Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow NR3C2  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Calcitonin Gene Related Peptide (CGRP) ELISA Kit
 • Sirtuin 3 (Sirt3) Antibody
 • X-Linked Inhibitor Of Apoptosis (XIAP) Recombinant Protein
 • DEP domain containing 6 (DEPDC6) ELISA Kit
 • Soluble cluster of differentiation 86 (SCD86) ELISA Kit
 • Cytosolic Phospholipase A2 (CPLA2) ELISA Kit
 • Procalcitonin (PCT) ELISA Kit
 • CNTNAP4 ELISA Kit
 • MFAP4 ELISA Kit
 • TSH ELISA Kit
 • A Disintegrin And Metalloprotease 22 (ADAM22) ELISA Kit
 • CD24 Antibody
 • neurofilament, light polypeptide (NEFL) ELISA Kit
 • AMBP Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

NR3C2 recombinant protein :: Mineralocorticoid receptor (NR3C2), partial Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS965320 NR3C2 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $1,150 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,150 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,380 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,380 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,780 +2 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,780 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,240 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,240 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,275 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mineralocorticoid receptor (NR3C2), partial, Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Mineralocorticoid receptor (NR3C2), partial

 Product Synonym Names    Mineralocorticoid receptor; MR; Nuclear receptor subfamily 3 group C member 2
 Product Gene Name   

NR3C2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    NR3C2; MCR; MLR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence Positions    1-350, Fragment at the N-terminal, provide the fragment of Modulating region.
 Sequence    METKGYHSLP EGLDMERRWG QVSQAVERSS LGPTERTDEN NYMEIVNVSC VSGAIPNNST QGSSKEKQEL LPCLQQDNNR PGILTSDIKT ELESKELSAT VAESMGLYMD SVRDADYSYE QQNQQGSMSP AKIYQNVEQL VKFYKGNGHR PSTLSCVNTP LRSFMSDSGS SVNGGVMRAI VKSPIMCHEK SPSVCSPLNM TSSVCSPAGI NSVSSTTASF GSFPVHSPIT QGTPLTCSPN AENRGSRSHS PAHASNVGSP LSSPLSSMKS SISSPPSHCS VKSPVSSPNN VTLRSSVSSP ANINNSRCSV SSPSNTNNRS TLSSPAASTV GSICSPVNNA FSYTASGTSA
 OMIM    gene 605115
 3D Structure    ModBase 3D Structure for P08235
Section Bar
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
Section Bar
 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
Section Bar
 Species    Homo sapiens (Human)
Section Bar
 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of NR3C2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for NR3C2 recombinant protein

   This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants.
NCBI/Uniprot data below describe general gene information for NR3C2. It may not necessarily be applicable to this product.
 NCBI GI #    158508572
 NCBI GeneID    4306
 NCBI Accession #    NP_000892.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000901.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P08235 [Other Products]
 UniProt Secondary Accession #    Q2NKL1; Q96KQ8; Q96KQ9; B0ZBF5; B0ZBF7 [Other Products]
 UniProt Related Accession #    P08235 [Other Products]
 Molecular Weight    94,359 Da
Table BarTOPTable Bar
 NCBI Official Full Name    mineralocorticoid receptor isoform 1
 NCBI Official Synonym Full Names    nuclear receptor subfamily 3, group C, member 2
 NCBI Official Symbol    NR3C2 [Similar Products]
 NCBI Official Synonym Symbols   
MR; MCR; MLR; NR3C2VIT
[Similar Products]
 NCBI Protein Information    mineralocorticoid receptor; aldosterone receptor; mineralocorticoid receptor 1; mineralocorticoid receptor delta
 UniProt Protein Name    Mineralocorticoid receptor
 UniProt Synonym Protein Names   
Nuclear receptor subfamily 3 group C member 2
 Protein Family    Mineralocorticoid receptor
 UniProt Gene Name    NR3C2 [Similar Products]
 UniProt Synonym Gene Names    MCR; MLR; MR [Similar Products]
 UniProt Entry Name    MCR_HUMAN
Section Bar
 NCBI Summary for NR3C2    This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Section Bar
 UniProt Comments for NR3C2    MCR: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. Defects in NR3C2 are a cause of autosomal dominant pseudohypoaldosteronism type I (AD-PHA1). PHA1 is characterized by urinary salt wasting, resulting from target organ unresponsiveness to mineralocorticoids. There are 2 forms of PHA1: the autosomal dominant form that is mild, and the recessive form which is more severe and due to defects in any of the epithelial sodium channel subunits. In AD-PHA1 the target organ defect is confined to kidney. Clinical expression can vary from asymptomatic to moderate. It may be severe at birth, but symptoms remit with age. Familial and sporadic cases have been reported. Defects in NR3C2 are a cause of early-onset hypertension with severe exacerbation in pregnancy (EOHSEP). Inheritance is autosomal dominant. The disease is characterized by the onset of severe hypertension before the age of 20, and by suppression of aldosterone secretion. Belongs to the nuclear hormone receptor family. NR3 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 4q31.1

