NP_000524.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
26,274 Da
NCBI Official Full Name
myelin proteolipid protein isoform 1
NCBI Official Synonym Full Names
proteolipid protein 1
NCBI Official Synonym Symbols
PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20 [Similar Products]
NCBI Protein Information
myelin proteolipid protein
UniProt Protein Name
Myelin proteolipid protein
UniProt Synonym Protein Names
Lipophilin
UniProt Synonym Gene Names
NCBI Summary for PLP1
This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
UniProt Comments for PLP1
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
Research Articles on PLP1
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Products associated with PLP1 recombinant protein
Pathways associated with PLP1 recombinant protein
Diseases associated with PLP1 recombinant protein
Organs/Tissues associated with PLP1 recombinant protein
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