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MUC1 recombinant protein :: Mucin 1 (MUC1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010839 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $490 +1 FREE 8GB USB
0.5 mg  /  $950 +1 FREE 8GB USB
1 mg  /  $1,400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Mucin 1 (MUC1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mucin 1 (MUC1)

 Product Gene Name   

MUC1 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Mucin 1 (MUC1) (MBS2001934)
Antigen: Mucin 1 (MUC1) (MBS2010839)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.
MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTLEV LFQGPLGSEF - SVV VQLTLAFREG TINVHDVETQ FNQYKTEAAS RYNLTISDVS VSDVPFPFSA QSGAGVPGWG IALLVLVCVL VALAIVYLIA LAVCQCRRKN YGQLDIFPAR DTYHPMSEYP TYHTHGRYVP PSSTDRSPYE KVSAGNGGSS LSYTNPAVAA TSANL
 Chromosome Location    Chromosome: 1; NC_000001.10 (155158300..155162768, complement). Location: 1q21
 OMIM    113720
 3D Structure    ModBase 3D Structure for P15941
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Ser1098~Leu1255 (Accession # P15941) with two N-terminal Tags, His-tag and GST-tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of MUC1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MUC1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for MUC1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of MUC1 recombinant protein    MUC1 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for MUC1. It may not necessarily be applicable to this product.
 NCBI GI #    67189007
 NCBI GeneID    4582
 NCBI Accession #    NP_001018016.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018016.2 [Other Products]
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 UniProt Primary Accession #    P15941 [Other Products]
 UniProt Secondary Accession #    P13931; P15942; P17626; Q0VAP5; A5YRV1; A6ZID9; B1AVQ8; B1AVR0; B6ECA1; E7ESE5; E7EUG9 [Other Products]
 UniProt Related Accession #    P15941 [Other Products]
 Molecular Weight    44kDa
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 NCBI Official Full Name    mucin-1 isoform 2
 NCBI Official Synonym Full Names    mucin 1, cell surface associated
 NCBI Official Symbol    MUC1 [Similar Products]
 NCBI Official Synonym Symbols   
EMA; PEM; PUM; KL-6; MAM6; PEMT; CD227; H23AG; MCKD1; MUC-1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC
[Similar Products]
 NCBI Protein Information    mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-6; mucin 1, transmembrane; tumor-associated mucin; carcinoma-associated mucin; polymorphic epithelial mucin; peanut-reactive urinary mucin; tumor associated epithelial mucin; breast carcinoma-associated antigen DF3; tumor-associated epithelial membrane antigen
 UniProt Protein Name    Mucin-1
 UniProt Synonym Protein Names   
Breast carcinoma-associated antigen DF3; Cancer antigen 15-3; CA 15-3; Carcinoma-associated mucin; Episialin; H23AG; Krebs von den Lungen-6; KL-6; PEMT; Peanut-reactive urinary mucin; PUM; Polymorphic epithelial mucin; PEM; Tumor-associated epithelial membrane antigen; EMA; Tumor-associated mucin; CD_antigen: CD227Cleaved into the following 2 chains:Mucin-1 subunit alpha; MUC1-NT; MUC1-alpha; Mucin-1 subunit beta; MUC1-betaAlternative name(s):MUC1-CT
 Protein Family    Mucin
 UniProt Gene Name    MUC1 [Similar Products]
 UniProt Synonym Gene Names    PUM; MUC-1; CA 15-3; KL-6; PUM; PEM; EMA; MUC1-NT; MUC1-alpha; MUC1-beta [Similar Products]
 UniProt Entry Name    MUC1_HUMAN
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 NCBI Summary for MUC1    This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
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 UniProt Comments for MUC1    MUC1: a large cell surface glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. Plays a role in adhesion and cell-cell interactions, metastasis and signaling. May provide a protective layer on epithelial surfaces. Direct or indirect interaction with actin cytoskeleton. Its cytoplasmic tail (MUC1CT) is involved in several signaling pathways, including those involving Ras, beta-catenin, p120 catenin, p53 and estrogen receptor alpha. MUC1CT also forms complexes with transcription factors, and then translocates to the nucleus by an unknown mechanism, where it is believed to influence the transcription of their target genes. MUC1CT has also been proposed to localize to mitochondrial membranes under conditions of genotoxic stress, where it attenuates the apoptotic pathway in response and confers resistance to apoptosis-inducing drugs. Aberrantly glycosylated forms expressed in human epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Nine alternatively spliced isoforms have been described. Isoforms 5 and 9 are secreted. Isoform 7, expressed only in tumor cells, is a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling. Can bind to GRB2 adapter protein.

Protein type: Tumor suppressor; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Actin-binding; Cell adhesion

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: extracellular space; cell surface; Golgi lumen; integral to plasma membrane; apical plasma membrane; nuclear chromatin; cytoplasm; vesicle

Molecular Function: protein binding; p53 binding; transcription cofactor activity

Biological Process: protein amino acid O-linked glycosylation; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; regulation of transcription from RNA polymerase II promoter in response to stress; cellular protein metabolic process; O-glycan processing; post-translational protein modification; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

Disease: Medullary Cystic Kidney Disease 1
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 Research Articles on MUC1    1. The MUC1-associated sLe(a) is generated in these cells after introduction of MUC1 cDNA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MUC1 recombinant proteinDiseases associated with MUC1 recombinant protein
 Products by Pathway  Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Termination Of O-glycan Biosynthesis Pathway antibodies  Termination Of O-glycan Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1825 publications with MUC1 and Neoplasms
 Breast Neoplasms Antibodies  >571 publications with MUC1 and Breast Neoplasms
 Lung Neoplasms Antibodies  >190 publications with MUC1 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >167 publications with MUC1 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >157 publications with MUC1 and Ovarian Neoplasms
 Disease Models, Animal Antibodies  >151 publications with MUC1 and Disease Models, Animal
 Inflammation Antibodies  >109 publications with MUC1 and Inflammation
 Necrosis Antibodies  >101 publications with MUC1 and Necrosis
 Liver Neoplasms Antibodies  >97 publications with MUC1 and Liver Neoplasms
 Liver Diseases Antibodies  >72 publications with MUC1 and Liver Diseases
Organs/Tissues associated with MUC1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >482 publications with MUC1 and Lung
 Stomach Antibodies  >196 publications with MUC1 and Stomach
 Pancreas Antibodies  >190 publications with MUC1 and Pancreas
 Liver Antibodies  >164 publications with MUC1 and Liver
 Intestine Antibodies  >146 publications with MUC1 and Intestine
 Eye Antibodies  >96 publications with MUC1 and Eye
 Prostate Antibodies  >88 publications with MUC1 and Prostate
 Kidney Antibodies  >83 publications with MUC1 and Kidney
 Uterus Antibodies  >72 publications with MUC1 and Uterus
 Ovary Antibodies  >55 publications with MUC1 and Ovary
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