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; receptor complex

Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; transcription factor activity; steroid binding

Biological Process: transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-dependent; steroid hormone mediated signaling; gene expression; signal transduction

Disease: Hypertension, Early-onset, Autosomal Dominant, With Severe Exacerbation In Pregnancy; Pseudohypoaldosteronism, Type I, Autosomal Dominant
Table BarTOPTable Bar
 Research Articles on NR3C2    1. results indicate a regulatory influence of MR signaling on human T-cell migration and suggest a role for endogenous aldosterone in the redistribution of T-cell subsets to lymph nodes, involving CD62L, CCR7, and CXCR4.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with NR3C2 recombinant proteinPathways associated with NR3C2 recombinant protein
 Reference Product  PubMed Publications
 CYP11B2 recombinant protein  >124 publications with NR3C2 and CYP11B2
 HSD11B2 recombinant protein  >39 publications with NR3C2 and HSD11B2
 NR3C1 recombinant protein  >15 publications with NR3C2 and NR3C1
 REN recombinant protein  >7 publications with NR3C2 and REN
 FKBP4 recombinant protein  >4 publications with NR3C2 and FKBP4
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
Diseases associated with NR3C2 recombinant proteinOrgans/Tissues associated with NR3C2 recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >766 publications with NR3C2 and Cardiovascular Diseases
 Hypertension Antibodies  >745 publications with NR3C2 and Hypertension
 Vascular Diseases Antibodies  >584 publications with NR3C2 and Vascular Diseases
 Heart Diseases Antibodies  >327 publications with NR3C2 and Heart Diseases
 Heart Failure Antibodies  >272 publications with NR3C2 and Heart Failure
 Kidney Diseases Antibodies  >266 publications with NR3C2 and Kidney Diseases
 Fibrosis Antibodies  >224 publications with NR3C2 and Fibrosis
 Inflammation Antibodies  >149 publications with NR3C2 and Inflammation
 Nervous System Diseases Antibodies  >143 publications with NR3C2 and Nervous System Diseases
 Hypertrophy Antibodies  >138 publications with NR3C2 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1133 publications with NR3C2 and Brain
 Kidney Antibodies  >916 publications with NR3C2 and Kidney
 Vascular Antibodies  >413 publications with NR3C2 and Vascular
 Muscle Antibodies  >367 publications with NR3C2 and Muscle
 Liver Antibodies  >173 publications with NR3C2 and Liver
 Intestine Antibodies  >102 publications with NR3C2 and Intestine
 Lung Antibodies  >65 publications with NR3C2 and Lung
 Thyroid Antibodies  >52 publications with NR3C2 and Thyroid
 Embryonic Tissue Antibodies  >44 publications with NR3C2 and Embryonic Tissue
 Placenta Antibodies  >44 publications with NR3C2 and Placenta
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions