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STEAP1 recombinant protein :: Metalloreductase STEAP1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS969772
SDS-PAGE
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.05 mg  /  $190 +1 FREE 8GB USB
0.1 mg  /  $285 +1 FREE 8GB USB
0.2 mg  /  $460 +1 FREE 8GB USB
0.5 mg  /  $750 +1 FREE 8GB USB
1 mg  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Metalloreductase STEAP1, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Metalloreductase STEAP1

 Product Synonym Names    Six-transmembrane epithelial antigen of prostate 1
 Product Gene Name   

STEAP1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PRSS24; STEAP [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    3-69aa; Partial
 Sequence    SRKDITNQEE LWKMKPRRNL EEDDYLHKDT GETSMLKRPV LLHLHQTAHA DEFDCPSELQ HTQELFP
 OMIM    604415
 3D Structure    ModBase 3D Structure for Q9UHE8
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of STEAP1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for STEAP1 recombinant protein

   Metalloreductase that has the ability to reduce both Fe3+ to Fe2+ and Cu2+ to Cu1+. Uses NAD+ as acceptor.
 Product Categories/Family for STEAP1 recombinant protein    Transport
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 SDS-PAGE of STEAP1 recombinant protein    STEAP1 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for STEAP1. It may not necessarily be applicable to this product.
 NCBI GI #    9558759
 NCBI GeneID    26872
 NCBI Accession #    NP_036581.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012449.2 [Other Products]
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 UniProt Primary Accession #    Q9UHE8 [Other Products]
 UniProt Secondary Accession #    O95034; A4D1E0 [Other Products]
 UniProt Related Accession #    Q9UHE8 [Other Products]
 Molecular Weight    35.4kD
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 NCBI Official Full Name    metalloreductase STEAP1
 NCBI Official Synonym Full Names    six transmembrane epithelial antigen of the prostate 1
 NCBI Official Symbol    STEAP1 [Similar Products]
 NCBI Official Synonym Symbols   
STEAP; PRSS24
[Similar Products]
 NCBI Protein Information    metalloreductase STEAP1
 UniProt Protein Name    Metalloreductase STEAP1
 UniProt Synonym Protein Names   
Six-transmembrane epithelial antigen of prostate 1
 Protein Family    Metalloreductase
 UniProt Gene Name    STEAP1 [Similar Products]
 UniProt Synonym Gene Names    PRSS24; STEAP [Similar Products]
 UniProt Entry Name    STEA1_HUMAN
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 NCBI Summary for STEAP1    This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
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 UniProt Comments for STEAP1    STEAP1: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family.

Protein type: Oxidoreductase; EC 1.16.1.-; Membrane protein, multi-pass; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 7q21

Cellular Component: endosome membrane; integral to plasma membrane; intercellular junction; membrane; plasma membrane

Molecular Function: channel activity; cupric reductase activity; metal ion binding; transporter activity

Biological Process: copper ion import; iron ion homeostasis; transmembrane transport
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Product References and Citations for STEAP1 recombinant protein

   STEAP a prostate-specific cell-surface antigen highly expressed in human prostate tumors.Hubert R.S., Vivanco I., Chen E., Rastegar S., Leong K., Mitchell S.C., Madraswala R., Zhou Y., Kuo J., Raitano A.B., Jakobovits A., Saffran D.C., Afar D.E.H.Proc. Natl. Acad. Sci. U.S.A. 96:14523-14528(1999) The DNA sequence of human chromosome 7.Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.Nature 424:157-164(2003) Human chromosome 7 DNA sequence and biology.Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.Science 300:767-772(2003) The Steap proteins are metalloreductases.Ohgami R.S., Campagna D.R., McDonald A., Fleming M.D.Blood 108:1388-1394(2006)
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 Research Articles on STEAP1    1. These findings highlight the ability of immuno-PET with (89)Zr-2109A to detect acute changes in STEAP1 expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with STEAP1 recombinant proteinPathways associated with STEAP1 recombinant protein
 Reference Product  PubMed Publications
 PSCA recombinant protein  >3 publications with STEAP1 and PSCA
 Products by Pathway  Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
 Mineral Absorption Pathway antibodies  Mineral Absorption Pathway Diagram
Diseases associated with STEAP1 recombinant proteinOrgans/Tissues associated with STEAP1 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >6 publications with STEAP1 and Lung Neoplasms
 Lung Diseases Antibodies  >5 publications with STEAP1 and Lung Diseases
 Neoplasms, Experimental Antibodies  >4 publications with STEAP1 and Neoplasms, Experimental
 Hyperplasia Antibodies  >4 publications with STEAP1 and Hyperplasia
 Ovarian Neoplasms Antibodies  >3 publications with STEAP1 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >1 publications with STEAP1 and Disease Models, Animal
 Kidney Diseases Antibodies  >1 publications with STEAP1 and Kidney Diseases
 Inflammation Antibodies  >1 publications with STEAP1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >40 publications with STEAP1 and Prostate
 Bone Antibodies  >9 publications with STEAP1 and Bone
 Lung Antibodies  >6 publications with STEAP1 and Lung
 Testis Antibodies  >2 publications with STEAP1 and Testis
 Pancreas Antibodies  >2 publications with STEAP1 and Pancreas
 Liver Antibodies  >1 publications with STEAP1 and Liver
 Brain Antibodies  >1 publications with STEAP1 and Brain
 Mammary Gland Antibodies  >1 publications with STEAP1 and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with STEAP1 and Embryonic Tissue
 Ovary Antibodies  >1 publications with STEAP1 and Ovary
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