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TIMP2 recombinant protein :: Metalloproteinase inhibitor 2 protein (TIMP2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969134
SDS-PAGE
Unit / Price
0.002 mg  /  $115 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $720 +1 FREE 8GB USB
0.25 mg  /  $1,230 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Metalloproteinase inhibitor 2 protein (TIMP2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Metalloproteinase inhibitor 2 protein (TIMP2)

 Product Synonym Names    CSC-21K; TIMP-2
 Product Gene Name   

TIMP2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    27-220aa, Full Length of Mature Protein
 Sequence    CSCSPVHPQQ AFCNADVVIR AKAVSEKEVD SGNDIYGNPI KRIQYEIKQI KMFKGPEKDI EFIYTAPSSA VCGVSLDVGG KKEYLIAGKA EGDGKMHITL CDFIVPWDTL STTQKKSLNH RYQMGCECKI TRCPMIPCYI SSPDECLWMD WVTEKNINGH QAKFFACIKR SDGSCAWYRG AAPPKQEFLD IEDP
 OMIM    J05593 mRNA
 3D Structure    ModBase 3D Structure for P16035
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 Host    E Coli
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 Purity/Purification    >=95% as determined by SDS-PAGE and HPLC. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Storage Buffer    0.2 um filtered PBS, pH 7.4, with 3 % trehalose,lyophilized
 Endotoxin    Less than 1.0 EU/ug as determined by LAL method.
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 Preparation and Storage    Generally, the shelf life of liquid form is 6 months at -20/-80 degree C. The shelf life of lyophilized form is 12 months at -20/-80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TIMP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TIMP2 recombinant protein

   Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}.
 Product Categories/Family for TIMP2 recombinant protein    Cancer; Enzyme
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 SDS-PAGE of TIMP2 recombinant protein    TIMP2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for TIMP2. It may not necessarily be applicable to this product.
 NCBI GI #    4507511
 NCBI GeneID    7077
 NCBI Accession #    NP_003246.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003255.4 [Other Products]
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 UniProt Primary Accession #    P16035 [Other Products]
 UniProt Secondary Accession #    Q16121; Q93006; Q9UDF7 [Other Products]
 UniProt Related Accession #    P16035 [Other Products]
 Molecular Weight    21.8 kDa
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 NCBI Official Full Name    metalloproteinase inhibitor 2
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 2
 NCBI Official Symbol    TIMP2 [Similar Products]
 NCBI Official Synonym Symbols   
DDC8; CSC-21K
[Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 2
 UniProt Protein Name    Metalloproteinase inhibitor 2
 UniProt Synonym Protein Names   
CSC-21K; Tissue inhibitor of metalloproteinases 2; TIMP-2
 Protein Family    Metalloproteinase inhibitor
 UniProt Gene Name    TIMP2 [Similar Products]
 UniProt Synonym Gene Names    TIMP-2 [Similar Products]
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 NCBI Summary for TIMP2    This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP2    TIMP2: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. Interacts (via the C-terminal) with MMP2 (via the C- terminal PEX domain); the interaction inhibits the MMP2 activity. Down-regulated by TGFB1. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Cell development/differentiation; Extracellular matrix; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: extracellular matrix; extracellular region; extracellular space; proteinaceous extracellular matrix

Molecular Function: metalloendopeptidase inhibitor activity; protease binding; protein binding

Biological Process: extracellular matrix disassembly; negative regulation of membrane protein ectodomain proteolysis; neutrophil degranulation; response to cytokine stimulus; response to hormone stimulus
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 Research Articles on TIMP2    1. High TIMP2 expression is associated with acute kidney injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TIMP2 recombinant proteinPathways associated with TIMP2 recombinant protein
 Reference Product  PubMed Publications
 MMP2 recombinant protein  >345 publications with TIMP2 and MMP2
 MMP9 recombinant protein  >210 publications with TIMP2 and MMP9
 MMP14 recombinant protein  >50 publications with TIMP2 and MMP14
 MMP13 recombinant protein  >31 publications with TIMP2 and MMP13
 MMP8 recombinant protein  >15 publications with TIMP2 and MMP8
 MMP10 recombinant protein  >14 publications with TIMP2 and MMP10
 RECK recombinant protein  >8 publications with TIMP2 and RECK
 MMP16 recombinant protein  >3 publications with TIMP2 and MMP16
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
Diseases associated with TIMP2 recombinant proteinOrgans/Tissues associated with TIMP2 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >95 publications with TIMP2 and Cardiovascular Diseases
 Neoplasm Invasiveness Antibodies  >77 publications with TIMP2 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >76 publications with TIMP2 and Neoplasm Metastasis
 Fibrosis Antibodies  >68 publications with TIMP2 and Fibrosis
 Inflammation Antibodies  >62 publications with TIMP2 and Inflammation
 Heart Diseases Antibodies  >51 publications with TIMP2 and Heart Diseases
 Disease Models, Animal Antibodies  >44 publications with TIMP2 and Disease Models, Animal
 Kidney Diseases Antibodies  >33 publications with TIMP2 and Kidney Diseases
 Necrosis Antibodies  >33 publications with TIMP2 and Necrosis
 Liver Diseases Antibodies  >33 publications with TIMP2 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >156 publications with TIMP2 and Blood
 Vascular Antibodies  >111 publications with TIMP2 and Vascular
 Muscle Antibodies  >56 publications with TIMP2 and Muscle
 Bone Antibodies  >54 publications with TIMP2 and Bone
 Embryonic Tissue Antibodies  >54 publications with TIMP2 and Embryonic Tissue
 Kidney Antibodies  >52 publications with TIMP2 and Kidney
 Lung Antibodies  >51 publications with TIMP2 and Lung
 Heart Antibodies  >47 publications with TIMP2 and Heart
 Brain Antibodies  >33 publications with TIMP2 and Brain
 Placenta Antibodies  >32 publications with TIMP2 and Placenta
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