B9UIY3
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UniProt Protein Name
Mucroporin
UniProt Synonym Protein Names
Antimicrobial peptide 36.21
UniProt Entry Name
MUCR_LYCMC
UniProt Comments for Mucroporin
Function: Cationic host defense peptide that have antibacterial activity by breaking membranes. Is more effective on Gram-positive than on Gram-negative bacteria. Has minimum inhibitory concentrations of MIC=>100 µg/ml against E.coli AB94012, MIC=>100 µg/ml against P.aeruginosa AB93066, MIC=25 µg/ml against B.thuringiensis AB92037, MIC=50 µg/ml against B.subtilis AB91021, MIC=25 µg/ml against S.aureus AB94004, and MIC=25 µg/ml against the methicillin-resistant coagulase-negative Staphylococcus. Its synthetic analog mucroporin-M1 is more effective. Ref.1
Subcellular location: Secreted
By similarity. Target cell membrane. Note: Forms a helical membrane channel in the prey
By similarity.
Tissue specificity: Expressed by the venom gland. Ref.1
Miscellaneous: Minimum inhibitory concentrations (MIC) for Mucroporin-1 analog are the following: MIC=12.5 µg/ml against E.coli AB94012, MIC=100 µg/ml against P.aeruginosa AB93066, MIC=25 µg/ml against B.thuringiensis AB92037, MIC=25 µg/ml against B.subtilis AB91021, MIC=5 µg/ml against S.aureus AB94004, and MIC=5 µg/ml against the methicillin-resistant coagulase-negative Staphylococcus. Furthermore, this analog is as effective against antibiotic-resistant pathogens as it is against antibiotic-sensitive pathogens.
Sequence similarities: Belongs to the short cationic antimicrobial peptide family.
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