NP_000420.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
S-adenosylmethionine synthase isoform type-1
NCBI Official Synonym Full Names
methionine adenosyltransferase I, alpha
NCBI Protein Information
S-adenosylmethionine synthase isoform type-1; MAT 1; MAT-I/III; S-adenosylmethionine synthetase isoform type-1; adoMet synthase 1; adoMet synthetase 1; methionine adenosyltransferase 1; methionine adenosyltransferase I/III
UniProt Protein Name
S-adenosylmethionine synthase isoform type-1
UniProt Synonym Protein Names
Methionine adenosyltransferase 1; MAT 1; Methionine adenosyltransferase I/III; MAT-I/III
UniProt Synonym Gene Names
UniProt Entry Name
METK1_HUMAN
NCBI Summary for MAT1A
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for MAT1A
MAT1A: Catalyzes the formation of S-adenosylmethionine from methionine and ATP. Defects in MAT1A are the cause of methionine adenosyltransferase deficiency (MATD); also called MAT I/III deficiency. MATD is an inborn error of metabolism resulting in isolated hypermethioninemia. Most patients have no clinical abnormalities, although some neurologic symptoms may be present in rare cases with severe loss of methionine adenosyltransferase activity. Belongs to the AdoMet synthase family.
Protein type: Transferase; Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: cytosol
Molecular Function: methionine adenosyltransferase activity; metal ion binding; ATP binding
Biological Process: methylation; amino acid metabolic process; sulfur amino acid metabolic process; xenobiotic metabolic process; S-adenosylmethionine biosynthetic process; one-carbon compound metabolic process
Disease: Methionine Adenosyltransferase Deficiency
Research Articles on MAT1A
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Products associated with MAT1A recombinant protein
Pathways associated with MAT1A recombinant protein
Diseases associated with MAT1A recombinant protein
Organs/Tissues associated with MAT1A recombinant protein
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