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GPD2 recombinant protein :: Mitochondrial glycerol-3-phosphate dehydrogenase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS635756 GPD2 recombinant protein
Unit / Price
0.01 mg  /  $440 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mitochondrial glycerol-3-phosphate dehydrogenase (GPD2), Recombinant Protein

★Popular Item★
 Also Known As   

Mitochondrial glycerol-3-phosphate dehydrogenase, Recombinant, Human (mGPD)

 Product Gene Name   

GPD2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 2; NC_000002.11 (157291965..157442915). Location: 2q24.1
 OMIM    138430
 3D Structure    ModBase 3D Structure for P43304
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 Host    Human, Recombinant, E Coli
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 Purity/Purification    Highly Purified
Purified. 95% by SDS-PAGE.
 Form/Format    Supplied as a liquid in 20mM Tris HCl, pH 8.0, 1mM EDTA, 50% glycerol.
 Concentration    0.095mg/ml (lot specific)
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of GPD2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for GPD2 recombinant protein

   Recombinant mGPD comprises a 558 amino acid fragment (43-600) corresponding to the GlpA domain fragment of the mature mGPD protein and is expressed in E. coli with an amino-terminal hexahistidine tag.

Mitochondrial glycerol-3-phosphate dehydrogenase (mGPD) is a Ca2+-sensitive, FAD-binding protein, located on the outer surface of the inner mitochondrial membrane. mGPD catalyses the oxidation of glycerol-3-phosphate to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Two isoforms have been described for mGPD. Isoform 1 comprises 727aa residues, whereas isoform 2 lacks 126aa residues of the N- terminus.Deficiency of mGPD appears to contribute to the impairment of glucose-stimulated insulin release in several animal models of non-insulin depend diabetes mellitus.
 Product Categories/Family for GPD2 recombinant protein    Molecular Biology; MB-Enzymes, Dehydrogenase
 Applications Tested/Suitable for GPD2 recombinant protein   

ELISA (EL/EIA)

 Application Notes for GPD2 recombinant protein    Suitable for use in ELISA., , Recommended Dilution:, Optimal dilutions to be determined by the researcher.
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NCBI/Uniprot data below describe general gene information for GPD2. It may not necessarily be applicable to this product.
 NCBI GI #    533693
 NCBI GeneID    2820
 NCBI Accession #    AAA65701.1 [Other Products]
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 UniProt Primary Accession #    P43304 [Other Products]
 UniProt Secondary Accession #    Q59FR1; Q9HAP9; A8K4V0; B3KSA9 [Other Products]
 UniProt Related Accession #    P43304 [Other Products]
 Molecular Weight    66.26kD [Similar Products]
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 NCBI Official Full Name    mitochondrial glycerol-3-phosphate dehydrogenase
 NCBI Official Synonym Full Names    glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
 NCBI Official Symbol    GPD2 [Similar Products]
 NCBI Official Synonym Symbols   
GDH2; GPDM; mGPDH
[Similar Products]
 NCBI Protein Information    glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; mtGPD; GPDH-M; mitochondrial glycerophosphate dehydrogenase
 UniProt Protein Name    Glycerol-3-phosphate dehydrogenase, mitochondrial
 UniProt Synonym Protein Names   
mtGPD
 Protein Family    Glycerol-3-phosphate dehydrogenase
 UniProt Gene Name    GPD2 [Similar Products]
 UniProt Synonym Gene Names    GPD-M; GPDH-M [Similar Products]
 UniProt Entry Name    GPDM_HUMAN
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 NCBI Summary for GPD2    The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]
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 UniProt Comments for GPD2    GPD2: localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2010]

Protein type: EC 1.1.5.3; Lipid Metabolism - glycerophospholipid; Oxidoreductase; Mitochondrial; Calcium-binding

Chromosomal Location of Human Ortholog: 2q24.1

Cellular Component: glycerol-3-phosphate dehydrogenase complex; mitochondrial inner membrane

Molecular Function: glycerol-3-phosphate dehydrogenase activity; calcium ion binding

Biological Process: glycerol-3-phosphate metabolic process; camera-type eye development; multicellular organism growth; cellular lipid metabolic process; gluconeogenesis; glycerol catabolic process

Disease: Diabetes Mellitus, Noninsulin-dependent
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 Research Articles on GPD2    1. Observational study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with GPD2 recombinant proteinPathways associated with GPD2 recombinant protein
 Reference Product  PubMed Publications
 GPD1 recombinant protein  >33 publications with GPD2 and GPD1
 Products by Pathway  Pathway Diagram
 CDP-diacylglycerol Biosynthesis I Pathway antibodies  CDP-diacylglycerol Biosynthesis I Pathway Diagram
 Fatty Acid Beta Oxidation Pathway antibodies  Fatty Acid Beta Oxidation Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Glycerol-3-phosphate Shuttle Pathway antibodies  Glycerol-3-phosphate Shuttle Pathway Diagram
 Glycerol-3-phosphate Shuttle Pathway antibodies  Glycerol-3-phosphate Shuttle Pathway Diagram
 Phosphatidylglycerol Biosynthesis II (non-plastidic) Pathway antibodies  Phosphatidylglycerol Biosynthesis II (non-plastidic) Pathway Diagram
Diseases associated with GPD2 recombinant proteinOrgans/Tissues associated with GPD2 recombinant protein
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >2 publications with GPD2 and Liver Diseases
 Nervous System Diseases Antibodies  >2 publications with GPD2 and Nervous System Diseases
 Fatty Liver Antibodies  >2 publications with GPD2 and Fatty Liver
 Diabetes Mellitus, Type 2 Antibodies  >2 publications with GPD2 and Diabetes Mellitus, Type 2
 Brain Diseases Antibodies  >1 publications with GPD2 and Brain Diseases
 Cholestasis Antibodies  >1 publications with GPD2 and Cholestasis
 Thyroid Diseases Antibodies  >1 publications with GPD2 and Thyroid Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with GPD2 and Carcinoma, Hepatocellular
 Neoplasms Antibodies  >1 publications with GPD2 and Neoplasms
 Weight Loss Antibodies  >1 publications with GPD2 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with GPD2 and Liver
 Blood Antibodies  >4 publications with GPD2 and Blood
 Muscle Antibodies  >3 publications with GPD2 and Muscle
 Connective Tissue Antibodies  >2 publications with GPD2 and Connective Tissue
 Thyroid Antibodies  >2 publications with GPD2 and Thyroid
 Embryonic Tissue Antibodies  >2 publications with GPD2 and Embryonic Tissue
 Brain Antibodies  >2 publications with GPD2 and Brain
 Vascular Antibodies  >1 publications with GPD2 and Vascular
 Placenta Antibodies  >1 publications with GPD2 and Placenta
 Pancreas Antibodies  >1 publications with GPD2 and Pancreas
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