AAD13299.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28,662 Da
NCBI Official Full Name
myeloid cell leukemia sequence 1
NCBI Official Synonym Full Names
myeloid cell leukemia 1
NCBI Official Synonym Symbols
TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT [Similar Products]
NCBI Protein Information
induced myeloid leukemia cell differentiation protein Mcl-1
UniProt Protein Name
Induced myeloid leukemia cell differentiation protein Mcl-1
UniProt Synonym Protein Names
Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
UniProt Synonym Gene Names
UniProt Entry Name
MCL1_HUMAN
NCBI Summary for MCL1
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
UniProt Comments for MCL1
MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.
Protein type: Channel, misc.; Mitochondrial; Membrane protein, integral; Inhibitor; Apoptosis
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: nucleoplasm; mitochondrial outer membrane; membrane; mitochondrion; mitochondrial matrix; cytoplasm; integral to membrane; nucleus; cytosol
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding
Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; multicellular organismal development; cell fate determination; cellular homeostasis
Research Articles on MCL1
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Products associated with MCL1 recombinant protein
Pathways associated with MCL1 recombinant protein
Diseases associated with MCL1 recombinant protein
Organs/Tissues associated with MCL1 recombinant protein
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