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MCL1 recombinant protein :: Myeloid Cell Leukemia Sequence 1 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2030049 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-Page
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $265 +1 FREE 8GB USB
0.1 mg  /  $410 +1 FREE 8GB USB
0.2 mg  /  $505 +1 FREE 8GB USB
0.5 mg  /  $980 +1 FREE 8GB USB
1 mg  /  $1,445 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Myeloid Cell Leukemia Sequence 1 (MCL1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Myeloid Cell Leukemia Sequence 1, Bcl2 Related (MCL1)

 Product Gene Name   

MCL1 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: Myeloid Cell Leukemia Sequence 1 (MBS2026311)
Antigen: Myeloid Cell Leukemia Sequence 1 (MBS2030049)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.
MGSSHHHHH H SSGLVPRGSH MASMTGGQQM GRGSEF-RNA VI GLNLYCGGAG LGAGSGGATR PGGRLLATEK EASARREIGG GEAGAVIGGS AGASPPSTLT PDSRRVARPP PIGAEVPDVT ATPARLLFFA PTRRAAPLEE MEAPAADAIM SPEEELDGYE PEPLGKRPAV LPLLELVGES GNNTSTDGSL PSTPPPAEEE EDELYRQSLE IISRYLREQA TGAKDTKPMG RSGATSRKAL ETLRRVGDGV QRNHETAFQG MLRKLDIKNE DDVKSLSRVM IHVFSDGVTN WGRIVTLISF GAFVAKHLKT INQESCIEPL AESITDVLVR TKRDWLVKQR GWDGFVEFFH VEDLEGGI
 OMIM    159552
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 Host    Host: E Coli
Source: Prokaryotic expression
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 Purity/Purification    >95%
 Form/Format    Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
 Concentration    5.8 (lot specific)
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 Predicted Molecular Mass    38.4kDa
 Accurate Molecular Mass (KD)    23kDa
 Endotoxin    <1.0EU per 1ug (determined by the LAL method)
 Expression System    Prokaryotic expression
 Tag    two N-terminal Tags, His-tag and T7-tag
 Organism Species    Homo sapiens (Human)
 Fragment    Arg6~Ile328
 Usage    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of MCL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for MCL1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-Page of MCL1 recombinant protein    MCL1 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for MCL1. It may not necessarily be applicable to this product.
 NCBI GI #    4235637
 NCBI GeneID    4170
 NCBI Accession #    AAD13299.1 [Other Products]
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 UniProt Secondary Accession #    Q9HD91; Q9NRQ3; Q9NRQ4; Q9UHR7; Q9UHR8; Q9UHR9; Q9UNJ1; B2R6B2; D3DV03; D3DV04 [Other Products]
 UniProt Related Accession #    Q07820 [Other Products]
 Molecular Weight    28,662 Da
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 NCBI Official Full Name    myeloid cell leukemia sequence 1
 NCBI Official Synonym Full Names    myeloid cell leukemia 1
 NCBI Official Symbol    MCL1 [Similar Products]
 NCBI Official Synonym Symbols   
TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT
[Similar Products]
 NCBI Protein Information    induced myeloid leukemia cell differentiation protein Mcl-1
 UniProt Protein Name    Induced myeloid leukemia cell differentiation protein Mcl-1
 UniProt Synonym Protein Names   
Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT
 Protein Family    Minichromosome loss protein
 UniProt Gene Name    MCL1 [Similar Products]
 UniProt Synonym Gene Names    BCL2L3; Bcl2-L-3 [Similar Products]
 UniProt Entry Name    MCL1_HUMAN
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 NCBI Summary for MCL1    This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
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 UniProt Comments for MCL1    MCL1: a myeloid cell leukemia protein of the Bcl-2 family of proteins. Two alternatively spliced transcripts encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Protein type: Channel, misc.; Mitochondrial; Membrane protein, integral; Inhibitor; Apoptosis

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: nucleoplasm; mitochondrial outer membrane; membrane; mitochondrion; mitochondrial matrix; cytoplasm; integral to membrane; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; protein channel activity; BH3 domain binding

Biological Process: apoptotic mitochondrial changes; DNA damage response, signal transduction resulting in induction of apoptosis; response to cytokine stimulus; multicellular organismal development; cell fate determination; cellular homeostasis
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 Research Articles on MCL1    1. Taken together, this study is the first to not only show that Mcl-1 is a novel target gene of FOXM1 but also suggest that targeting FOXM1/Mcl-1 may be a novel strategy to enhance sensitivity to oxaliplatin in gastric cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with MCL1 recombinant proteinPathways associated with MCL1 recombinant protein
 Reference Product  PubMed Publications
 BAX recombinant protein  >188 publications with MCL1 and BAX
 PMAIP1 recombinant protein  >50 publications with MCL1 and PMAIP1
 BAK1 recombinant protein  >42 publications with MCL1 and BAK1
 BID recombinant protein  >35 publications with MCL1 and BID
 TP53 recombinant protein  >25 publications with MCL1 and TP53
 BBC3 recombinant protein  >19 publications with MCL1 and BBC3
 USP9X recombinant protein  >13 publications with MCL1 and USP9X
 HUWE1 recombinant protein  >5 publications with MCL1 and HUWE1
 BCL2L11 recombinant protein  >4 publications with MCL1 and BCL2L11
 UBC recombinant protein  >1 publications with MCL1 and UBC
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 IL-7 Signaling Pathway antibodies  IL-7 Signaling Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram
Diseases associated with MCL1 recombinant proteinOrgans/Tissues associated with MCL1 recombinant protein
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >64 publications with MCL1 and Lung Neoplasms
 Necrosis Antibodies  >54 publications with MCL1 and Necrosis
 Breast Neoplasms Antibodies  >47 publications with MCL1 and Breast Neoplasms
 Liver Diseases Antibodies  >45 publications with MCL1 and Liver Diseases
 Multiple Myeloma Antibodies  >36 publications with MCL1 and Multiple Myeloma
 Liver Neoplasms Antibodies  >35 publications with MCL1 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >35 publications with MCL1 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >33 publications with MCL1 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >30 publications with MCL1 and Inflammation
 Pancreatic Neoplasms Antibodies  >22 publications with MCL1 and Pancreatic Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >170 publications with MCL1 and Blood
 Lung Antibodies  >89 publications with MCL1 and Lung
 Liver Antibodies  >78 publications with MCL1 and Liver
 Bone Antibodies  >67 publications with MCL1 and Bone
 Bone Marrow Antibodies  >51 publications with MCL1 and Bone Marrow
 Brain Antibodies  >41 publications with MCL1 and Brain
 Prostate Antibodies  >36 publications with MCL1 and Prostate
 Skin Antibodies  >24 publications with MCL1 and Skin
 Vascular Antibodies  >23 publications with MCL1 and Vascular
 Lymph Node Antibodies  >18 publications with MCL1 and Lymph Node
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