NP_032856.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
phosphatidylcholine translocator ABCB4
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 4
NCBI Protein Information
phosphatidylcholine translocator ABCB4
UniProt Protein Name
Phosphatidylcholine translocator ABCB4
UniProt Synonym Protein Names
ATP-binding cassette sub-family B member 4
UniProt Comments for MDR3
ABCB4: a transporter that mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human ABCB4 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte. Interacts with HAX1. Defects are the cause of gallstones, and progressive familial intrahepatic cholestasis 3, an autosomal recessive liver disorder that progresses to cirrhosis and liver failure before adulthood. Two alternatively spliced human isoforms have been described.
Protein type: EC 3.6.3.44; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family
Chromosomal Location of Human Ortholog: 5 A1|5 3.43 cM
Cellular Component: actin cytoskeleton; apical plasma membrane; cytoplasm; cytosol; focal adhesion; Golgi membrane; intercellular canaliculus; membrane; nucleoplasm; plasma membrane
Molecular Function: ATPase activity, coupled to transmembrane movement of substances; phosphatidylcholine transmembrane transporter activity
Biological Process: bile acid secretion; lipid homeostasis; multidrug transport; phospholipid translocation; positive regulation of cholesterol transport
Research Articles on MDR3
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Pathways associated with MDR3 recombinant protein
Diseases associated with MDR3 recombinant protein
Organs/Tissues associated with MDR3 recombinant protein
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