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MPZ recombinant protein :: Myelin protein P0 (MPZ) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS961866
SDS-PAGE
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myelin protein P0 (MPZ), Recombinant Protein

 Also Known As   

Recombinant Human Myelin protein P0 (MPZ)

 Product Synonym Names    Myelin protein P0; Myelin peripheral protein; MPP; Myelin protein zero
 Product Gene Name   

MPZ recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    30-153
 Sequence    I VVYTDREVHG AVGSRVTLHC SFWSSEWVSD DISFTWRYQP EGGRDAISIF HYAKGQPYID EVGTFKERIQ WVGDPRWKDG SIVIHNLDYS DNGTFTCDVK NPPDIVGKTS QVTLYVFEKV PTR
 OMIM    607791
 3D Structure    ModBase 3D Structure for P25189
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol; lyophilization may be available upon request.
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of MPZ recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for MPZ recombinant protein

   Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae.
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 SDS-PAGE of MPZ recombinant protein    MPZ recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for MPZ. It may not necessarily be applicable to this product.
 NCBI GI #    295391071
 NCBI GeneID    4359
 NCBI Accession #    NP_000521.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000530.6 [Other Products]
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 UniProt Primary Accession #    P25189 [Other Products]
 UniProt Secondary Accession #    Q16072; Q5VTH4; Q92677; Q9BR67 [Other Products]
 UniProt Related Accession #    P25189 [Other Products]
 Molecular Weight    34,387 Da
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 NCBI Official Full Name    myelin protein P0
 NCBI Official Synonym Full Names    myelin protein zero
 NCBI Official Symbol    MPZ [Similar Products]
 NCBI Official Synonym Symbols   
P0; CHM; DSS; MPP; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; HMSNIB
[Similar Products]
 NCBI Protein Information    myelin protein P0; myelin peripheral protein; Charcot-Marie-Tooth neuropathy 1B
 UniProt Protein Name    Myelin protein P0
 UniProt Synonym Protein Names   
Myelin peripheral protein; MPP; Myelin protein zero
 Protein Family    Myelin protein
 UniProt Gene Name    MPZ [Similar Products]
 UniProt Synonym Gene Names    MPP [Similar Products]
 UniProt Entry Name    MYP0_HUMAN
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 NCBI Summary for MPZ    This gene encodes a major structural protein of peripheral myelin. Mutations in this gene result in the autosomal dominant form of Charcot-Marie-Tooth disease type 1 and other polyneuropathies. [provided by RefSeq, Apr 2010]
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 UniProt Comments for MPZ    myelin P0: a structural protein in peripheral nervous system Schwann cells. Forms an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae. Defects cause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, congenital hypomyelination neuropathy, and Roussy-Levy syndrome.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: integral to plasma membrane; plasma membrane; myelin sheath

Molecular Function: structural molecule activity

Biological Process: synaptic transmission; intercellular junction maintenance

Disease: Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive; Charcot-marie-tooth Disease, Demyelinating, Type 1b; Hypertrophic Neuropathy Of Dejerine-sottas; Charcot-marie-tooth Disease, Dominant Intermediate D; Charcot-marie-tooth Disease, Axonal, Type 2j; Charcot-marie-tooth Disease, Axonal, Type 2i; Roussy-levy Hereditary Areflexic Dystasia
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 Research Articles on MPZ    1. This study demonistrated that The mutation c.419C>G of MPZ exhibited relatively late onset and slowly progressive CMT1 phenotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MPZ recombinant proteinPathways associated with MPZ recombinant protein
 Reference Product  PubMed Publications
 PMP22 recombinant protein  >114 publications with MPZ and PMP22
 EGR2 recombinant protein  >56 publications with MPZ and EGR2
 GJB1 recombinant protein  >48 publications with MPZ and GJB1
 SOX10 recombinant protein  >16 publications with MPZ and SOX10
 GDAP1 recombinant protein  >14 publications with MPZ and GDAP1
 PRX recombinant protein  >11 publications with MPZ and PRX
 HSPB8 recombinant protein  >5 publications with MPZ and HSPB8
 KIF1B recombinant protein  >5 publications with MPZ and KIF1B
 MED25 recombinant protein  >2 publications with MPZ and MED25
 NRG1 recombinant protein  >1 publications with MPZ and NRG1
 Products by Pathway  Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
Diseases associated with MPZ recombinant proteinOrgans/Tissues associated with MPZ recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >247 publications with MPZ and Nervous System Diseases
 Peripheral Nervous System Diseases Antibodies  >227 publications with MPZ and Peripheral Nervous System Diseases
 Hereditary Sensory and Motor Neuropathy Antibodies  >210 publications with MPZ and Hereditary Sensory and Motor Neuropathy
 Charcot-Marie-Tooth Disease Antibodies  >207 publications with MPZ and Charcot-Marie-Tooth Disease
 Demyelinating Diseases Antibodies  >61 publications with MPZ and Demyelinating Diseases
 Disease Models, Animal Antibodies  >19 publications with MPZ and Disease Models, Animal
 Nerve Degeneration Antibodies  >14 publications with MPZ and Nerve Degeneration
 Neoplasms Antibodies  >7 publications with MPZ and Neoplasms
 Hypertrophy Antibodies  >5 publications with MPZ and Hypertrophy
 Charcot-Marie-Tooth disease, Type 4E Antibodies  >3 publications with MPZ and Charcot-Marie-Tooth disease, Type 4E
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >165 publications with MPZ and Nerve
 Muscle Antibodies  >48 publications with MPZ and Muscle
 Brain Antibodies  >36 publications with MPZ and Brain
 Blood Antibodies  >22 publications with MPZ and Blood
 Skin Antibodies  >6 publications with MPZ and Skin
 Embryonic Tissue Antibodies  >5 publications with MPZ and Embryonic Tissue
 Eye Antibodies  >5 publications with MPZ and Eye
 Heart Antibodies  >4 publications with MPZ and Heart
 Pituitary Gland Antibodies  >4 publications with MPZ and Pituitary Gland
 Ear Antibodies  >4 publications with MPZ and Ear
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