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ACADM recombinant protein :: Medium-chain specific acyl-CoA dehydrogenase, mitochondrial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS957818
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $135 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $915 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,045 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,230 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,295 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,325 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,395 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,905 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,955 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,115 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,515 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

 Product Synonym Names    MCAD
 Product Gene Name   

ACADM recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS957818 COA    COA PDF
 Sequence Positions    26-421aa; Full Length
 Sequence    KANRQREPGL GFSFEFTEQQ KEFQATARKF AREEIIPVAA EYDKTGEYPV PLIRRAWELG LMNTHIPENC GGLGLGTFDA CLISEELAYG CTGVQTAIEG NSLGQMPIII AGNDQQKKKY LGRMTEEPLM CAYCVTEPGA GSDVAGIKTK AEKKGDEYII NGQKMWITNG GKANWYFLLA RSDPDPKAPA NKAFTGFIVE ADTPGIQIGR KELNMGQRCS DTRGIVFEDV KVPKENVLIG DGAGFKVAMG AFDKTRPVVA AGAVGLAQRA LDEATKYALE RKTFGKLLVE HQAISFMLAE MAMKVELARM SYQRAAWEVD SGRRNTYYAS IAKAFAGDIA NQLATDAVQI LGGNGFNTEY PVEKLMRDAK IYQIYEGTSQ IQRLIVAREH IDKYKN
 OMIM    201450
 3D Structure    ModBase 3D Structure for P11310
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ACADM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ACADM recombinant protein

   This enzyme is specific for acyl chain lengths of 4 to 16.
 Product Categories/Family for ACADM recombinant protein    Cancer
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 SDS-PAGE of ACADM recombinant protein    ACADM recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ACADM. It may not necessarily be applicable to this product.
 NCBI GI #    4557231
 NCBI GeneID    34
 NCBI Accession #    NP_000007.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000016.5 [Other Products]
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 UniProt Primary Accession #    P11310 [Other Products]
 UniProt Secondary Accession #    Q5T4U4; Q9NYF1 [Other Products]
 UniProt Related Accession #    P11310 [Other Products]
 Molecular Weight    47.72kD
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 NCBI Official Full Name    medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform a
 NCBI Official Synonym Full Names    acyl-CoA dehydrogenase, C-4 to C-12 straight chain
 NCBI Official Symbol    ACADM [Similar Products]
 NCBI Official Synonym Symbols   
MCAD; ACAD1; MCADH
[Similar Products]
 NCBI Protein Information    medium-chain specific acyl-CoA dehydrogenase, mitochondrial
 UniProt Protein Name    Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
 Protein Family    Medium-chain specific acyl-CoA dehydrogenase
 UniProt Gene Name    ACADM [Similar Products]
 UniProt Synonym Gene Names    MCAD [Similar Products]
 UniProt Entry Name    ACADM_HUMAN
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 NCBI Summary for ACADM    This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACADM    ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.3.8.7; Mitochondrial; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - propanoate; Oxidoreductase; Lipid Metabolism - fatty acid; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: axon; mitochondrial matrix; mitochondrion; nucleus; peroxisome

Molecular Function: acyl-CoA binding; acyl-CoA dehydrogenase activity; electron carrier activity; FAD binding; identical protein binding

Biological Process: carnitine biosynthetic process; carnitine metabolic process, CoA-linked; cellular lipid metabolic process; fatty acid beta-oxidation; fatty acid beta-oxidation using acyl-CoA dehydrogenase; lipid homeostasis; medium-chain fatty acid catabolic process; medium-chain fatty acid metabolic process

Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of
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Product References and Citations for ACADM recombinant protein

   "Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue." Kelly D.P., Kim J.-J.P., Billadello J.J., Hainline B.E., Chu T.W., Strauss A.W. Proc. Natl. Acad. Sci. U.S.A. 84:4068-4072(1987)
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 Research Articles on ACADM    1. our study demonstrates that not all mutations identified in children with abnormal NBS profiles suggestive of MCAD deficiency result in a total loss in MCAD activity and function
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ACADM recombinant proteinPathways associated with ACADM recombinant protein
 Reference Product  PubMed Publications
 EHHADH recombinant protein  >2 publications with ACADM and EHHADH
 ACAA1 recombinant protein  >1 publications with ACADM and ACAA1
 ECHS1 recombinant protein  >1 publications with ACADM and ECHS1
 ACAA2 recombinant protein  >1 publications with ACADM and ACAA2
 HADHB recombinant protein  >1 publications with ACADM and HADHB
 HADHA recombinant protein  >1 publications with ACADM and HADHA
 Products by Pathway  Pathway Diagram
 Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway antibodies  Beta Oxidation Of Decanoyl-CoA To Octanoyl-CoA-CoA Pathway Diagram
 Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway antibodies  Beta Oxidation Of Octanoyl-CoA To Hexanoyl-CoA Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Degradation Pathway antibodies  Fatty Acid Degradation Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
 Fatty Acid Metabolism Pathway antibodies  Fatty Acid Metabolism Pathway Diagram
Diseases associated with ACADM recombinant proteinOrgans/Tissues associated with ACADM recombinant protein
 Disease Name  Pubmed Publications
 Medium chain acyl CoA dehydrogenase deficiency Antibodies  >27 publications with ACADM and Medium chain acyl CoA dehydrogenase deficiency
 Fatty Liver Antibodies  >13 publications with ACADM and Fatty Liver
 Liver Diseases Antibodies  >6 publications with ACADM and Liver Diseases
 Obesity Antibodies  >5 publications with ACADM and Obesity
 Insulin Resistance Antibodies  >4 publications with ACADM and Insulin Resistance
 Cardiovascular Diseases Antibodies  >4 publications with ACADM and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with ACADM and Inflammation
 Heart Diseases Antibodies  >3 publications with ACADM and Heart Diseases
 Hepatomegaly Antibodies  >3 publications with ACADM and Hepatomegaly
 Fibrosis Antibodies  >2 publications with ACADM and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >19 publications with ACADM and Blood
 Liver Antibodies  >15 publications with ACADM and Liver
 Muscle Antibodies  >6 publications with ACADM and Muscle
 Heart Antibodies  >5 publications with ACADM and Heart
 Adipose Tissue Antibodies  >5 publications with ACADM and Adipose Tissue
 Connective Tissue Antibodies  >4 publications with ACADM and Connective Tissue
 Kidney Antibodies  >3 publications with ACADM and Kidney
 Thyroid Antibodies  >2 publications with ACADM and Thyroid
 Vascular Antibodies  >2 publications with ACADM and Vascular
 Lung Antibodies  >2 publications with ACADM and Lung
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