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HLA-DRB1 recombinant protein :: Major Histocompatibility Complex Class II DR Beta 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS146068 HLA-DRB1 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Major Histocompatibility Complex Class II DR Beta 1 (HLA-DRB1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Major Histocompatibility Complex Class II DR Beta 1

 Product Synonym Names    HLA-DRB1 Human; Major Histocompatibility Complex Class II DR Beta 1 Human Recombinant; DRB1; HLA DRB1; HLA-DR1B; HLA-DRB1; MHC class II antigen DRB1 16; DR-16; DR16; Human Leucocyte AntigenDRB1; MHC Class IIHLA-DR-Beta Cell Surface Glycoprotein; MHC Class IIHLA-DRw10-Beta
 Product Gene Name   

HLA-DRB1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGDTRP RFLW QPKRECHFFN GTERVRFLDR YFYNQEESVR FDSDVGEFRA VTELGRPDAE YWNSQKDILE QARAAVDTYC RHNYGVVESF TVQRRVQPKV TVYPSKTQPL QHHNLLVCSV SGFYPGSIEV RWFLNGQEEK AGMVSTGLIQ NGDWTFQTLV MLETVPRSGE VYTCQVEHPS VTSPLTVEWR ARSESAQSK< u>
 OMIM    142857
 3D Structure    ModBase 3D Structure for Q29974
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 Host    E Coli
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 Purity/Purification    Greater than 85% as determined by SDS-PAGE.
 Form/Format    HLA-DRB1 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
 Other Notes    Small volumes of HLA-DRB1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for HLA-DRB1 recombinant protein

   Description: HLA-DRB1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 219 amino acids (30-227 a.a) and having a molecular mass of 25.2kDa.HLA-DRB1 is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: Major Histocompatibility Complex Class II DR Beta 1 also known as HLA-DRB1 ia a member of the HLA class II beta chain paralogs. Molecule class II is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. HLA-DRB1 takes an essential part in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Furthermore, the beta chain is approximately 26- 28 kDa. It is encoded by 6 exons. While exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail.
 Product Categories/Family for HLA-DRB1 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Major Histocompatibility Complex
NCBI/Uniprot data below describe general gene information for HLA-DRB1. It may not necessarily be applicable to this product.
 NCBI GI #    155030211
 NCBI GeneID    3123
 NCBI Accession #    NP_002115.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002124.3 [Other Products]
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 UniProt Primary Accession #    Q29974 [Other Products]
 UniProt Secondary Accession #    O98212; Q0PGR5; Q29792; Q30120; Q30159; Q30200; Q3HUP9; Q3KTM1; Q3LA84; Q6T865; A7X5J4 [Other Products]
 UniProt Related Accession #    P01911; P01912; P04229; P20039; Q29974; Q30134; Q30167; Q5Y7A7; Q95IE3; Q9GIY3 [Other Products]
 Molecular Weight    30,030 Da
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 NCBI Official Full Name    major histocompatibility complex, class II, DR beta 1
 NCBI Official Synonym Full Names    major histocompatibility complex, class II, DR beta 1
 NCBI Official Symbol    HLA-DRB1 [Similar Products]
 NCBI Official Synonym Symbols   
SS1; DRB1; DRw10; HLA-DRB; HLA-DR1B
[Similar Products]
 NCBI Protein Information    major histocompatibility complex, class II, DR beta 1; DW2.2/DR2.2; HLA class II histocompatibility antigen, DR-1 beta chain; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR-beta cell surface glycoprotein; MHC class II HLA-DRw10-beta; MHC class II antigen; human leucocyte antigen DRB1; lymphocyte antigen DRB1
 UniProt Protein Name    HLA class II histocompatibility antigen, DRB1-16 beta chain
 UniProt Synonym Protein Names   
MHC class II antigen DRB1*16; DR-16; DR16
 Protein Family    HLA class II histocompatibility antigen
 UniProt Gene Name    HLA-DRB1 [Similar Products]
 UniProt Synonym Gene Names    DR-16; DR16 [Similar Products]
 UniProt Entry Name    2B1G_HUMAN
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 NCBI Summary for HLA-DRB1    HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]
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 UniProt Comments for HLA-DRB1    HLA-DRB1 iso2: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route; where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules; and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments; exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides; autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs; other cells of the gastrointestinal tract; such as epithelial cells; express MHC class II molecules and CD74 and act as APCs; which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen; three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs; CD74 undergoes a sequential degradation by various proteases; including CTSS and CTSL; leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells; the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules; increased acidification produces increased proteolysis and efficient peptide loading. Genetic variation in HLA-DRB1 is a cause of susceptibility to sarcoidosis type 1 (SS1). Sarcoidosis is an idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Belongs to the MHC class II family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; cell surface; membrane; late endosome membrane; integral to plasma membrane; lysosomal membrane; plasma membrane; trans-Golgi network membrane; MHC class II protein complex; external side of plasma membrane

Molecular Function: MHC class II receptor activity; peptide antigen binding

Biological Process: T-helper 1 type immune response; detection of bacterium; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class II; immunoglobulin production during immune response; T cell receptor signaling pathway; polysaccharide assembly with MHC class II protein complex; humoral immune response mediated by circulating immunoglobulin; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; peptide antigen assembly with MHC class II protein complex; regulation of interleukin-4 production; negative regulation of interferon-gamma production; T cell costimulation; immune response; protein tetramerization
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 Research Articles on HLA-DRB1    1. Analysis confirms the role of the DRB1-DQB1 haplotype in conferring Multiple sclerosis disease predisposition. of two HLA class II haplotypes associated with the disease in Sardinia, the rare predisposing DRB1*15:01-DQB1*06:02 and the widespread protective DRB1*16:01-DQB1*05:02.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HLA-DRB1 recombinant proteinDiseases associated with HLA-DRB1 recombinant protein
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >3336 publications with HLA-DRB1 and Immune System Diseases
 Autoimmune Diseases Antibodies  >2889 publications with HLA-DRB1 and Autoimmune Diseases
 Arthritis, Rheumatoid Antibodies  >1178 publications with HLA-DRB1 and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >879 publications with HLA-DRB1 and Nervous System Diseases
 Multiple Sclerosis Antibodies  >578 publications with HLA-DRB1 and Multiple Sclerosis
 Necrosis Antibodies  >350 publications with HLA-DRB1 and Necrosis
 Liver Diseases Antibodies  >337 publications with HLA-DRB1 and Liver Diseases
 Cardiovascular Diseases Antibodies  >265 publications with HLA-DRB1 and Cardiovascular Diseases
 Inflammation Antibodies  >232 publications with HLA-DRB1 and Inflammation
 Gastrointestinal Diseases Antibodies  >208 publications with HLA-DRB1 and Gastrointestinal Diseases
Organs/Tissues associated with HLA-DRB1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2506 publications with HLA-DRB1 and Blood
 Bone Antibodies  >542 publications with HLA-DRB1 and Bone
 Bone Marrow Antibodies  >470 publications with HLA-DRB1 and Bone Marrow
 Liver Antibodies  >277 publications with HLA-DRB1 and Liver
 Kidney Antibodies  >222 publications with HLA-DRB1 and Kidney
 Skin Antibodies  >189 publications with HLA-DRB1 and Skin
 Lung Antibodies  >138 publications with HLA-DRB1 and Lung
 Thyroid Antibodies  >121 publications with HLA-DRB1 and Thyroid
 Heart Antibodies  >106 publications with HLA-DRB1 and Heart
 Brain Antibodies  >100 publications with HLA-DRB1 and Brain
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