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rMCP 1 recombinant protein :: Monocyte Chemotactic Protein-1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142024 rMCP 1 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Monocyte Chemotactic Protein-1 (rMCP 1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Rat Monocyte Chemotactic Protein-1 (CCL2)

 Product Synonym Names    MCP 1 Rat; Monocyte Chemotactic Protein-1 Rat Recombinant (CCL2); Small inducible cytokine A2; CCL2; Monocyte chemotactic protein 1; MCP-1; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte secretory protein JE; HC11; chemokine (C-C motif) ligand 2; MCP1; SCYA2; GDCF-2; SMC-CF; HSMCR30; MGC9434; GDCF-2 HC11; Immediate-early serum-responsive JE protein
 Product Gene Name   

rMCP 1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    QPDAVNAPLT CCYSFTGKMI PMSRLENYKR ITSSRCPKEA VVFVTKLKRE ICADPNKEWV QKYIRKLDQN QVRSETTVFY KIASTLRTSA PLNVNLTHKS EANASTLFST TTSSTSVEVT SMTEN
 3D Structure    ModBase 3D Structure for P14844
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 Host    E Coli
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 Purity/Purification    Greater than 98.0% as determined by SDS-PAGE.
 Form/Format    The protein was lyophilized from a concentrated (1mg/ml) sterile solution containing no additives.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-1 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    ED50 =1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg. The biological activity was determined by measuring the dose dependent chemotaxis with human THP-1 cells. The optimal concentration should be determined for each specific application by an initial dose-response assay.
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 Preparation and Storage    Lyophilized MCP-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of rMCP 1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for rMCP 1 recombinant protein

   Description: Monocyte Chemotactic Protein-1 Rat Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 125 amino acids and having a molecular mass of 14.1 kDa. The MCP-1 is purified by proprietary chromatographic techniques.

Introduction: Chemokine (C-C motif) ligand 2 (CCL2) is a small cytokine belonging to the CC chemokine family that is also known as monocyte chemotactic protein-1 (MCP-1). It is found at the site of tooth eruption and bone degradation. In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and is under the control of nuclear factor ?B (NF?B). CCL2 recruits immune cells, such as monocytes, to sites of tissue injury and infection. This chemokine is produced as a protein precursor containing signal peptide of 23 amino acids and a mature peptide of 76 amino acids. It is a monomeric polypeptide, with a molecular weightof approximately 13kDa. As with many other CC chemokines, CCL2 is located on chromosome 17 in humans. The cell surface receptors that bind CCL2 are CCR2 and CCR5.
 Product Categories/Family for rMCP 1 recombinant protein    CHEMOKINES; Chemokines; MCP
NCBI/Uniprot data below describe general gene information for rMCP 1. It may not necessarily be applicable to this product.
 NCBI GI #    13928714
 NCBI GeneID    24770
 NCBI Accession #    NP_113718.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_031530.1 [Other Products]
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 UniProt Primary Accession #    P14844 [Other Products]
 UniProt Secondary Accession #    Q549R5 [Other Products]
 UniProt Related Accession #    P14844 [Other Products]
 Molecular Weight    16,460 Da
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 NCBI Official Full Name    C-C motif chemokine 2
 NCBI Official Synonym Full Names    chemokine (C-C motif) ligand 2
 NCBI Official Symbol    Ccl2 [Similar Products]
 NCBI Official Synonym Symbols   
MCP-1; Scya2; Sigje
[Similar Products]
 NCBI Protein Information    C-C motif chemokine 2; immediate-early serum-responsive JE protein; immediate-early serum-responsive protein JE; monocyte chemoattractant protein 1; monocyte chemoattractant protein-1; monocyte chemotactic protein 1; small inducible cytokine A2; small inducible gene JE; small-inducible cytokine A2
 UniProt Protein Name    C-C motif chemokine 2
 UniProt Synonym Protein Names   
Immediate-early serum-responsive protein JE; Monocyte chemoattractant protein 1; Monocyte chemotactic protein 1; MCP-1; Small-inducible cytokine A2
 UniProt Gene Name    Ccl2 [Similar Products]
 UniProt Synonym Gene Names    Je; Mcp1; Scya2; MCP-1 [Similar Products]
 UniProt Entry Name    CCL2_RAT
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 NCBI Summary for rMCP 1    a monocyte chemoattractant protein [RGD, Feb 2006]
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 UniProt Comments for rMCP 1    CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Secreted; Chemokine; Motility/polarity/chemotaxis

