NP_005250.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
growth/differentiation factor 8
NCBI Official Synonym Full Names
myostatin
NCBI Official Synonym Symbols
NCBI Protein Information
growth/differentiation factor 8; GDF-8; growth differentiation factor 8
UniProt Protein Name
Growth/differentiation factor 8
UniProt Synonym Protein Names
Myostatin
UniProt Synonym Gene Names
UniProt Entry Name
GDF8_HUMAN
NCBI Summary for MSTN
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]
UniProt Comments for MSTN
MSTN: Acts specifically as a negative regulator of skeletal muscle growth. Defects in MSTN are the cause of muscle hypertrophy (MSLHP). MSLHP is a condition characterized by increased muscle bulk and strength. Affected individuals are exceptionally strong. Belongs to the TGF-beta family.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 2q32.2
Cellular Component: extracellular space; cytoplasm
Molecular Function: heparin binding; identical protein binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; receptor binding
Biological Process: response to gravity; response to muscle activity; muscle development; positive regulation of transcription, DNA-dependent; skeletal muscle regeneration; response to testosterone stimulus; ovulation cycle process; regulation of apoptosis; negative regulation of muscle hypertrophy; skeletal muscle atrophy; response to ethanol; response to heat; response to estrogen stimulus; transforming growth factor beta receptor signaling pathway; regulation of MAPKKK cascade; negative regulation of skeletal muscle growth; response to electrical stimulus; cell development
Disease: Muscle Hypertrophy
Research Articles on MSTN
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Products associated with MSTN active protein
Pathways associated with MSTN active protein
Diseases associated with MSTN active protein
Organs/Tissues associated with MSTN active protein
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