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BMPR1A recombinant protein :: Morphogenetic protein Receptor-1A Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS142257 BMPR1A recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,900 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Morphogenetic protein Receptor-1A (BMPR1A), Recombinant Protein

 Also Known As   

Recombinant Human Bone Morphogenetic protein Receptor-1A

 Product Synonym Names    BMPR1A Human; Bone Morphogenetic Protein Receptor Type IA Human Recombinant; BMPR-1A; BMP-R1A; BMPR1A; BMR1A; CD292; CD-292; Serine/threonine-protein kinase receptor R5; SKR5; Activin receptor-like kinase 3; ALK-3; ACVRLK3; EC 2.7.11.30; CD292 antigen
 Product Gene Name   

BMPR1A recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    174900
 3D Structure    ModBase 3D Structure for P36894
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 Host    Insect Cells
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 Purity/Purification    Greater than 90.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
 Form/Format    CD292 was lyophilized from a concentrated (1mg/ml) sterile solution containing 1X PBS.
Sterile Filtered White lyophilized (freeze-dried) powder.
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 Solubility    It is recommended to reconstitute the lyophilized ALK-3 in sterile PBS not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
 Biological Activity    Measured by its ability to inhibit recombinant human BMP-2 induced alkaline phosphatase production by C2C12 myogenic cells. The ED50 for this effect is typically 1-3 ug/ml in the presence of 500 ng/ml of recombinant human BMP-2 corresponding to a Specific Activity of 2,000 units/mg.
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 Other Notes    Small volumes of BMPR1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for BMPR1A recombinant protein

   Description: BMPR1A Human Recombinant extracellular domain produced in baculovirus is a monomeric, glycosylated, Polypeptide chain fused with 6xHis tag at C-terminus and having a molecular mass of 23 kDa. The BMR1A is purified by proprietary chromatographic techniques.

Introduction: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
 Product Categories/Family for BMPR1A recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines; Bone Morphogenetic Protein
NCBI/Uniprot data below describe general gene information for BMPR1A. It may not necessarily be applicable to this product.
 NCBI GI #    41349437
 NCBI GeneID    657
 NCBI Accession #    NP_004320.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004329.2 [Other Products]
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 UniProt Primary Accession #    P36894 [Other Products]
 UniProt Secondary Accession #    Q8NEN8; A8K6U9 [Other Products]
 UniProt Related Accession #    P36894 [Other Products]
 Molecular Weight    60,198 Da
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 NCBI Official Full Name    bone morphogenetic protein receptor type-1A
 NCBI Official Synonym Full Names    bone morphogenetic protein receptor, type IA
 NCBI Official Symbol    BMPR1A [Similar Products]
 NCBI Official Synonym Symbols   
ALK3; SKR5; CD292; ACVRLK3; 10q23del
[Similar Products]
 NCBI Protein Information    bone morphogenetic protein receptor type-1A; ALK-3; BMP type-1A receptor; BMPR-1A; activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; serine/threonine-protein kinase receptor R5
 UniProt Protein Name    Bone morphogenetic protein receptor type-1A
 UniProt Synonym Protein Names   
Activin receptor-like kinase 3; ALK-3; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292
 Protein Family    Bone morphogenetic protein receptor
 UniProt Gene Name    BMPR1A [Similar Products]
 UniProt Synonym Gene Names    ACVRLK3; ALK3; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5 [Similar Products]
 UniProt Entry Name    BMR1A_HUMAN
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 NCBI Summary for BMPR1A    The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. [provided by RefSeq, Jul 2008]
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 UniProt Comments for BMPR1A    BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: Protein kinase, Ser/Thr (receptor); Membrane protein, integral; Protein kinase, TKL; Kinase, protein; EC 2.7.11.30; TKL group; STKR family; Type1 subfamily

Chromosomal Location of Human Ortholog: 10q22.3

Cellular Component: cell soma; dendrite; integral to membrane; plasma membrane; caveola

