antibodies  >254 publications with Csf1r and Brain
 Liver Antibodies  >206 publications with Csf1r and Liver
 Skin Antibodies  >197 publications with Csf1r and Skin
 Joint Antibodies  >163 publications with Csf1r and Joint
 Kidney Antibodies  >136 publications with Csf1r and Kidney
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