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MET recombinant protein :: Met Proto-Oncogene Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144821 MET recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $1,030 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Met Proto-Oncogene, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Met Proto-Oncogene

 Product Synonym Names    MET Human; Met Proto-Oncogene Human Recombinant
 Product Gene Name   

MET recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    DSDISSPLLQ NTVHIDLSAL NPELVQAVQH VVIGPSSLIV HFNEVIGRGH FGCVYHGTLL DNDGKKIHCA VKSLNRITDI GEVSQFLTEG IIMKDFSHPN VLSLLGICLR SEGSPLVVLP YMKHGDLRNF IRNETHNPTV KDLIGFGLQV AKGMKYLASK KFVHRDLAAR NCMLDEKFTV KVADFGLARD MYDKEYYSVH NKTGAKLPVK WMALESLQTQ KFTTKSDVWS FGVLLWELMT RGAPPYPDVN TFDITVYLLQ GRRLLQPEYC PDPLYEVMLK CWHPKAEMRP SFSELVSRIS AIFSTFI.
 OMIM    114550
 3D Structure    ModBase 3D Structure for P08581
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 Host    Insect Cells
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 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    MET protein (1mg/ml) is supplied in 50mM Tris, 300mM NaCl, 10% Glycerol, pH 7.5.
Sterile Filtered clear colorless solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be lIsed within 2-4 weeks.
Store, frozen at -20 degree C for longer periods of time .
Please avoid freeze thaw cycles,
 Other Notes    Small volumes of MET recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MET recombinant protein

   Description: Met Proto-Oncogene Human Recombinant produced in Insect cells amino acids 1039-1345, having a molecular weight of 34.6kDa.c-MET is purified by proprietary chromatographic techniques.

Introduction: Mesenchymal epithelial transition factor (c-MET) is a proto-oncogenic receptor tyrosine kinase. The endogenous ligand for c-MET is HGF (hepatocyte growth factor), which is a disulfide-linked heterodimeric molecule produced predominantly by mesenchymal cells. In the adult, c-MET protein expression is limited to stem and progenitor cells and is required for wound healing and hepatocyte regeneration. In the embryo, c-MET receptors are expressed on cells of epithelial origin, which are vital for invasive growth and mediate epithelial-mesenchymal transition (EMT). Abnormal activation of the HGF/MET pathway leads to a variety of cancers. c-MET mutation is linked with a poor prognosis since it can trigger tumor growth, angiogenesis and metastasis.
 Product Categories/Family for MET recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Met Proto-Oncogene
NCBI/Uniprot data below describe general gene information for MET. It may not necessarily be applicable to this product.
 NCBI GI #    42741655
 NCBI GeneID    4233
 NCBI Accession #    NP_000236.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000245.2 [Other Products]
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 UniProt Primary Accession #    P08581 [Other Products]
 UniProt Secondary Accession #    O60366; Q12875; Q9UDX7; Q9UPL8; A1L467; B5A932; E7EQ94 [Other Products]
 UniProt Related Accession #    P08581 [Other Products]
 Molecular Weight    85,745 Da
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 NCBI Official Full Name    hepatocyte growth factor receptor isoform b
 NCBI Official Synonym Full Names    MET proto-oncogene, receptor tyrosine kinase
 NCBI Official Symbol    MET [Similar Products]
 NCBI Official Synonym Symbols   
HGFR; AUTS9; RCCP2; c-Met
[Similar Products]
 NCBI Protein Information    hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met
 UniProt Protein Name    Hepatocyte growth factor receptor
 UniProt Synonym Protein Names   
HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
 Protein Family    Hepatocyte growth factor receptor
 UniProt Gene Name    MET [Similar Products]
 UniProt Synonym Gene Names    HGF receptor; SF receptor [Similar Products]
 UniProt Entry Name    MET_HUMAN
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 NCBI Summary for MET    The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MET    Met: a proto-oncogenic receptor tyrosine kinase with high affinity for hepatocyte growth factor. The primary single chain precursor protein is post-translationally cleaved to produce the 45 kDa alpha- and 145 kDa beta-subunits, which are disulfide linked to form the mature receptor. Ligand-binding induces autophosphorylation at multiple tyrosines, which recruit several downstream signaling components, including Gab1, c-Cbl and PI3 kinase. Activating point mutations cause hereditary papillary renal carcinoma. Mutations also seen in sporadic renal cell carcinoma and childhood hepatocellular carcinoma. Upregulation in carcinomas and sarcomas correlates with metastasis and poor outcome. Some gastric carcinomas harbor a translocation that creates an activated TPR-Met fusion protein. A small molecule inhibitor (PHA-665752) shows an effect in gastric carcinoma xenografts. Inhibitors: SU11274, PHA-665752, mAbs. Two alternatively spliced human isoforms have been reported.