Molecular Function: transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; metal ion binding; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: transcription from RNA polymerase II promoter; neural plate mediolateral pattern formation; hindlimb morphogenesis; developmental growth; neural crest cell development; positive regulation of transcription, DNA-dependent; paraxial mesoderm structural organization; mesendoderm development; dorsal/ventral axis specification; palate development; protein amino acid phosphorylation; negative regulation of neurogenesis; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; positive regulation of mesenchymal cell proliferation; ectoderm development; Mullerian duct regression; somitogenesis; in utero embryonic development; stem cell maintenance; lateral mesoderm development; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; mesoderm formation; pituitary gland development; cartilage development; embryonic organ development; immune response; embryonic digit morphogenesis; regulation of lateral mesodermal cell fate specification; positive regulation of epithelial cell proliferation; lung development

Disease: Juvenile Polyposis Syndrome; Polyposis Syndrome, Hereditary Mixed, 2
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 Research Articles on BMPR1A    1. The mRNA/protein expressions of BMPR1alpha was higher in the stenotic colon segment tissue than in the normal colon segment tissue of Hirschsrung disease patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with BMPR1A recombinant proteinPathways associated with BMPR1A recombinant protein
 Reference Product  PubMed Publications
 BMPR2 recombinant protein  >284 publications with BMPR1A and BMPR2
 BMP2 recombinant protein  >180 publications with BMPR1A and BMP2
 BMP4 recombinant protein  >151 publications with BMPR1A and BMP4
 SMAD4 recombinant protein  >103 publications with BMPR1A and SMAD4
 BMP7 recombinant protein  >75 publications with BMPR1A and BMP7
 GDF5 recombinant protein  >41 publications with BMPR1A and GDF5
 BMP6 recombinant protein  >33 publications with BMPR1A and BMP6
 SMAD7 recombinant protein  >13 publications with BMPR1A and SMAD7
 ACVR2B recombinant protein  >8 publications with BMPR1A and ACVR2B
 Products by Pathway  Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signaling Pathway antibodies  BMP Signaling Pathway Diagram
 BMP Signalling And Regulation Pathway antibodies  BMP Signalling And Regulation Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Integrated Breast Cancer Pathway antibodies  Integrated Breast Cancer Pathway Diagram
Diseases associated with BMPR1A recombinant proteinOrgans/Tissues associated with BMPR1A recombinant protein
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >64 publications with BMPR1A and Congenital Abnormalities
 Juvenile polyposis syndrome Antibodies  >45 publications with BMPR1A and Juvenile polyposis syndrome
 Carcinoma Antibodies  >39 publications with BMPR1A and Carcinoma
 Female Urogenital Diseases Antibodies  >19 publications with BMPR1A and Female Urogenital Diseases
 Inflammation Antibodies  >17 publications with BMPR1A and Inflammation
 Hyperplasia Antibodies  >13 publications with BMPR1A and Hyperplasia
 Craniofacial Abnormalities Antibodies  >12 publications with BMPR1A and Craniofacial Abnormalities
 Hamartoma Syndrome, Multiple Antibodies  >11 publications with BMPR1A and Hamartoma Syndrome, Multiple
 Abnormalities, Multiple Antibodies  >11 publications with BMPR1A and Abnormalities, Multiple
 Hypertrophy Antibodies  >9 publications with BMPR1A and Hypertrophy
 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >118 publications with BMPR1A and Embryonic Tissue
 Muscle Antibodies  >78 publications with BMPR1A and Muscle
 Connective Tissue Antibodies  >57 publications with BMPR1A and Connective Tissue
 Brain Antibodies  >54 publications with BMPR1A and Brain
 Heart Antibodies  >54 publications with BMPR1A and Heart
 Vascular Antibodies  >51 publications with BMPR1A and Vascular
 Ovary Antibodies  >50 publications with BMPR1A and Ovary
 Lung Antibodies  >28 publications with BMPR1A and Lung
 Skin Antibodies  >28 publications with BMPR1A and Skin
 Liver Antibodies  >27 publications with BMPR1A and Liver
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