Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow SMAD3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Immunoglobulin A (IgA) ELISA Kit
 • A Disintegrin And Metalloproteinase With Thrombospondin 10 (... Antibody
 • Major allergen Asp f 2 (AFUA_4G09580) Recombinant Protein
 • Apolipoprotein C1 (APOC1) ELISA Kit
 • CBLB Antibody
 • Heat Shock Protein 70 (HSP70) ELISA Kit
 • K protein (K) Recombinant Protein
 • Matrix Metalloproteinase 9 (MMP9) ELISA Kit
 • Goat anti Human IgG Fc Secondary Antibody
 • Butyrophilin subfamily 2 member A2 (BTN2A2) ELISA Kit
 • SIGLEC11 Antibody
 • Interferon gamma Antibody (gamma IFN-AB) ELISA Kit
 • Programmed Cell Death Protein 1 Ligand 1 (PDCD1LG1) ELISA Kit
 • Transcriptional enhancer factor TEF-1 (TEAD1) Recombinant Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

SMAD3 recombinant protein :: Mothers Against Decapentaplegic Homolog 3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143711 SMAD3 recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mothers Against Decapentaplegic Homolog 3 (SMAD3), Recombinant Protein

 Also Known As   

Recombinant Human Mothers Against Decapentaplegic Homolog 3

 Product Synonym Names    SMAD3 Human; Mothers Against Decapentaplegic Homolog 3 Human Recombinant; MADH3; JV15-2; HSPC193; HsT17436; MGC60396; DKFZp586N0721; DKFZp686J10186; SMAD3; Mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; MAD homolog 3; Mad3; hMAD-3; SMAD family member 3; SMAD 3; hSMAD3
 Product Gene Name   

SMAD3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHH HHH SSGLVPRGSH MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP PPGYLSEDGE TSDHQMNHSM DAGSPNLSPN PMSPAHNNLD LQPVTYCEPA FWCSISYYEL NQRVGETFHA SQPSMTVDGF TDPSNSERFC LGLLSNVNRN AAVELTRRHI GRGVRLYYIG GEVFAECLSD SAIFVQSPNC NQRYGWHPAT VCKIPPGCNL KIFNNQEFAA LLAQSVNQGF EAVYQLTRMC TIRMSFVKGW GAEYRRQTVT STPCWIELHL NGPLQWLDKV LTQMGSPSIR CSSVS
 OMIM    114500
 3D Structure    ModBase 3D Structure for P84022
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 90.0% as determined by SDS-PAGE.
 Form/Format    The SMAD3 protein solution contains 20mM Tris-HCl pH-8, 0.1M NaCl, 0.1mM DTT and 20% glycerol.
Sterile Filtered colorless solution.
Section Bar
Section Bar
 Other Notes    Small volumes of SMAD3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for SMAD3 recombinant protein

   Description: SMAD3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 445 amino acids (1-425) and having a molecular mass of 50.2 kDa. SMAD3 is fused to a 20 amino acid His-Tag at N-Terminus and purified by standard chromatography techniques.

Introduction: SMAD3 is part of the SMAD family of proteins that mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 has a role as a transcriptional modulator activated by TGF-Beta and is involved in the regulation of carcinogenesis. SMAD3 mutations are related with the pathogenesis of human osteoarthritis. SMAD3 expression take part in tumor suppression in the premature stages of gastric carcinogenesis. SMAD3 is involved in nuclear translocation of beta-catenin.
 Product Categories/Family for SMAD3 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; SMAD
NCBI/Uniprot data below describe general gene information for SMAD3. It may not necessarily be applicable to this product.
 NCBI GI #    223029440
 NCBI GeneID    4088
 NCBI Accession #    NP_001138574.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145102.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P84022 [Other Products]
 UniProt Secondary Accession #    O09064; O09144; O14510; O35273; Q92940; Q93002; A8K4B6; B7Z4Z5; B7Z6M9; B7Z9Q2; F5H383 [Other Products]
 UniProt Related Accession #    P84022 [Other Products]
 Molecular Weight    25,722 Da
Table BarTOPTable Bar
 NCBI Official Full Name    mothers against decapentaplegic homolog 3 isoform 2
 NCBI Official Synonym Full Names    SMAD family member 3
 NCBI Official Symbol    SMAD3 [Similar Products]
 NCBI Official Synonym Symbols   
LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436
[Similar Products]
 NCBI Protein Information    mothers against decapentaplegic homolog 3; MAD homolog 3; MAD, mothers against decapentaplegic homolog 3; SMA- and MAD-related protein 3; SMAD, mothers against DPP homolog 3; hMAD-3; hSMAD3; mad homolog JV15-2; mad protein homolog; mad3
 UniProt Protein Name    Mothers against decapentaplegic homolog 3
 UniProt Synonym Protein Names   
JV15-2; SMAD family member 3; SMAD 3; Smad3; hSMAD3
 Protein Family    Mothers against decapentaplegic
 UniProt Gene Name    SMAD3 [Similar Products]
 UniProt Synonym Gene Names    MADH3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; SMAD 3; Smad3; hSMAD3 [Similar Products]
 UniProt Entry Name    SMAD3_HUMAN
Section Bar
 NCBI Summary for SMAD3    The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Section Bar
 UniProt Comments for SMAD3    SMAD3: transcription factor phosphorylated and activated by TGF-beta-type receptors. A receptor-regulated Smad (R-smad). Binds directly to consensus DNA-binding elements in the promoters of target genes. In mouse required for establishemnt of the mucosal immune response and proper development of skeleton.

