NP_496331.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
140,342 Da
NCBI Official Full Name
Mitotic chromosome and X-chromosome-associated protein mix-1
NCBI Protein Information
Mitotic chromosome and X-chromosome-associated protein mix-1
UniProt Protein Name
Mitotic chromosome and X-chromosome-associated protein mix-1
UniProt Synonym Protein Names
Lethal protein 29; Structural maintenance of chromosomes protein 2
UniProt Synonym Gene Names
UniProt Comments for mix-1
Essential protein required for both chromosome condensation and segregation and X-chromosome dosage compensation depending on its binding partners (PubMed:9458050, PubMed:11914278, PubMed:19119011, PubMed:18198337, PubMed:19781752). Central component of the condensin I complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes (PubMed:11914278, PubMed:18198337, PubMed:19119011). The condensin complex introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases (PubMed:11914278). Converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (). Central component of the condensin II complex, a complex that seems to play a role in prophase chromosome condensation and organization (PubMed:19119011, PubMed:15557118). Both the condensin complex I and II play a role in meiotic and mitotic chromosome segregation (PubMed:11914278, PubMed:19119011, PubMed:15557118). Plays a role in robust cytokinesis upon the presence of chromatin obstructions (PubMed:23684975). Also a member of the condensin I-like dosage compensation complex that associates specifically with hermaphrodite X chromosomes to reduce their gene transcription during interphase (PubMed:9458050, PubMed:19119011, PubMed:18198337, PubMed:19781752).
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Products associated with mix-1 recombinant protein
Pathways associated with mix-1 recombinant protein
Organs/Tissues associated with mix-1 recombinant protein
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