Cellular Component: extracellular space; cell soma; rough endoplasmic reticulum; perinuclear region of cytoplasm; endocytic vesicle; dendrite; cytoplasm; extracellular region; perikaryon; synapse; nerve terminal

Molecular Function: heparin binding; G-protein-coupled receptor binding; CCR2 chemokine receptor binding; chemokine activity

Biological Process: positive regulation of cell adhesion; maternal process involved in pregnancy; positive regulation of leukocyte migration; response to glucocorticoid stimulus; response to lipopolysaccharide; response to antibiotic; monocyte chemotaxis; regulation of cell shape; response to vitamin B3; transforming growth factor beta receptor signaling pathway; negative regulation of neuron apoptosis; response to drug; neutrophil chemotaxis; organ regeneration; response to amino acid stimulus; positive regulation of tumor necrosis factor production; response to ethanol; response to bacterium; cellular response to insulin stimulus; response to heat; response to mechanical stimulus; positive regulation of endothelial cell proliferation; response to activity; response to progesterone stimulus; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of collagen biosynthetic process; chemokinesis; positive regulation of synaptic transmission; positive regulation of cellular extravasation; positive regulation of cell-cell adhesion; response to wounding; lipopolysaccharide-mediated signaling pathway; protein kinase B signaling cascade; response to gamma radiation; inflammatory response; lymphocyte chemotaxis; aging; cytokine and chemokine mediated signaling pathway; MAPKKK cascade; cytoskeleton organization and biogenesis; glial cell migration; macrophage chemotaxis; leukocyte migration during inflammatory response; cellular calcium ion homeostasis; negative regulation of angiogenesis; positive regulation of leukocyte mediated cytotoxicity; maternal process involved in parturition; response to hypoxia; positive regulation of T cell activation; vascular endothelial growth factor receptor signaling pathway; astrocyte cell migration
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 Research Articles on rMCP 1    1. PKC-NF-kappaB are involved in CCL2-induced elevation of Nav1.8 current density by promoting the phosphorylation of Nav1.8 and its expression.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with rMCP 1 recombinant proteinPathways associated with rMCP 1 recombinant protein
 Reference Product  PubMed Publications
 Tnf recombinant protein  >1992 publications with rMCP 1 and Tnf
 Ccr2 recombinant protein  >1243 publications with rMCP 1 and Ccr2
 Ccl3 recombinant protein  >902 publications with rMCP 1 and Ccl3
 Icam1 recombinant protein  >692 publications with rMCP 1 and Icam1
 Ccr5 recombinant protein  >333 publications with rMCP 1 and Ccr5
 Il6 recombinant protein  >279 publications with rMCP 1 and Il6
 Ccl7 recombinant protein  >260 publications with rMCP 1 and Ccl7
 Ccr1 recombinant protein  >179 publications with rMCP 1 and Ccr1
 Cx3cr1 recombinant protein  >121 publications with rMCP 1 and Cx3cr1
 Il1b recombinant protein  >60 publications with rMCP 1 and Il1b
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 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
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 Disease Pathway antibodies  Disease Pathway Diagram
Diseases associated with rMCP 1 recombinant proteinOrgans/Tissues associated with rMCP 1 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4450 publications with rMCP 1 and Inflammation
 Necrosis Antibodies  >2591 publications with rMCP 1 and Necrosis
 Cardiovascular Diseases Antibodies  >1868 publications with rMCP 1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1043 publications with rMCP 1 and Atherosclerosis
 Myocardial Ischemia Antibodies  >401 publications with rMCP 1 and Myocardial Ischemia
 Liver Diseases Antibodies  >360 publications with rMCP 1 and Liver Diseases
 Hypersensitivity Antibodies  >327 publications with rMCP 1 and Hypersensitivity
 Glomerulonephritis Antibodies  >289 publications with rMCP 1 and Glomerulonephritis
 Lung Injury Antibodies  >249 publications with rMCP 1 and Lung Injury
 Asthma Antibodies  >211 publications with rMCP 1 and Asthma
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >1097 publications with rMCP 1 and Lung
 Liver Antibodies  >686 publications with rMCP 1 and Liver
 Heart Antibodies  >663 publications with rMCP 1 and Heart
 Connective Tissue Antibodies  >437 publications with rMCP 1 and Connective Tissue
 Prostate Antibodies  >97 publications with rMCP 1 and Prostate
 Dorsal Root Ganglion Antibodies  >56 publications with rMCP 1 and Dorsal Root Ganglion
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