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ABCB4 recombinant protein :: Multidrug resistance protein 3 (ABCB4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS952304 ABCB4 recombinant protein
Unit / Price
0.5 mg (E-Coli)  /  $835 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,170 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,835 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Multidrug resistance protein 3 (ABCB4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human Multidrug resistance protein 3 (ABCB4) , partial

 Product Gene Name   

ABCB4 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    614-696; Partial
 Sequence    HSELMKKEGV YFKLVNMQTS GSQIQSEEFE LNDEKAATRM APNGWKSRLF RHSTQKNLKN SQMCQKSLDV ETDGLEANVP PVS
 OMIM    171060
 3D Structure    ModBase 3D Structure for P21439
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABCB4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for ABCB4. It may not necessarily be applicable to this product.
 NCBI GI #    4505771
 NCBI GeneID    5244
 NCBI Accession #    NP_000434.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000443.3 [Other Products]
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 UniProt Primary Accession #    P21439 [Other Products]
 UniProt Secondary Accession #    Q14813; A0A2V7; A4D1D3; A4D1D4; A4D1D5; D6W5P3; D6W5P4 [Other Products]
 UniProt Related Accession #    P21439 [Other Products]
 Molecular Weight    135,259 Da
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 NCBI Official Full Name    phosphatidylcholine translocator ABCB4 isoform A
 NCBI Official Synonym Full Names    ATP binding cassette subfamily B member 4
 NCBI Official Symbol    ABCB4 [Similar Products]
 NCBI Official Synonym Symbols   
GBD1; ICP3; MDR2; MDR3; PGY3; ABC21; MDR2/3; PFIC-3
[Similar Products]
 NCBI Protein Information    phosphatidylcholine translocator ABCB4
 UniProt Protein Name    Phosphatidylcholine translocator ABCB4
 UniProt Synonym Protein Names   
ATP-binding cassette sub-family B member 4
 Protein Family    ABC transporter B family
 UniProt Gene Name    ABCB4 [Similar Products]
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 NCBI Summary for ABCB4    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABCB4    Energy-dependent phospholipid efflux translocator that acts as a positive regulator of biliary lipid secretion. Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes. Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts (PubMed:7957936, PubMed:8898203, PubMed:9366571, PubMed:17523162, PubMed:23468132, PubMed:24806754, PubMed:24723470, PubMed:24594635, PubMed:21820390). Plays a role in the recruitment of phosphatidylcholine (PC), phosphatidylethanolamine (PE) and sphingomyelin (SM) molecules to nonraft membranes and to fu rther enrichment of SM and cholesterol in raft membranes in hepatocytes (PubMed:23468132). Required for proper phospholipid bile formation (). Indirectly involved in cholesterol efflux activity from hepatocytes into the canalicular lumen in the presence of bile salts in an ATP-dependent manner (PubMed:24045840). Promotes biliary phospholipid secretion as canaliculi-containing vesicles from the canalicular plasma membrane (PubMed:9366571, PubMed:28012258). In cooperation with ATP8B1, functions to protect hepatocytes from the deleterious detergent activity of bile salts (PubMed:21820390). Does not confer multidrug resistance ().
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 Research Articles on ABCB4    1. Several members of a family exhibited cholestasis and were found to have a substitution of glycine 68 by arginine in ABCB4 due to a missense mutation at base 202. The 18-year-old propositus was heterozygous for this mutation and also suffered acute pancreatitis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ABCB4 recombinant proteinDiseases associated with ABCB4 recombinant protein
 Products by Pathway  Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC Transporters Pathway antibodies  ABC Transporters Pathway Diagram
 ABC-family Proteins Mediated Transport Pathway antibodies  ABC-family Proteins Mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Nuclear Receptors In Lipid Metabolism And Toxicity Pathway antibodies  Nuclear Receptors In Lipid Metabolism And Toxicity Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >134 publications with ABCB4 and Liver Diseases
 Cholestasis Antibodies  >129 publications with ABCB4 and Cholestasis
 Fibrosis Antibodies  >49 publications with ABCB4 and Fibrosis
 Liver Cirrhosis Antibodies  >45 publications with ABCB4 and Liver Cirrhosis
 Intrahepatic Cholestasis of Pregnancy Antibodies  >42 publications with ABCB4 and Intrahepatic Cholestasis of Pregnancy
 Cholangitis Antibodies  >36 publications with ABCB4 and Cholangitis
 Disease Models, Animal Antibodies  >33 publications with ABCB4 and Disease Models, Animal
 Liver Cirrhosis, Biliary Antibodies  >30 publications with ABCB4 and Liver Cirrhosis, Biliary
 Inflammation Antibodies  >30 publications with ABCB4 and Inflammation
 Cholangitis, Sclerosing Antibodies  >27 publications with ABCB4 and Cholangitis, Sclerosing
Organs/Tissues associated with ABCB4 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >183 publications with ABCB4 and Liver
 Blood Antibodies  >46 publications with ABCB4 and Blood
 Intestine Antibodies  >12 publications with ABCB4 and Intestine
 Brain Antibodies  >11 publications with ABCB4 and Brain
 Kidney Antibodies  >10 publications with ABCB4 and Kidney
 Mixed Antibodies  >9 publications with ABCB4 and Mixed
 Muscle Antibodies  >7 publications with ABCB4 and Muscle
 Embryonic Tissue Antibodies  >5 publications with ABCB4 and Embryonic Tissue
 Pancreas Antibodies  >2 publications with ABCB4 and Pancreas
 Testis Antibodies  >2 publications with ABCB4 and Testis
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