NP_001269712.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
19,154 Da
NCBI Official Full Name
mitochondrial tRNA-specific 2-thiouridylase 1 isoform e
NCBI Official Synonym Full Names
tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
NCBI Protein Information
mitochondrial tRNA-specific 2-thiouridylase 1
UniProt Protein Name
Mitochondrial tRNA-specific 2-thiouridylase 1
UniProt Synonym Protein Names
MTO2 homolog
UniProt Synonym Gene Names
NCBI Summary for TRMU
This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Comments for TRMU
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
Research Articles on TRMU
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Products associated with TRMU recombinant protein
Pathways associated with TRMU recombinant protein
Diseases associated with TRMU recombinant protein
Organs/Tissues associated with TRMU recombinant protein
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