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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

MDHA recombinant protein :: Malate dehydrogenase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717367
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Malate dehydrogenase (MDHA), Recombinant Protein

 Also Known As   

Recombinant Human Malate dehydrogenase, cytoplasmic

 Product Synonym Names    Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase (EC:1.1.1.96)
 Product Gene Name   

MDHA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-333aa; Full Length
 Sequence    SEPIRVLVTG AAGQIAYSLL YSIGNGSVFG KDQPIILVLL DITPMMGVLD GVLMELQDCA LPLLKDVIAT DKEDVAFKDL DVAILVGSMP RREGMERKDL LKANVKIFKS QGAALDKYAK KSVKVIVVGN PANTNCLTAS KSAPSIPKEN FSCLTRLDHN RAKAQIALKL GVTANDVKNV IIWGNHSSTQ YPDVNHAKVK LQGKEVGVYE ALKDDSWLKG EFVTTVQQRG AAVIKARKLS SAMSAAKAIC DHVRDIWFGT PEGEFVSMGV ISDGNSYGVP DDLLYSFPVV IKNKTWKFVE GLPINDFSRE KMDLTAKELT EEKESAFEFL SS
 OMIM    154200
 3D Structure    ModBase 3D Structure for P40925
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MDHA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for MDHA recombinant protein    Metabolism
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 SDS-PAGE of MDHA recombinant protein    MDHA recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for MDHA. It may not necessarily be applicable to this product.
 NCBI GI #    312283701
 NCBI GeneID    4190
 NCBI Accession #    NP_001186040.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001199111.1 [Other Products]
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 UniProt Primary Accession #    P40925 [Other Products]
 UniProt Secondary Accession #    Q6I9V0; B2R5V5; B4DUN2; B7Z3I7; F5H098 [Other Products]
 Molecular Weight    63.6kD
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 NCBI Official Full Name    malate dehydrogenase, cytoplasmic isoform 2
 UniProt Protein Name    Malate dehydrogenase, cytoplasmic
 UniProt Synonym Protein Names   
Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase (EC:1.1.1.96)
 Protein Family    Malate dehydrogenase
 UniProt Gene Name    MDH1 [Similar Products]
 UniProt Synonym Gene Names    MDHA [Similar Products]
 UniProt Entry Name    MDHC_HUMAN
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 NCBI Summary for MDHA    This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016]
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 UniProt Comments for MDHA    MDH1: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

Protein type: Oxidoreductase; Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.37; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.96

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: centrosome; cytoplasm; cytosol; extracellular space; mitochondrion; myelin sheath

Molecular Function: diiodophenylpyruvate reductase activity; L-malate dehydrogenase activity; malic enzyme activity; NAD binding; protein binding

Biological Process: carbohydrate metabolic process; gluconeogenesis; glucose metabolic process; malate metabolic process; NADH metabolic process; oxaloacetate metabolic process; positive regulation of defense response to virus by host; tricarboxylic acid cycle
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Product References and Citations for MDHA recombinant protein

   Molecular cloning and mapping of a human cDNA for cytosolic malate dehydrogenase (MDH1)
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 Research Articles on MDHA    1. Proliferating cells rely on both MDH1 and LDH to replenish cytosolic NAD.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MDHA recombinant proteinPathways associated with MDHA recombinant protein
 Reference Product  PubMed Publications
 MDH2 recombinant protein  >37 publications with MDHA and MDH2
 PGM1 recombinant protein  >13 publications with MDHA and PGM1
 ME1 recombinant protein  >6 publications with MDHA and ME1
 GOT1 recombinant protein  >5 publications with MDHA and GOT1
 GOT2 recombinant protein  >3 publications with MDHA and GOT2
 ACLY recombinant protein  >2 publications with MDHA and ACLY
 Products by Pathway  Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway antibodies  Citrate Cycle (TCA Cycle, Krebs Cycle) Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway antibodies  Citrate Cycle, Second Carbon Oxidation, 2-oxoglutarate => Oxaloacetate Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
 Cysteine And Methionine Metabolism Pathway antibodies  Cysteine And Methionine Metabolism Pathway Diagram
Diseases associated with MDHA recombinant proteinOrgans/Tissues associated with MDHA recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with MDHA and Nervous System Diseases
 Brain Diseases Antibodies  >4 publications with MDHA and Brain Diseases
 Disease Models, Animal Antibodies  >3 publications with MDHA and Disease Models, Animal
 Heart Diseases Antibodies  >2 publications with MDHA and Heart Diseases
 Vascular Diseases Antibodies  >2 publications with MDHA and Vascular Diseases
 Seizures Antibodies  >1 publications with MDHA and Seizures
 Prenatal Injuries Antibodies  >1 publications with MDHA and Prenatal Injuries
 Neurobehavioral Manifestations Antibodies  >1 publications with MDHA and Neurobehavioral Manifestations
 Fibrosis Antibodies  >1 publications with MDHA and Fibrosis
 Kidney Diseases Antibodies  >1 publications with MDHA and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with MDHA and Blood
 Brain Antibodies  >10 publications with MDHA and Brain
 Muscle Antibodies  >7 publications with MDHA and Muscle
 Liver Antibodies  >5 publications with MDHA and Liver
 Heart Antibodies  >4 publications with MDHA and Heart
 Kidney Antibodies  >3 publications with MDHA and Kidney
 Lung Antibodies  >3 publications with MDHA and Lung
 Nerve Antibodies  >3 publications with MDHA and Nerve
 Intestine Antibodies  >3 publications with MDHA and Intestine
 Pancreas Antibodies  >2 publications with MDHA and Pancreas
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