NP_000235.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
63,748 Da
NCBI Official Full Name
menin isoform 1
NCBI Official Synonym Full Names
menin 1
NCBI Official Synonym Symbols
NCBI Protein Information
menin
UniProt Protein Name
Menin
UniProt Synonym Gene Names
NCBI Summary for MEN1
This gene encodes menin, a putative tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. In vitro studies have shown menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD, however, the function of this protein is not known. Two messages have been detected on northern blots but the larger message has not been characterized. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
UniProt Comments for MEN1
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (). May be involved in DNA repair.
Research Articles on MEN1
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Products associated with MEN1 recombinant protein
Pathways associated with MEN1 recombinant protein
Diseases associated with MEN1 recombinant protein
Organs/Tissues associated with MEN1 recombinant protein
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