Protein type: Transcription factor; Nuclear receptor co-regulator; DNA-binding

Chromosomal Location of Human Ortholog: 15q22.33

Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nuclear chromatin; plasma membrane; nuclear inner membrane; cytosol; nucleus; receptor complex

Molecular Function: identical protein binding; ubiquitin binding; protein homodimerization activity; zinc ion binding; chromatin DNA binding; beta-catenin binding; transcription factor binding; protein kinase binding; transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity; phosphatase binding; collagen binding; protein binding; sequence-specific DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; bHLH transcription factor binding; transcription factor activity; transforming growth factor beta receptor binding

Biological Process: developmental growth; positive regulation of positive chemotaxis; positive regulation of transcription, DNA-dependent; activin receptor signaling pathway; paraxial mesoderm morphogenesis; embryonic pattern specification; regulation of transforming growth factor beta receptor signaling pathway; transforming growth factor beta receptor signaling pathway; embryonic foregut morphogenesis; positive regulation of stress fiber formation; negative regulation of osteoblast differentiation; negative regulation of mitotic cell cycle; cell cycle arrest; regulation of striated muscle development; pericardium development; somitogenesis; transcription, DNA-dependent; embryonic cranial skeleton morphogenesis; osteoblast development; regulation of transcription from RNA polymerase II promoter; positive regulation of chondrocyte differentiation; mesoderm formation; negative regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein catabolic process; negative regulation of apoptosis; endoderm development; evasion of host defenses by virus; wound healing; T cell activation; negative regulation of transcription from RNA polymerase II promoter; primary microRNA processing; regulation of epithelial cell proliferation; positive regulation of focal adhesion formation; negative regulation of protein amino acid phosphorylation; transport; ureteric bud development; positive regulation of transforming growth factor-beta3 production; thyroid gland development; positive regulation of transcription factor import into nucleus; heart looping; caspase activation; intercellular junction assembly and maintenance; transcription initiation from RNA polymerase II promoter; regulation of immune response; regulation of transforming growth factor-beta2 production; regulation of binding; protein stabilization; in utero embryonic development; liver development; positive regulation of bone mineralization; SMAD protein complex assembly; positive regulation of interleukin-1 beta production; immune system development; negative regulation of inflammatory response; response to hypoxia; immune response; gene expression; negative regulation of cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration

Disease: Loeys-dietz Syndrome 3
Table BarTOPTable Bar
 Research Articles on SMAD3    1. Data indicate that Smad3 protein played a major role in the induction of fibrogenic genes by TGFbeta1 in hepatic stellate cells LX-2.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with SMAD3 recombinant proteinDiseases associated with SMAD3 recombinant protein
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >913 publications with SMAD3 and Fibrosis
 Inflammation Antibodies  >346 publications with SMAD3 and Inflammation
 Disease Models, Animal Antibodies  >333 publications with SMAD3 and Disease Models, Animal
 Liver Diseases Antibodies  >236 publications with SMAD3 and Liver Diseases
 Cardiovascular Diseases Antibodies  >212 publications with SMAD3 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >206 publications with SMAD3 and Kidney Diseases
 Adenocarcinoma Antibodies  >157 publications with SMAD3 and Adenocarcinoma
 Breast Neoplasms Antibodies  >128 publications with SMAD3 and Breast Neoplasms
 Liver Cirrhosis Antibodies  >127 publications with SMAD3 and Liver Cirrhosis
 Necrosis Antibodies  >126 publications with SMAD3 and Necrosis
Organs/Tissues associated with SMAD3 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >599 publications with SMAD3 and Muscle
 Blood Antibodies  >420 publications with SMAD3 and Blood
 Bone Antibodies  >393 publications with SMAD3 and Bone
 Kidney Antibodies  >385 publications with SMAD3 and Kidney
 Lung Antibodies  >377 publications with SMAD3 and Lung
 Liver Antibodies  >357 publications with SMAD3 and Liver
 Vascular Antibodies  >295 publications with SMAD3 and Vascular
 Connective Tissue Antibodies  >293 publications with SMAD3 and Connective Tissue
 Skin Antibodies  >234 publications with SMAD3 and Skin
 Heart Antibodies  >198 publications with SMAD3 and Heart
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions