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MBP recombinant protein :: Myelin basic protein Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS717422
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Unit / Price
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin basic protein (MBP), Recombinant Protein

 Also Known As   

Recombinant Human Myelin basic protein

 Product Synonym Names    Myelin A1 protein; Myelin membrane encephalitogenic protein
 Product Gene Name   

MBP recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    134-304
 Sequence    MASQKRPSQR HGSKYLATAS TMDHARHGFL PRHRDTGILD SIGRFFGGDR GAPKRGSGKV PWLKPGRSPL PSHARSQPGL CNMYKDSHHP ARTAHYGSLP QKSHGRTQDE NPVVHFFKNI VTPRTPPPSQ GKGRGLSLSR FSWGAEGQRP GFGYGGRASD YKSAHKGFKG VDAQGTLSKI FKLGGRDSRS GSPMARR
 OMIM    159430
 3D Structure    ModBase 3D Structure for P02686
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MBP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for MBP recombinant protein

   The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in ryelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of th potentially having a specialized function. Induces T-cell proliferation.
 Product Categories/Family for MBP recombinant protein    Neuroscience
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 SDS-Page of MBP recombinant protein    MBP recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for MBP. It may not necessarily be applicable to this product.
 NCBI GI #    68509930
 NCBI GeneID    4155
 NCBI Accession #    NP_001020252.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025081.1 [Other Products]
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 UniProt Primary Accession #    P02686 [Other Products]
 UniProt Secondary Accession #    Q15337; Q15338; Q15339; Q15340; A4FU54; A6NI84; A8MY86; A8MYL4; B3KY66; B7ZKS2; B7ZKS4 [Other Products]
 UniProt Related Accession #    P02686 [Other Products]
 Molecular Weight    25.6kD
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 NCBI Official Full Name    myelin basic protein isoform 1
 NCBI Official Synonym Full Names    myelin basic protein
 NCBI Official Symbol    MBP [Similar Products]
 NCBI Protein Information    Golli-MBP; myelin basic protein
 UniProt Protein Name    Myelin basic protein
 UniProt Synonym Protein Names   
Myelin A1 protein; Myelin membrane encephalitogenic protein
 Protein Family    Myelin basic protein
 UniProt Gene Name    MBP [Similar Products]
 UniProt Synonym Gene Names    MBP [Similar Products]
 UniProt Entry Name    MBP_HUMAN
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 NCBI Summary for MBP    The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MBP    The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
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Product References and Citations for MBP recombinant protein

   Amino acid sequence of the encephalitogenic basic protein from human myelin.Carnegie P.R.Biochem. J. 123:57-67(1971) Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant.Roth H.J., Kronquist K.E., Pretorius P.J., Crandall B.F., Campagnoni A.T.J. Neurosci. Res. 16:227-238(1986) Identification of three forms of human myelin basic protein by cDNA cloning.Kamholz J., de Ferra F., Puckett C., Lazzarini R.A.Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986) Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning.Roth H.J., Kronquist K.E., de Rosbo N., Crandall B.F., Campagnoni A.T.J. Neurosci. Res. 17:321-328(1987) The organization of the human myelin basic protein gene. Comparison with the mouse gene.Streicher R., Stoffel W.Biol. Chem. Hoppe-Seyler 370:503-510(1989) The human myelin basic protein gene is included within a 179-kilobase transcription unit expression in the immune and central nervous systems.Pribyl T.M., Campagnoni C.W., Kampf K., Kashima T., Handley V.W., McMahon J., Campagnoni A.T.Proc. Natl. Acad. Sci. U.S.A. 90:10695-10699(1993) Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein.Nye S.H., Pelfrey C.M., Burkwit J.J., Voskuhl R.R., Lenardo M.J., Mueller J.P.Mol. Immunol. 32:1131-1141(1995) Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing.Zihni C., Mitsopoulos C., Tavares I.A., Baum B., Ridley A.J., Morris J.D.J. Biol. Chem. 282:6484-6493(2007) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.Sci. Signal. 2:RA46-RA46(2009) The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal.Smith G.S., Seymour L.V., Boggs J.M., Harauz G.Biochem. Biophys. Res. Commun. 422:670-675(2012) Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation.Jin Z., Fu Z., Yang J., Troncosco J., Everett A.D., Van Eyk J.E.Proteomics 13:2682-2691(2013) Conformation of a tetradecapeptide epitope of myelin basic protein.Mendz G.L., Barden J.A., Martenson R.E.Eur. J. Biochem. 231:659-666(1995) Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis.Ridsdale R.A., Beniac D.R., Tompkins T.A., Moscarello M.A., Harauz G.J. Biol. Chem. 272:4269-4275(1997) Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.Li Y., Li H., Martin R., Mariuzza R.A.J. Mol. Biol. 304:177-188(2000) Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.Li Y., Li H., Dimasi N., McCormick J.K., Martin R., Schuck P., Schlievert P.M., Mariuzza R.A.Immunity 14:93-104(2001) Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.Li Y., Huang Y., Lue J., Quandt J.A., Martin R., Mariuzza R.A.EMBO J. 24:2968-2979(2005)
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 Research Articles on MBP    1. Reduced myelin basic protein-induced CD4+ T-cell autoreactivity in interferon-beta-treated multiple sclerosis patients may be mediated by monocyte-derived interleukin-10
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with MBP recombinant proteinDiseases associated with MBP recombinant protein
 Products by Pathway  Pathway Diagram
 Glial Cell Differentiation Pathway antibodies  Glial Cell Differentiation Pathway Diagram
 MAPK Cascade Pathway antibodies  MAPK Cascade Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2770 publications with MBP and Nervous System Diseases
 Demyelinating Diseases Antibodies  >2001 publications with MBP and Demyelinating Diseases
 Brain Diseases Antibodies  >1763 publications with MBP and Brain Diseases
 Encephalomyelitis, Autoimmune, Experimental Antibodies  >1208 publications with MBP and Encephalomyelitis, Autoimmune, Experimental
 Cardiovascular Diseases Antibodies  >726 publications with MBP and Cardiovascular Diseases
 Inflammation Antibodies  >520 publications with MBP and Inflammation
 Hypertension Antibodies  >424 publications with MBP and Hypertension
 Necrosis Antibodies  >271 publications with MBP and Necrosis
 Heart Diseases Antibodies  >204 publications with MBP and Heart Diseases
 Kidney Diseases Antibodies  >153 publications with MBP and Kidney Diseases
Organs/Tissues associated with MBP recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3747 publications with MBP and Blood
 Brain Antibodies  >2003 publications with MBP and Brain
 Nerve Antibodies  >1475 publications with MBP and Nerve
 Spinal Cord Antibodies  >715 publications with MBP and Spinal Cord
 Heart Antibodies  >708 publications with MBP and Heart
 Kidney Antibodies  >271 publications with MBP and Kidney
 Muscle Antibodies  >255 publications with MBP and Muscle
 Spleen Antibodies  >249 publications with MBP and Spleen
 Lymph Node Antibodies  >243 publications with MBP and Lymph Node
 Lymph Antibodies  >242 publications with MBP and Lymph
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