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DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

MMP8 recombinant protein :: Matrix Metalloproteinase 8 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031518 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $145 +1 FREE 8GB USB
0.05 mg  /  $275 +1 FREE 8GB USB
0.1 mg  /  $430 +1 FREE 8GB USB
0.2 mg  /  $525 +1 FREE 8GB USB
0.5 mg  /  $1,015 +1 FREE 8GB USB
1 mg  /  $1,515 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Matrix Metalloproteinase 8 (MMP8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Matrix Metalloproteinase 8 (MMP8)

 Product Gene Name   

MMP8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS2031518 Technical Datasheet    Technical Datasheet PDF
 OMIM    120355
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 Host    E.Coli
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 Purity/Purification    > 90%
 Concentration    Original Concentration: 200 Ug/mL (lot specific)
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 Organism Species    Rattus norvegicus (Rat)
 Source    Prokaryotic expression
 Residues    Leu212~Arg451
 Tags    N-terminal His Tag
 Subcellular Location    Secreted, Extracellular matrix
 Traits    Freeze-dried powder
 Buffer formulation    20mM Tris, 150mM NaCl, pH8.0, containing 0.01% SKL, 5% Trehalose and Proclin300.
 Predicted isoelectric point    6.9
 Predicted Molecular Mass    31.3kDa
 Accurate Molecular Mass    38kDa as determined by SDS-PAGE reducing conditions.
 Phenomenon explanation    The possible reasons that the actual band size differs from the predicted are as follows:

1.Splice variants: Alternative splicing may create different sized proteins from the same gene.
2. Relative charge: The composition of amino acids may affects the charge of the protein.
3. Post-translational modification: Phosphorylation, glycosylation, methylation etc.
4. Post-translation cleavage: Many proteins are synthesized as pro-proteins, and then cleaved to give the active form.
5. Polymerization of the target protein: Dimerization, multimerization etc.
 [ USAGE ]    Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.
Store at 2-8C for one month.
Aliquot and store at -80C for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of MMP8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for MMP8 recombinant protein   

Positive Control, Immunogen, SDS-PAGE, WB.

(May be suitable for use in other assays to be determined by the end user.)

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 SDS-Page of MMP8 recombinant protein    MMP8 recombinant protein SDS-Page image
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 Testing Data TD of MMP8 recombinant protein    MMP8 recombinant protein Testing Data TD image
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NCBI/Uniprot data below describe general gene information for MMP8. It may not necessarily be applicable to this product.
 NCBI GI #    71648770
 NCBI GeneID    4317
 NCBI Accession #    AAZ38714.1 [Other Products]
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 UniProt Secondary Accession #    Q45F99 [Other Products]
 UniProt Related Accession #    P22894 [Other Products]
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 NCBI Official Full Name    matrix metalloproteinase 8 (neutrophil collagenase)
 NCBI Official Synonym Full Names    matrix metallopeptidase 8
 NCBI Official Symbol    MMP8 [Similar Products]
 NCBI Official Synonym Symbols   
HNC; CLG1; MMP-8; PMNL-CL
[Similar Products]
 NCBI Protein Information    neutrophil collagenase
 UniProt Protein Name    Neutrophil collagenase
 UniProt Synonym Protein Names   
Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL
 Protein Family    Neutrophil collagenase
 UniProt Gene Name    MMP8 [Similar Products]
 UniProt Synonym Gene Names    CLG1; MMP-8; PMNL-CL [Similar Products]
 UniProt Entry Name    MMP8_HUMAN
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 NCBI Summary for MMP8    This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
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 UniProt Comments for MMP8    MMP8: Can degrade fibrillar type I, II, and III collagens. Belongs to the peptidase M10A family.

Protein type: EC 3.4.24.34; Secreted; Protease; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: zinc ion binding; serine-type endopeptidase activity; metalloendopeptidase activity; calcium ion binding

Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis
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 Research Articles on MMP8    1. Low levels of plasma MMP8 levels can rule out acute aortic dissection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MMP8 recombinant proteinPathways associated with MMP8 recombinant protein
 Reference Product  PubMed Publications
 MMP9 recombinant protein  >62 publications with MMP8 and MMP9
 MMP2 recombinant protein  >50 publications with MMP8 and MMP2
 MMP14 recombinant protein  >17 publications with MMP8 and MMP14
 TIMP2 recombinant protein  >12 publications with MMP8 and TIMP2
 MMP11 recombinant protein  >5 publications with MMP8 and MMP11
 MMP15 recombinant protein  >3 publications with MMP8 and MMP15
 MMP19 recombinant protein  >1 publications with MMP8 and MMP19
 ELANE recombinant protein  >1 publications with MMP8 and ELANE
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
Diseases associated with MMP8 recombinant proteinOrgans/Tissues associated with MMP8 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >84 publications with MMP8 and Inflammation
 Cardiovascular Diseases Antibodies  >43 publications with MMP8 and Cardiovascular Diseases
 Fibrosis Antibodies  >27 publications with MMP8 and Fibrosis
 Disease Models, Animal Antibodies  >27 publications with MMP8 and Disease Models, Animal
 Necrosis Antibodies  >17 publications with MMP8 and Necrosis
 Hemorrhage Antibodies  >17 publications with MMP8 and Hemorrhage
 Lung Diseases Antibodies  >17 publications with MMP8 and Lung Diseases
 Atherosclerosis Antibodies  >16 publications with MMP8 and Atherosclerosis
 Death Antibodies  >14 publications with MMP8 and Death
 Heart Diseases Antibodies  >14 publications with MMP8 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >93 publications with MMP8 and Blood
 Connective Tissue Antibodies  >16 publications with MMP8 and Connective Tissue
 Skin Antibodies  >14 publications with MMP8 and Skin
 Liver Antibodies  >11 publications with MMP8 and Liver
 Bone Marrow Antibodies  >9 publications with MMP8 and Bone Marrow
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