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Cd68 recombinant protein :: Macrosialin Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960585
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $955 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,195 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,200 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,735 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,815 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,310 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Macrosialin (Cd68), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse Macrosialin

 Product Synonym Names    CD68
 Product Gene Name   

Cd68 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    21-291aa; Extracellular Domain
 Sequence    DCPHKKAVTL LPSFTMTPTA TESTASPTTS HRPTTTSHGN VTVHTSSGPT TVTHNPATTT SHGNATISHA TVSPTTNGTA TSPRSSTVGP HPGPPPPSPS PRSKGALGNY TWANGSQPCV QLQAQIQIRI LYPIQGGRKA WGISVLNPNK TKVQGGCDGT HPHLSLSFPY GQLTFGFKQD LHQSPSTVYL DYMAVEYNVS FPQAAQWTFM AQNSSLRELQ APLGQSFCCG NASIVLSPAV HLDLLSLRLQ AAQLPDKGHF GPCFSCNRDQ S
 3D Structure    ModBase 3D Structure for P31996
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Cd68 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Cd68 recombinant protein

   Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
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 SDS-PAGE of Cd68 recombinant protein    Cd68 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Cd68. It may not necessarily be applicable to this product.
 NCBI GI #    597508192
 NCBI GeneID    12514
 NCBI Accession #    NP_001277987.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001291058.1 [Other Products]
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 UniProt Primary Accession #    P31996 [Other Products]
 UniProt Secondary Accession #    O54688; O70321; Q3S4A9; Q5F2A8; Q9DD15 [Other Products]
 UniProt Related Accession #    P31996 [Other Products]
 Molecular Weight    44.7kD
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 NCBI Official Full Name    macrosialin
 NCBI Official Synonym Full Names    CD68 antigen
 NCBI Official Symbol    Cd68 [Similar Products]
 NCBI Official Synonym Symbols   
Lamp4; gp110; Scard1
[Similar Products]
 NCBI Protein Information    macrosialin
 UniProt Protein Name    Macrosialin
 UniProt Synonym Protein Names   
CD_antigen: CD68
 Protein Family    Macrosialin
 UniProt Gene Name    Cd68 [Similar Products]
 UniProt Entry Name    CD68_MOUSE
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 UniProt Comments for Cd68    CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: endosome; integral to membrane; lysosome; membrane; plasma membrane
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Product References and Citations for Cd68 recombinant protein

   Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family.Holness C.L., da Silva R.P., Fawcett J., Gordon S., Simmons D.L.J. Biol. Chem. 268:9661-9666(1993) Structure, organization, and chromosomal mapping of the gene encoding macrosialin, a macrophage-restricted protein.Jiang Z., Shih D.M., Xia Y.R., Lusis A.J., de Beer F.C., de Villiers W.J.S., van der Westhuyzen D.R., de Beer M.C.Genomics 50:199-205(1998) Functional comparison of the murine macrosialin and human CD68 promoters in macrophage and nonmacrophage cell lines.Greaves D.R., Quinn C.M., Seldin M.F., Gordon S.Genomics 54:165-168(1998) The macrosialin promoter directs high levels of transcriptional activity in macrophages dependent on combinatorial interactions between PU.1 and c-Jun.Li A.C., Guidez F.R.B., Collier J.G., Glass C.K.J. Biol. Chem. 273:5389-5399(1998) Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11.Miyashita A., Shimizu N., Endo N., Hanyuu T., Ishii N., Ito K., Itoh Y., Shirai M., Nakajima T., Odani S., Kuwano R.Gene 237:53-60(1999) Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.PLoS Biol. 7:E1000112-E1000112(2009) Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice.Denny C.A., Kasperzyk J.L., Gorham K.N., Bronson R.T., Seyfried T.N.J. Neurosci. Res. 83:1028-1038(2006)
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 Research Articles on Cd68    1. CD68, a putative receptor for sporozoite invasion of Kupffer cells that acts as a gateway for malaria infection of the liver.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Cd68 recombinant proteinPathways associated with Cd68 recombinant protein
 Reference Product  PubMed Publications
 Itgam recombinant protein  >183 publications with Cd68 and Itgam
 Itgax recombinant protein  >145 publications with Cd68 and Itgax
 Csf1r recombinant protein  >84 publications with Cd68 and Csf1r
 Aif1 recombinant protein  >52 publications with Cd68 and Aif1
 Lgals3 recombinant protein  >28 publications with Cd68 and Lgals3
 Ptprc recombinant protein  >26 publications with Cd68 and Ptprc
 Emr1 recombinant protein  >14 publications with Cd68 and Emr1
 Cxcl16 recombinant protein  >5 publications with Cd68 and Cxcl16
 Tyrobp recombinant protein  >4 publications with Cd68 and Tyrobp
 Slc11a1 recombinant protein  >1 publications with Cd68 and Slc11a1
 Products by Pathway  Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Lysosome Pathway antibodies  Lysosome Pathway Diagram
 Macrophage Markers Pathway antibodies  Macrophage Markers Pathway Diagram
Diseases associated with Cd68 recombinant proteinOrgans/Tissues associated with Cd68 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1906 publications with Cd68 and Inflammation
 Cardiovascular Diseases Antibodies  >1022 publications with Cd68 and Cardiovascular Diseases
 Necrosis Antibodies  >976 publications with Cd68 and Necrosis
 Disease Models, Animal Antibodies  >552 publications with Cd68 and Disease Models, Animal
 Fibrosis Antibodies  >544 publications with Cd68 and Fibrosis
 Lung Diseases Antibodies  >480 publications with Cd68 and Lung Diseases
 Kidney Diseases Antibodies  >415 publications with Cd68 and Kidney Diseases
 Atherosclerosis Antibodies  >398 publications with Cd68 and Atherosclerosis
 Adenocarcinoma Antibodies  >344 publications with Cd68 and Adenocarcinoma
 Liver Diseases Antibodies  >338 publications with Cd68 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1159 publications with Cd68 and Muscle
 Skin Antibodies  >983 publications with Cd68 and Skin
 Bone Antibodies  >943 publications with Cd68 and Bone
 Liver Antibodies  >600 publications with Cd68 and Liver
 Lymph Node Antibodies  >583 publications with Cd68 and Lymph Node
 Lung Antibodies  >550 publications with Cd68 and Lung
 Kidney Antibodies  >548 publications with Cd68 and Kidney
 Connective Tissue Antibodies  >478 publications with Cd68 and Connective Tissue
 Heart Antibodies  >425 publications with Cd68 and Heart
 Joint Antibodies  >420 publications with Cd68 and Joint
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