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PMEL recombinant protein :: Melanocyte protein PMEL Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS952140
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,080 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,330 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,375 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,970 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,010 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,595 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Melanocyte protein PMEL, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Melanocyte protein PMEL

 Product Synonym Names    ME20-M; ME20M; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; P1; P100; Premelanosome protein; Silver locus protein homolog
 Product Gene Name   

PMEL recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS952140 COA    COA PDF
 Sequence Positions    25-467. Partial, provide the M-alpha chain
 Sequence    KVPRNQDWLG VSRQLRTKAW NRQLYPEWTE AQRLDCWRGG QVSLKVSNDG PTLIGANASF SIALNFPGSQ KVLPDGQVIW VNNTIINGSQ VWGGQPVYPQ ETDDACIFPD GGPCPSGSWS QKRSFVYVWK TWGQYWQVLG GPVSGLSIGT GRAMLGTHTM EVTVYHRRGS RSYVPLAHSS SAFTITDQVP FSVSVSQLRA LDGGNKHFLR NQPLTFALQL HDPSGYLAEA DLSYTWDFGD SSGTLISRAL VVTHTYLEPG PVTAQVVLQA AIPLTSCGSS PVPGTTDGHR PTAEAPNTTA GQVPTTEVVG TTPGQAPTAE PSGTTSVQVP TTEVISTAPV QMPTAESTGM TPEKVPVSEV MGTTLAEMST PEATGMTPAE VSIVVLSGTT AAQVTTTEWV ETTARELPIP EPEGPDASSI MSTESITGSL GPLLDGTATL RLV
 OMIM    155550
 3D Structure    ModBase 3D Structure for P40967
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PMEL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PMEL recombinant protein

   Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
 Product Categories/Family for PMEL recombinant protein    Metabolism
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 SDS-PAGE of PMEL recombinant protein    PMEL recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for PMEL. It may not necessarily be applicable to this product.
 NCBI GI #    318037593
 NCBI GeneID    6490
 NCBI Accession #    NP_001186982.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001200053.1 [Other Products]
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 UniProt Primary Accession #    P40967 [Other Products]
 UniProt Secondary Accession #    Q12763; Q14448; Q14817; Q16565; B3KS57; B7Z6D7 [Other Products]
 UniProt Related Accession #    P40967 [Other Products]
 Molecular Weight    63kD
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 NCBI Official Full Name    melanocyte protein PMEL isoform 2
 NCBI Official Synonym Full Names    premelanosome protein
 NCBI Official Symbol    PMEL [Similar Products]
 NCBI Official Synonym Symbols   
P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E
[Similar Products]
 NCBI Protein Information    melanocyte protein PMEL
 UniProt Protein Name    Melanocyte protein PMEL
 UniProt Synonym Protein Names   
ME20-M; ME20M
 Protein Family    Melanocyte protein
 UniProt Gene Name    PMEL [Similar Products]
 UniProt Synonym Gene Names    D12S53E; PMEL17; SILV; ME20M; ME20-S; ME20S [Similar Products]
 UniProt Entry Name    PMEL_HUMAN
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 NCBI Summary for PMEL    This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
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 UniProt Comments for PMEL    SILV: Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. Belongs to the PMEL/NMB family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 12q13-q14

Cellular Component: endoplasmic reticulum membrane; extracellular region; Golgi apparatus; integral to membrane; melanosome; plasma membrane

Molecular Function: protein binding

Biological Process: melanin biosynthetic process; melanosome organization and biogenesis
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Product References and Citations for PMEL recombinant protein

   A melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12.Kwon B.S., Chintamaneni C., Kozak C.A., Copeland N.G., Gilbert D.J., Jenkins N.A., Barton D., Francke U., Kobayashi Y., Kim K.-K.Proc. Natl. Acad. Sci. U.S.A. 88:9228-9232(1991)
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 Research Articles on PMEL    1. Data indicate that repeat domain (RPT) derived from Pmel17 aggregation kinetics were influenced only by lysolipid-containing phospholipid vesicles.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PMEL recombinant proteinDiseases associated with PMEL recombinant protein
 Reference Product  PubMed Publications
 MLANA recombinant protein  >130 publications with PMEL and MLANA
 TYRP1 recombinant protein  >38 publications with PMEL and TYRP1
 MITF recombinant protein  >28 publications with PMEL and MITF
 MAGEA3 recombinant protein  >25 publications with PMEL and MAGEA3
 TYR recombinant protein  >13 publications with PMEL and TYR
 Disease Name  Pubmed Publications
 Neoplasms, Experimental Antibodies  >96 publications with PMEL and Neoplasms, Experimental
 Disease Models, Animal Antibodies  >88 publications with PMEL and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >54 publications with PMEL and Neoplasm Metastasis
 Necrosis Antibodies  >17 publications with PMEL and Necrosis
 Inflammation Antibodies  >8 publications with PMEL and Inflammation
 Leukopenia Antibodies  >6 publications with PMEL and Leukopenia
 Pain Antibodies  >5 publications with PMEL and Pain
 Breast Neoplasms Antibodies  >5 publications with PMEL and Breast Neoplasms
 Kidney Diseases Antibodies  >5 publications with PMEL and Kidney Diseases
 Fever Antibodies  >4 publications with PMEL and Fever
Organs/Tissues associated with PMEL recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >132 publications with PMEL and Skin
 Lung Antibodies  >24 publications with PMEL and Lung
 Eye Antibodies  >23 publications with PMEL and Eye
 Spleen Antibodies  >19 publications with PMEL and Spleen
 Brain Antibodies  >16 publications with PMEL and Brain
 Kidney Antibodies  >12 publications with PMEL and Kidney
 Liver Antibodies  >10 publications with PMEL and Liver
 Bone Antibodies  >10 publications with PMEL and Bone
 Testis Antibodies  >8 publications with PMEL and Testis
 Muscle Antibodies  >8 publications with PMEL and Muscle
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