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NF2 recombinant protein :: Merlin (NF2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS956203 NF2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $1,075 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,200 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,450 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,460 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,525 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,650 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,180 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,185 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,495 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,860 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Merlin (NF2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Merlin (NF2)

 Product Gene Name   

NF2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS956203 COA    COA PDF
 Sequence Positions    1-595aa, Full Length
 Sequence    MAGAIASRMS FSSLKRKQPK TFTVRIVTMD AEMEFNCEMK WKGKDLFDLV CRTLGLRETW FFGLQYTIKD TVAWLKMDKK VLDHDVSKEE PVTFHFLAKF YPENAEEELV QEITQHLFFL QVKKQILDEK IYCPPEASVL LASYAVQAKY GDYDPSVHKR GFLAQEELLP KRVINLYQMT PEMWEERITA WYAEHRGRAR DEAEMEYLKI AQDLEMYGVN YFAIRNKKGT ELLLGVDALG LHIYDPENRL TPKISFPWNE IRNISYSDKE FTIKPLDKKI DVFKFNSSKL RVNKLILQLC IGNHDLFMRR RKADSLEVQQ MKAQAREEKA RKQMERQRLA REKQMREEAE RTRDELERRL LQMKEEATMA NEALMRSEET ADLLAEKAQI TEEEAKLLAQ KAAEAEQEMQ RIKATAIRTE EEKRLMEQKV LEAEVLALKM AEESERRAKE ADQLKQDLQE AREAERRAKQ KLLEIATKPT YPPMNPIPAP LPPDIPSFNL IGDSLSFDFK DTDMKRLSME IEKEKVEYME KSKHLQEQLN ELKTEIEALK LKERETALDI LHNENSDRGG SSKHNTIKKL TLQSAKSRVA FFEEL
 OMIM    101000
 3D Structure    ModBase 3D Structure for P35240
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 85% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NF2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NF2 recombinant protein

   Probable regulator of the Hippo
SWH (Sav
Wts
Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo
SWH (Sav
Wts
Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP
DCAF1 E3 ubiquitin-protein ligase complex.
 Product Categories/Family for NF2 recombinant protein    Cancer
NCBI/Uniprot data below describe general gene information for NF2. It may not necessarily be applicable to this product.
 NCBI GI #    4557795
 NCBI GeneID    4771
 NCBI Accession #    NP_000259.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000268.3 [Other Products]
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 UniProt Primary Accession #    P35240 [Other Products]
 UniProt Secondary Accession #    O95683; Q8WUJ2; Q969N0; Q969Q3; Q96T30; Q96T31; Q96T32; Q96T33; Q9BTW3; Q9UNG9; Q9UNH3 [Other Products]
 UniProt Related Accession #    P35240 [Other Products]
 Molecular Weight    73.7 kDa
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 NCBI Official Full Name    merlin isoform 1
 NCBI Official Synonym Full Names    neurofibromin 2
 NCBI Official Symbol    NF2 [Similar Products]
 NCBI Official Synonym Symbols   
ACN; SCH; BANF
[Similar Products]
 NCBI Protein Information    merlin
 UniProt Protein Name    Merlin
 UniProt Synonym Protein Names   
Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin
 Protein Family    Merlin
 UniProt Gene Name    NF2 [Similar Products]
 UniProt Synonym Gene Names    SCH [Similar Products]
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 NCBI Summary for NF2    This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NF2    Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
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Product References and Citations for NF2 recombinant protein

   "Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2." Rouleau G.A., Merel P., Lutchman M., Sanson M., Zucman J., Marineau C., Hoang-Xuan K., Demczuk S., Desmaze C., Plougastel B., Pulst S., Lenoir G., Bijlsma E., Fashold R., Dumanski J.P., de Jong P., Parry D., Eldrige R. Thomas G. Nature 363:515-521(1993)
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 Research Articles on NF2    1. In this study, the authors perform an exome, methylation and RNA-seq analysis of 31 cases of radiation-induced meningioma and show NF2 rearrangement, an observation previously unreported in the sporadic tumors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NF2 recombinant proteinPathways associated with NF2 recombinant protein
 Reference Product  PubMed Publications
 ERBB2 recombinant protein  >17 publications with NF2 and ERBB2
 CD44 recombinant protein  >16 publications with NF2 and CD44
 PAK1 recombinant protein  >9 publications with NF2 and PAK1
 CTNNB1 recombinant protein  >8 publications with NF2 and CTNNB1
 TSC1 recombinant protein  >4 publications with NF2 and TSC1
 SCHIP1 recombinant protein  >3 publications with NF2 and SCHIP1
 RALGDS recombinant protein  >2 publications with NF2 and RALGDS
 PXN recombinant protein  >2 publications with NF2 and PXN
 SDCBP recombinant protein  >1 publications with NF2 and SDCBP
 SPTBN1 recombinant protein  >1 publications with NF2 and SPTBN1
 Products by Pathway  Pathway Diagram
 ErbB2/ErbB3 Signaling Events Pathway antibodies  ErbB2/ErbB3 Signaling Events Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with NF2 recombinant proteinOrgans/Tissues associated with NF2 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >984 publications with NF2 and Neoplasms
 Nervous System Diseases Antibodies  >866 publications with NF2 and Nervous System Diseases
 Neurofibromatosis 2 Antibodies  >776 publications with NF2 and Neurofibromatosis 2
 Meningioma Antibodies  >246 publications with NF2 and Meningioma
 Schwannomatosis Antibodies  >74 publications with NF2 and Schwannomatosis
 Mesothelioma Antibodies  >57 publications with NF2 and Mesothelioma
 Meningioma, familial Antibodies  >54 publications with NF2 and Meningioma, familial
 Eye Diseases Antibodies  >50 publications with NF2 and Eye Diseases
 Skin Neoplasms Antibodies  >43 publications with NF2 and Skin Neoplasms
 Carcinoma Antibodies  >38 publications with NF2 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >276 publications with NF2 and Brain
 Skin Antibodies  >60 publications with NF2 and Skin
 Eye Antibodies  >45 publications with NF2 and Eye
 Bone Antibodies  >34 publications with NF2 and Bone
 Lung Antibodies  >30 publications with NF2 and Lung
 Muscle Antibodies  >29 publications with NF2 and Muscle
 Vascular Antibodies  >26 publications with NF2 and Vascular
 Liver Antibodies  >15 publications with NF2 and Liver
 Kidney Antibodies  >15 publications with NF2 and Kidney
 Embryonic Tissue Antibodies  >11 publications with NF2 and Embryonic Tissue
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