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MAPK13 recombinant protein :: Mitogen-activated protein kinase 13 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1056641
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $890 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,020 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,195 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,270 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,295 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,350 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,865 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,920 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,055 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,475 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mitogen-activated protein kinase 13 (MAPK13), Recombinant Protein

 Also Known As   

Recombinant Human Mitogen-activated protein kinase 13

 Product Synonym Names    Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta; Stress-activated protein kinase 4
 Product Gene Name   

MAPK13 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-365aa; Full Length
 Sequence    MSLIRKKGFY KQDVNKTAWE LPKTYVSPTH VGSGAYGSVC SAIDKRSGEK VAIKKLSRPF QSEIFAKRAY RELLLLKHMQ HENVIGLLDV FTPASSLRNF YDFYLVMPFM QTDLQKIMGM EFSEEKIQYL VYQMLKGLKY IHSAGVVHRD LKPGNLAVNE DCELKILDFG LARHADAEMT GYVVTRWYRA PEVILSWMHY NQTVDIWSVG CIMAEMLTGK TLFKGKDYLD QLTQILKVTG VPGTEFVQKL NDKAAKSYIQ SLPQTPRKDF TQLFPRASPQ AADLLEKMLE LDVDKRLTAA QALTHPFFEP FRDPEEETEA QQPFDDSLEH EKLTVDEWKQ HIYKEIVNFS PIARKDSRRR SGMKL
 OMIM    602899
 3D Structure    ModBase 3D Structure for O15264
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MAPK13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MAPK13 recombinant protein

   Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells
 Product Categories/Family for MAPK13 recombinant protein    Cell Biology
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 SDS-PAGE of MAPK13 recombinant protein    MAPK13 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for MAPK13. It may not necessarily be applicable to this product.
 NCBI GI #    4506085
 NCBI GeneID    5603
 NCBI Accession #    NP_002745.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002754.4 [Other Products]
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 UniProt Primary Accession #    O15264 [Other Products]
 UniProt Secondary Accession #    O14739; O15124; Q5U4A5; Q6FI46; Q9UNU0 [Other Products]
 UniProt Related Accession #    O15264 [Other Products]
 Molecular Weight    58.06kD
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 NCBI Official Full Name    mitogen-activated protein kinase 13
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 13
 NCBI Official Symbol    MAPK13 [Similar Products]
 NCBI Official Synonym Symbols   
SAPK4; PRKM13; MAPK 13; MAPK-13; p38delta
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 13
 UniProt Protein Name    Mitogen-activated protein kinase 13
 UniProt Synonym Protein Names   
Mitogen-activated protein kinase p38 delta; MAP kinase p38 delta; Stress-activated protein kinase 4
 Protein Family    Mitogen-activated protein kinase
 UniProt Gene Name    MAPK13 [Similar Products]
 UniProt Synonym Gene Names    PRKM13; SAPK4; MAP kinase 13; MAPK 13; MAP kinase p38 delta [Similar Products]
 UniProt Entry Name    MK13_HUMAN
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 NCBI Summary for MAPK13    This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
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 UniProt Comments for MAPK13    P38D: a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have a few hundred substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of tau and STH. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator Myb in response to stress which leads to rapid Myb degradation via a proteasome-dependent pathway. Phosphorylates and down-regulates PKD1 during regulation of insulin secretion in pancreatic beta cells. Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells. This description may include information from UniProtKB

Protein type: Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.24; CMGC group; MAPK family; MAPK/p38 subfamily; p38 subfamily

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: cytosol

Molecular Function: ATP binding; MAP kinase activity; protein binding; protein serine/threonine kinase activity

Biological Process: cell cycle; MAPKKK cascade; nerve growth factor receptor signaling pathway; peptidyl-serine phosphorylation; positive regulation of inflammatory response; positive regulation of interleukin-6 production; Ras protein signal transduction; regulation of transcription, DNA-dependent; response to osmotic stress; response to stress; transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway
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Product References and Citations for MAPK13 recombinant protein

   Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6)
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 Research Articles on MAPK13    1. MAPK13 undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MAPK13 recombinant proteinPathways associated with MAPK13 recombinant protein
 Reference Product  PubMed Publications
 JUN recombinant protein  >2 publications with MAPK13 and JUN
 MAP2K6 recombinant protein  >1 publications with MAPK13 and MAP2K6
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 DSCAM Interactions Pathway antibodies  DSCAM Interactions Pathway Diagram
Diseases associated with MAPK13 recombinant proteinOrgans/Tissues associated with MAPK13 recombinant protein
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >6 publications with MAPK13 and Skin Diseases
 Lung Diseases Antibodies  >3 publications with MAPK13 and Lung Diseases
 Breast Neoplasms Antibodies  >3 publications with MAPK13 and Breast Neoplasms
 Brain Diseases Antibodies  >3 publications with MAPK13 and Brain Diseases
 Inflammation Antibodies  >2 publications with MAPK13 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >1 publications with MAPK13 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with MAPK13 and Liver Neoplasms
 Hypertension Antibodies  >1 publications with MAPK13 and Hypertension
 Fibrosis Antibodies  >1 publications with MAPK13 and Fibrosis
 Lung Neoplasms Antibodies  >1 publications with MAPK13 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with MAPK13 and Brain
 Muscle Antibodies  >3 publications with MAPK13 and Muscle
 Liver Antibodies  >3 publications with MAPK13 and Liver
 Lung Antibodies  >3 publications with MAPK13 and Lung
 Skin Antibodies  >2 publications with MAPK13 and Skin
 Blood Antibodies  >2 publications with MAPK13 and Blood
 Kidney Antibodies  >2 publications with MAPK13 and Kidney
 Eye Antibodies  >1 publications with MAPK13 and Eye
 Heart Antibodies  >1 publications with MAPK13 and Heart
 Prostate Antibodies  >1 publications with MAPK13 and Prostate
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