Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow MIA  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • ACADL Antibody
 • CCND2 Recombinant Protein
 • C-MYC Antibody
 • Bacillus subtilis Subtilisin Antibody
 • Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Antibody
 • Aldolase A (ALDOA) Recombinant Protein
 • transmembrane 4 L six family member 19 (TM4SF19) ELISA Kit
 • ORP150 Antibody
 • mitogen-activated protein kinase 10 (MAPK10) Antibody
 • Tubulin Antibody
 • ISG15 Antibody
 • INFLUENZA B NUCLEOPROTEIN Antibody
 • GNAS Antibody
 • Epstein Barr Virus, Latent Membrane Protein 2A Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

MIA recombinant protein :: Melanoma Inhibitory Activity Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142187 MIA recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,435 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Melanoma Inhibitory Activity (MIA), Recombinant Protein

 Also Known As   

Recombinant Human Melanoma Inhibitory Activity Protein

 Product Synonym Names    MIA Human; Melanoma Inhibitory Activity Human Recombinant; Melanoma-derived growth regulatory protein precursor; Cartilage-derived retinoic acid-sensitive protein; CD-RAP; MIA
 Product Gene Name   

MIA recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    Agrees with the sequence of native MIA human with an addition N-terminal Methionine residue.MG PMPKLADRKL CADQECSSHP ISMAVALQDY MAPDCRFLTI HRGQVVYVFS LKGRGRFLWG GSVQGDYYGD LAARLGYFPS SIVREDQTLK VDVKTDKWDF YCQ
 OMIM    601340
 3D Structure    ModBase 3D Structure for Q16674
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    The protein was lyophilized from a concentrated (1mg/ml) solution containing 20mM Potassium-phosphate pH=7 and 150mM potassium chloride.
Sterile Filtered White lyophilized (freeze-dried) powder.
Section Bar
 Solubility    It is recommended to reconstitute the lyophilized Melanoma Inhibitory Activity in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Protein Content    UV spectroscopy at 280 nm using the absorption coefficient of 19300 M-1cm-1.
 Biological Activity    The biological activity is calculated by the inhibiting effect on the invasion of Mel In Tumor cells and found active in Mel In assay.
Section Bar
 Preparation and Storage    Lyophilized MIA although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution MIA should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of MIA recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for MIA recombinant protein

   Description: Melanoma Inhibitory Activity Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain consisting of 108 amino having a total molecular mass of 12237 Dalton.The MIA is purified by proprietary chromatographic techniques.

Introduction: The Melanoma Inhibitory protein (MIA) was identified as an inhibitor of in vitro growth of malignant melanoma cells. The protein contains a SH3 domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion. In a study of human melanoma cell lines with different metastatic capacity MIA mRNA expression appeared to be inversely correlated with pigmentation. MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas.
 Product Categories/Family for MIA recombinant protein    CYTOKINES AND GROWTH FACTORS; Growth Factors; Melanoma Inhibitory Activity
NCBI/Uniprot data below describe general gene information for MIA. It may not necessarily be applicable to this product.
 NCBI GI #    321400133
 NCBI GeneID    8190
 NCBI Accession #    NP_001189482.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001202553.1 [Other Products]
Section Bar
 UniProt Primary Accession #    Q16674 [Other Products]
 UniProt Secondary Accession #    Q6FHV3 [Other Products]
 UniProt Related Accession #    Q16674 [Other Products]
 Molecular Weight    6,361 Da
Table BarTOPTable Bar
 NCBI Official Full Name    melanoma-derived growth regulatory protein
 NCBI Official Synonym Full Names    melanoma inhibitory activity
 NCBI Official Symbol    MIA [Similar Products]
 NCBI Official Synonym Symbols   
CD-RAP
[Similar Products]
 NCBI Protein Information    melanoma-derived growth regulatory protein
 UniProt Protein Name    Melanoma-derived growth regulatory protein
 UniProt Synonym Protein Names   
Melanoma inhibitory activity protein
 Protein Family    Melanoma inhibitory activity protein
 UniProt Gene Name    MIA [Similar Products]
 UniProt Entry Name    MIA_HUMAN
Section Bar
 UniProt Comments for MIA    MIA: Elicits growth inhibition on melanoma cells in vitro as well as some other neuroectodermal tumors, including gliomas. Belongs to the MIA/OTOR family.

Protein type: Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space

Molecular Function: growth factor activity

Biological Process: cell proliferation
Table BarTOPTable Bar
 Research Articles on MIA    1. The effects of MIA/CD-RAP on transcriptional regulation in chondrocytes, through the regulation of p54(nrb) via YBX1 contributes to the understanding of chondrogenesis.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with MIA recombinant proteinPathways associated with MIA recombinant protein
 Reference Product  PubMed Publications
 TGFB1 recombinant protein  >9 publications with MIA and TGFB1
 HMG1 recombinant protein  >5 publications with MIA and HMG1
 HMGB1 recombinant protein  >5 publications with MIA and HMGB1
 SPP1 recombinant protein  >5 publications with MIA and SPP1
 IGF1 recombinant protein  >1 publications with MIA and IGF1
 CDH7 recombinant protein  >1 publications with MIA and CDH7
 Products by Pathway  Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
Diseases associated with MIA recombinant proteinOrgans/Tissues associated with MIA recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >128 publications with MIA and Inflammation
 Necrosis Antibodies  >98 publications with MIA and Necrosis
 Neoplasms, Experimental Antibodies  >78 publications with MIA and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >67 publications with MIA and Lung Neoplasms
 Liver Neoplasms Antibodies  >61 publications with MIA and Liver Neoplasms
 Breast Neoplasms Antibodies  >58 publications with MIA and Breast Neoplasms
 Kidney Diseases Antibodies  >58 publications with MIA and Kidney Diseases
 Atherosclerosis Antibodies  >52 publications with MIA and Atherosclerosis
 Liver Diseases Antibodies  >44 publications with MIA and Liver Diseases
 Heart Diseases Antibodies  >39 publications with MIA and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >120 publications with MIA and Lung
 Skin Antibodies  >107 publications with MIA and Skin
 Heart Antibodies  >68 publications with MIA and Heart
 Lymph Node Antibodies  >50 publications with MIA and Lymph Node
 Prostate Antibodies  >47 publications with MIA and Prostate
 Stomach Antibodies  >25 publications with MIA and Stomach
 Placenta Antibodies  >18 publications with MIA and Placenta
 Embryonic Tissue Antibodies  >18 publications with MIA and Embryonic Tissue
 Eye Antibodies  >14 publications with MIA and Eye
 Ear Antibodies  >7 publications with MIA and Ear
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions