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MOG recombinant protein :: Myelin Oligodendrocyte Glycoprotein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS197031 MOG recombinant protein
Unit / Price
0.01 mg  /  $195 +1 FREE 8GB USB
0.05 mg  /  $280 +1 FREE 8GB USB
1 mg  /  $1,965 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin Oligodendrocyte Glycoprotein (MOG), Recombinant Protein

 Also Known As   

Recombinant Human Myelin Oligodendrocyte Glycoprotein

 Product Gene Name   

MOG recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.11 (29624758..29640149). Location: 6p22.1
 OMIM    159465
 3D Structure    ModBase 3D Structure for Q16653
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 Host    E Coli
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 Specificity    Human Myelin Oligodendrocyte Glycoprotein
 Purity/Purification    Greater than 95% as determined by SDS-PAGE and RPHPLC.
 Form/Format    Lyophilized white powder from sterile-filtered solution in 20mM sodium acetate buffer, pH 4.0 and 0.3M NaCl. Purified by proprietary chromatographic techniques.
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 Solubility    Reconstitute lyophilized MOG in sterile 10mM acetic acid to no less than 100ug/ml which can be further diluted in other aqueous solutions as needed.
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 Preparation and Storage    Although stable at room temperature for 3 weeks, the lyophilized product is best stored at or below -20 degree C. Upon reconstitution, MOG can be stored at 4 degree C for up to 1 week but is best stored at or below -20 degree C for longer periods of time. Addition of a carrier protein (such as 0.1% HSA or BSA) is recommended for long-term storage.
 Other Notes    Small volumes of MOG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MOG recombinant protein

   Myelin Oligodendrocyte Glycoprotein (MOG) is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Given its localization, it is a prime target antigen in immunemediated demyelination. MOG is involved in completion and maintenance of the myelin sheath and in cell-cell communication. MOG is differentially expressed in the dorsolateral prefrontal cortex and in the temporal lobe from patients with schizophrenia.

Recombinant Human MOG produced in E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids with a molecular weight of 15.2kDa. It is fused to a 6X His-tag at the C-terminus.
NCBI/Uniprot data below describe general gene information for MOG. It may not necessarily be applicable to this product.
 NCBI GI #    56788389
 NCBI GeneID    4340
 NCBI Accession #    NP_001008229.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001008228.2 [Other Products]
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 UniProt Primary Accession #    Q16653 [Other Products]
 UniProt Secondary Accession #    O00713; O00714; O00715; Q13054; Q13055; Q14855; Q5JNY1; Q5JNY4; A6NDR4; A8MY31; B0UZR9 [Other Products]
 UniProt Related Accession #    Q16653; Q29ZN8; Q29ZN9; Q56UX9; Q56UY0; Q59EJ6; Q5JNX7; Q5JNY2; Q5SSB8; Q5STL9 [Other Products]
 Molecular Weight    28,193 Da [Similar Products]
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 NCBI Official Full Name    myelin-oligodendrocyte glycoprotein isoform alpha3
 NCBI Official Synonym Full Names    myelin oligodendrocyte glycoprotein
 NCBI Official Symbol    MOG [Similar Products]
 NCBI Official Synonym Symbols   
MOGIG2; MGC26137
[Similar Products]
 NCBI Protein Information    myelin-oligodendrocyte glycoprotein; MOG Ig-AluB; OTTHUMP00000029120; OTTHUMP00000029121; OTTHUMP00000029122; OTTHUMP00000029123; OTTHUMP00000029124; OTTHUMP00000029125; OTTHUMP00000029126; OTTHUMP00000029127; OTTHUMP00000109158; OTTHUMP00000214867; OTTHUMP00000214868; OTTHUMP00000214869
 UniProt Protein Name    Myelin-oligodendrocyte glycoprotein
 Protein Family    Molybdopterin adenylyltransferase
 UniProt Gene Name    MOG [Similar Products]
 UniProt Entry Name    MOG_HUMAN
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 NCBI Summary for MOG    The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
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 UniProt Comments for MOG    MOG: Mediates homophilic cell-cell adhesion. Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell- cell communication. Defects in MOG are the cause of narcolepsy type 7 (NRCLP7). Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed. Belongs to the immunoglobulin superfamily. BTN/MOG family. 10 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p22.1

Cellular Component: plasma membrane; integral to membrane

Biological Process: central nervous system development; positive regulation of MyD88-dependent toll-like receptor signaling pathway; cell adhesion

Disease: Narcolepsy 7
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 Research Articles on MOG    1. Report provides evidence that the humoral immune response against MOG in children is specific for demyelinating inflammatory CNS disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with MOG recombinant proteinOrgans/Tissues associated with MOG recombinant protein
 Disease Name  Pubmed Publications
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >642 publications with MOG and Encephalomyelitis, Autoimmune, Experimental
 Inflammation Antibodies  >231 publications with MOG and Inflammation
 Neoplasms Antibodies  >31 publications with MOG and Neoplasms
 Mental Disorders Antibodies  >23 publications with MOG and Mental Disorders
 Neurodegenerative Diseases Antibodies  >19 publications with MOG and Neurodegenerative Diseases
 Stroke Antibodies  >11 publications with MOG and Stroke
 Pain Antibodies  >10 publications with MOG and Pain
 Diabetes Mellitus Antibodies  >9 publications with MOG and Diabetes Mellitus
 Respiratory Tract Diseases Antibodies  >7 publications with MOG and Respiratory Tract Diseases
 Genetic Diseases, Inborn Antibodies  >7 publications with MOG and Genetic Diseases, Inborn
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >326 publications with MOG and Brain
 Spinal Cord Antibodies  >234 publications with MOG and Spinal Cord
 Kidney Antibodies  >9 publications with MOG and Kidney
 Intestine Antibodies  >7 publications with MOG and Intestine
 Heart Antibodies  >3 publications with MOG and Heart
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