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TIMP-4 recombinant protein :: Metalloproteinase inhibitor 4 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1309121
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $590 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $795 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $875 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $895 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,125 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,135 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,235 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,630 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,725 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,175 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Metalloproteinase inhibitor 4 (TIMP-4), Recombinant Protein

 Also Known As   

Recombinant Human Metalloproteinase inhibitor 4

 Product Synonym Names    Tissue inhibitor of metalloproteinases 4; TIMP-4
 Product Gene Name   

TIMP-4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    30-224aa; Full length
 Sequence    CSCAPAHPQQ HICHSALVIR AKISSEKVVP ASADPADTEK MLRYEIKQIK MFKGFEKVKD VQYIYTPFDS SLCGVKLEAN SQKQYLLTGQ VLSDGKVFIH LCNYIEPWED LSLVQRESLN HHYHLNCGCQ ITTCYTVPCT ISAPNECLWT DWLLERKLYG YQAQHYVCMK HVDGTCSWYR GHLPLRKEFV DIVQP
 OMIM    601915
 3D Structure    ModBase 3D Structure for Q99727
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of TIMP-4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for TIMP-4 recombinant protein

   Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
 Product Categories/Family for TIMP-4 recombinant protein    Cancer
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 SDS-PAGE of TIMP-4 recombinant protein    TIMP-4 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for TIMP-4. It may not necessarily be applicable to this product.
 NCBI GI #    4507515
 NCBI GeneID    7079
 NCBI Accession #    NP_003247.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003256.3 [Other Products]
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 UniProt Primary Accession #    Q99727 [Other Products]
 UniProt Secondary Accession #    B2R7K6 [Other Products]
 UniProt Related Accession #    Q99727 [Other Products]
 Molecular Weight    24.4kD
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 NCBI Official Full Name    metalloproteinase inhibitor 4
 NCBI Official Synonym Full Names    TIMP metallopeptidase inhibitor 4
 NCBI Official Symbol    TIMP4 [Similar Products]
 NCBI Protein Information    metalloproteinase inhibitor 4
 UniProt Protein Name    Metalloproteinase inhibitor 4
 UniProt Synonym Protein Names   
Tissue inhibitor of metalloproteinases 4; TIMP-4
 Protein Family    Metalloproteinase inhibitor
 UniProt Gene Name    TIMP4 [Similar Products]
 UniProt Synonym Gene Names    TIMP-4 [Similar Products]
 UniProt Entry Name    TIMP4_HUMAN
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 NCBI Summary for TIMP-4    This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TIMP-4    TIMP4: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9. Belongs to the protease inhibitor I35 (TIMP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p25

Cellular Component: extracellular space; proteinaceous extracellular matrix; sarcomere

Molecular Function: metal ion binding; metalloendopeptidase inhibitor activity; protease binding

Biological Process: central nervous system development; negative regulation of membrane protein ectodomain proteolysis; negative regulation of metalloenzyme activity; Notch signaling pathway; ovulation cycle; response to cytokine stimulus; response to drug; response to lipopolysaccharide; response to organic substance; response to peptide hormone stimulus
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Product References and Citations for TIMP-4 recombinant protein

   Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4.Greene J., Wang M., Liu Y.E., Raymond L.A., Rosen C., Shi Y.E.J. Biol. Chem. 271:30375-30380(1996)
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 Research Articles on TIMP-4    1. Upregulation of plasma TIMP-4 might contribute to PIH [pregnancy-induced hypertension] processes
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with TIMP-4 recombinant proteinPathways associated with TIMP-4 recombinant protein
 Reference Product  PubMed Publications
 MMP2 recombinant protein  >25 publications with TIMP-4 and MMP2
 MMP9 recombinant protein  >22 publications with TIMP-4 and MMP9
 MMP3 recombinant protein  >13 publications with TIMP-4 and MMP3
 MMP13 recombinant protein  >11 publications with TIMP-4 and MMP13
 MMP8 recombinant protein  >6 publications with TIMP-4 and MMP8
 MMP14 recombinant protein  >6 publications with TIMP-4 and MMP14
 MMP7 recombinant protein  >5 publications with TIMP-4 and MMP7
 MMP26 recombinant protein  >1 publications with TIMP-4 and MMP26
 Products by Pathway  Pathway Diagram
 Matrix Metalloproteinases Pathway antibodies  Matrix Metalloproteinases Pathway Diagram
Diseases associated with TIMP-4 recombinant proteinOrgans/Tissues associated with TIMP-4 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >21 publications with TIMP-4 and Cardiovascular Diseases
 Inflammation Antibodies  >14 publications with TIMP-4 and Inflammation
 Fibrosis Antibodies  >9 publications with TIMP-4 and Fibrosis
 Nervous System Diseases Antibodies  >9 publications with TIMP-4 and Nervous System Diseases
 Disease Models, Animal Antibodies  >8 publications with TIMP-4 and Disease Models, Animal
 Myocardial Infarction Antibodies  >7 publications with TIMP-4 and Myocardial Infarction
 Necrosis Antibodies  >6 publications with TIMP-4 and Necrosis
 Atherosclerosis Antibodies  >5 publications with TIMP-4 and Atherosclerosis
 Hypertrophy Antibodies  >5 publications with TIMP-4 and Hypertrophy
 Lung Neoplasms Antibodies  >4 publications with TIMP-4 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >18 publications with TIMP-4 and Heart
 Vascular Antibodies  >14 publications with TIMP-4 and Vascular
 Lung Antibodies  >11 publications with TIMP-4 and Lung
 Brain Antibodies  >8 publications with TIMP-4 and Brain
 Embryonic Tissue Antibodies  >7 publications with TIMP-4 and Embryonic Tissue
 Bone Antibodies  >5 publications with TIMP-4 and Bone
 Connective Tissue Antibodies  >5 publications with TIMP-4 and Connective Tissue
 Eye Antibodies  >3 publications with TIMP-4 and Eye
 Skin Antibodies  >2 publications with TIMP-4 and Skin
 Liver Antibodies  >2 publications with TIMP-4 and Liver
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