NP_671732.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,250 Da
NCBI Official Full Name
mas-related G-protein coupled receptor member X1
NCBI Official Synonym Full Names
MAS related GPR family member X1
NCBI Protein Information
mas-related G-protein coupled receptor member X1
UniProt Protein Name
Mas-related G-protein coupled receptor member X1
UniProt Synonym Protein Names
Sensory neuron-specific G-protein coupled receptor 3/4
UniProt Synonym Gene Names
UniProt Entry Name
MRGX1_HUMAN
UniProt Comments for MRGPRX1
MRGPRX1: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR
Chromosomal Location of Human Ortholog: 11p15.1|11
Cellular Component: integral to plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: acute-phase response; G-protein coupled receptor protein signaling pathway
Research Articles on MRGPRX1
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