Protein type: Membrane protein, integral; Oncoprotein; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; TK group; Met family

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: cell surface; integral to plasma membrane; integral to membrane; plasma membrane; extracellular region; basal plasma membrane

Molecular Function: protein binding; protein-tyrosine kinase activity; hepatocyte growth factor receptor activity; protein phosphatase binding; ATP binding

Biological Process: axon guidance; skeletal muscle development; peptidyl-tyrosine phosphorylation; activation of MAPK activity; myoblast proliferation; protein amino acid autophosphorylation; myotube differentiation; muscle cell migration; hepatocyte growth factor receptor signaling pathway; liver development; glucose homeostasis; signal transduction; cell proliferation; cell surface receptor linked signal transduction; positive chemotaxis; branching morphogenesis of a tube; adult behavior; positive regulation of transcription from RNA polymerase II promoter; brain development; endothelial cell morphogenesis; placenta development

Disease: Hepatocellular Carcinoma; Renal Cell Carcinoma, Papillary, 1
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 Research Articles on MET    1. Studies suggest that although serum proto-oncogene proteins c-met (MET) and hepatocyte growth factor (HGF) may serve as predictive biomarkers for MET therapeutics, data do not support their use as pharmacodynamic biomarkers for onartuzumab.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MET recombinant proteinPathways associated with MET recombinant protein
 Reference Product  PubMed Publications
 HGF recombinant protein  >2703 publications with MET and HGF
 CTNNB1 recombinant protein  >220 publications with MET and CTNNB1
 UBC recombinant protein  >158 publications with MET and UBC
 GRB2 recombinant protein  >117 publications with MET and GRB2
 GAB1 recombinant protein  >99 publications with MET and GAB1
 CBL recombinant protein  >63 publications with MET and CBL
 PAX3 recombinant protein  >43 publications with MET and PAX3
 PTPN11 recombinant protein  >29 publications with MET and PTPN11
 PTPN1 recombinant protein  >8 publications with MET and PTPN1
 PTPRJ recombinant protein  >3 publications with MET and PTPRJ
 Products by Pathway  Pathway Diagram
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 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Arf6 Signaling Events Pathway antibodies  Arf6 Signaling Events Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Bacterial Invasion Of Epithelial Cells Pathway antibodies  Bacterial Invasion Of Epithelial Cells Pathway Diagram
 Central Carbon Metabolism In Cancer Pathway antibodies  Central Carbon Metabolism In Cancer Pathway Diagram
Diseases associated with MET recombinant proteinOrgans/Tissues associated with MET recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >9077 publications with MET and Cardiovascular Diseases
 Carcinoma Antibodies  >4742 publications with MET and Carcinoma
 Heart Diseases Antibodies  >4527 publications with MET and Heart Diseases
 Inflammation Antibodies  >2403 publications with MET and Inflammation
 Adenocarcinoma Antibodies  >2188 publications with MET and Adenocarcinoma
 Liver Diseases Antibodies  >2102 publications with MET and Liver Diseases
 Kidney Diseases Antibodies  >1833 publications with MET and Kidney Diseases
 Schizophrenia Antibodies  >1809 publications with MET and Schizophrenia
 Breast Neoplasms Antibodies  >1778 publications with MET and Breast Neoplasms
 Lung Neoplasms Antibodies  >1549 publications with MET and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8762 publications with MET and Brain
 Heart Antibodies  >5922 publications with MET and Heart
 Bone Antibodies  >4647 publications with MET and Bone
 Lung Antibodies  >4326 publications with MET and Lung
 Vascular Antibodies  >4170 publications with MET and Vascular
 Liver Antibodies  >4066 publications with MET and Liver
 Muscle Antibodies  >3849 publications with MET and Muscle
 Kidney Antibodies  >2925 publications with MET and Kidney
 Skin Antibodies  >2319 publications with MET and Skin
 Eye Antibodies  >1835 publications with MET and Eye
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