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SLC20A4 recombinant protein :: Mitochondrial 2-oxoglutarate/malate carrier protein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717341
SDS-Page
Unit / Price
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mitochondrial 2-oxoglutarate/malate carrier protein (SLC20A4), Recombinant Protein

 Also Known As   

Recombinant Human Mitochondrial 2-oxoglutarate/malate carrier protein

 Product Synonym Names    Solute carrier family 25 member 11
 Product Gene Name   

SLC20A4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    43-82
 Sequence    DLVKNRMQLS GEGAKTREYK TSFHALTSIL KAEGLRGIYT
 OMIM    604165
 3D Structure    ModBase 3D Structure for Q02978
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SLC20A4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for SLC20A4 recombinant protein

   Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism.
 Product Categories/Family for SLC20A4 recombinant protein    Transport
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 SDS-Page of SLC20A4 recombinant protein    SLC20A4 recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for SLC20A4. It may not necessarily be applicable to this product.
 NCBI GeneID    8402
 NCBI Accession #    NP_003553.2 [Other Products]
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 UniProt Primary Accession #    Q02978 [Other Products]
 UniProt Secondary Accession #    O75537; Q969P7; F5GY65 [Other Products]
 UniProt Related Accession #    Q02978 [Other Products]
 Molecular Weight    31.9kD
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 NCBI Official Synonym Full Names    solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
 NCBI Official Symbol    SLC25A11 [Similar Products]
 NCBI Official Synonym Symbols   
OGC; SLC20A4
[Similar Products]
 NCBI Protein Information    mitochondrial 2-oxoglutarate/malate carrier protein
 UniProt Protein Name    Mitochondrial 2-oxoglutarate/malate carrier protein
 UniProt Synonym Protein Names   
Solute carrier family 25 member 11
 Protein Family    Mitochondrial 2-oxoglutarate/malate carrier protein
 UniProt Gene Name    SLC25A11 [Similar Products]
 UniProt Synonym Gene Names    SLC20A4; OGCP [Similar Products]
 UniProt Entry Name    M2OM_HUMAN
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 NCBI Summary for SLC20A4    The oxoglutarate/malate carrier transports 2-oxoglutarate across the inner membranes of mitochondria in an electroneutral exchange for malate or other dicarboxylic acids (summary by Iacobazzi et al., 1992 [PubMed 1457818]).[supplied by OMIM, Jan 2011]
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 UniProt Comments for SLC20A4    SLC25A11: Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Belongs to the mitochondrial carrier family.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter; Mitochondrial

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: integral to plasma membrane; mitochondrial inner membrane; mitochondrion; nucleus

Molecular Function: oxoglutarate:malate antiporter activity; structural constituent of ribosome

Biological Process: alpha-ketoglutarate transport; carbohydrate metabolic process; gluconeogenesis; glucose metabolic process; translation; transport
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Product References and Citations for SLC20A4 recombinant protein

   Sequences of the human and bovine genes for the mitochondrial 2-oxoglutarate carrier.Iacobazzi V., Palmieri F., Runswick M.J., Walker J.E.DNA Seq. 3:79-88(1992) Yu W., Gibbs R.A. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.Nature 440:1045-1049(2006) Bienvenut W.V.Submitted (JUN-2005) to UniProtKB Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.Anal. Chem. 81:4493-4501(2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.Science 325:834-840(2009) Initial characterization of the human central proteome.Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.BMC Syst. Biol. 5:17-17(2011) Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.J. Proteomics 96:253-262(2014)
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 Research Articles on SLC20A4    1. Compares and contrasts all the known human SLC25A* genes and includes functional information.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with SLC20A4 recombinant proteinPathways associated with SLC20A4 recombinant protein
 Reference Product  PubMed Publications
 MDH2 recombinant protein  >3 publications with SLC20A4 and MDH2
 MDH1 recombinant protein  >1 publications with SLC20A4 and MDH1
 Products by Pathway  Pathway Diagram
 Gluconeogenesis Pathway antibodies  Gluconeogenesis Pathway Diagram
 Glucose Metabolism Pathway antibodies  Glucose Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Carbohydrates Pathway antibodies  Metabolism Of Carbohydrates Pathway Diagram
Diseases associated with SLC20A4 recombinant proteinOrgans/Tissues associated with SLC20A4 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with SLC20A4 and Liver Diseases
 Chromosome Aberrations Antibodies  >1 publications with SLC20A4 and Chromosome Aberrations
 Heart Diseases Antibodies  >1 publications with SLC20A4 and Heart Diseases
 Liver Neoplasms, Experimental Antibodies  >1 publications with SLC20A4 and Liver Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >1 publications with SLC20A4 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with SLC20A4 and Disease Models, Animal
 Liver Neoplasms Antibodies  >1 publications with SLC20A4 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with SLC20A4 and Neoplasms, Experimental
 Liver Cirrhosis Antibodies  >1 publications with SLC20A4 and Liver Cirrhosis
 Hypertrophy Antibodies  >1 publications with SLC20A4 and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >4 publications with SLC20A4 and Kidney
 Liver Antibodies  >3 publications with SLC20A4 and Liver
 Brain Antibodies  >2 publications with SLC20A4 and Brain
 Heart Antibodies  >1 publications with SLC20A4 and Heart
 Blood Antibodies  >1 publications with SLC20A4 and Blood
 Muscle Antibodies  >1 publications with SLC20A4 and Muscle
 Intestine Antibodies  >1 publications with SLC20A4 and Intestine
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