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NMI recombinant protein :: N-Myc Interactor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS144282 NMI recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,665 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

N-Myc Interactor (NMI), Recombinant Protein

 Also Known As   

Recombinant Human N-Myc Interactor

 Product Synonym Names    NMI Human; N-Myc Interactor Human Recombinant; N-myc (and STAT) Interactor
 Product Gene Name   

NMI recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHHHHH SSGLVPRGSH MEADKDDTQQ ILKEHSPDEF IKDEQNKGLI DEITKKNIQL K KEIQKLETE LQEATKEFQI KEDIPETKMK FLSVETPEND SQLSNISCSF QVSSKVPYEI QKGQALITFE KEEVAQNVVS MSKHHVQIKD V NLEVTAKPV PLNSGVRFQV YVEVSKMKIN VTEIPDTLRE DQMRDKLELS FSKSRNGGGE VDRVDYDRQS GSAVITFVEI GVADKILKKK EYPLYINQTC HRVTVSPYTE IHLKKYQIFS GTSKRTVLLT GMEGIQMDEE IVEDLINIHF QRAKNGGGEV DVVKCSLGQP HIAYFEE
 OMIM    603525
 3D Structure    ModBase 3D Structure for Q13287
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    The NMI protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)1mM DTT and 20% glycerol.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.
 Other Notes    Small volumes of NMI recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for NMI recombinant protein

   Description: NMI produced in E Coli is a single, non-glycosylated polypeptide chain containing 327 amino acids (1-307a.a.) and having a molecular mass of 37.2kDa.NMI is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: N-myc-interactor belongs to the oncogene Myc family which has a significant part in cell proliferation, differentiation, and neoplastic transformation. In Addition, NMI cooperates with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA is expressed in small quantities in all human fetal and adult tissues tested except brain and but in large quantities in cancer cell line-myeloid leukemias.
 Product Categories/Family for NMI recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
NCBI/Uniprot data below describe general gene information for NMI. It may not necessarily be applicable to this product.
 NCBI GI #    188219599
 NCBI GeneID    9111
 NCBI Accession #    NP_004679.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004688.2 [Other Products]
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 UniProt Primary Accession #    Q13287 [Other Products]
 UniProt Secondary Accession #    Q53TI8; Q9BVE5; B5BU69 [Other Products]
 UniProt Related Accession #    Q13287 [Other Products]
 Molecular Weight    35,057 Da
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 NCBI Official Full Name    N-myc-interactor
 NCBI Official Synonym Full Names    N-myc (and STAT) interactor
 NCBI Official Symbol    NMI [Similar Products]
 NCBI Protein Information    N-myc-interactor; N-myc interactor
 UniProt Protein Name    N-myc-interactor
 UniProt Synonym Protein Names   
N-myc and STAT interactor
 Protein Family    N-myc-interactor
 UniProt Gene Name    NMI [Similar Products]
 UniProt Synonym Gene Names    Nmi [Similar Products]
 UniProt Entry Name    NMI_HUMAN
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 NCBI Summary for NMI    NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NMI    NMI: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcription factors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 and STAT5. Belongs to the NMI family.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q23

Cellular Component: nucleoplasm; cytoplasm

Molecular Function: protein binding; transcription cofactor activity

Biological Process: transcription from RNA polymerase II promoter; inflammatory response; JAK-STAT cascade
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 Research Articles on NMI    1. identified NMI induction as a novel negative feedback mechanism that decreases IRE1alpha-dependent activation of JNK and apoptosis in cytokine-exposed beta cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NMI recombinant proteinPathways associated with NMI recombinant protein
 Reference Product  PubMed Publications
 MYC recombinant protein  >32 publications with NMI and MYC
 MYCN recombinant protein  >11 publications with NMI and MYCN
 IFI35 recombinant protein  >6 publications with NMI and IFI35
 STAT1 recombinant protein  >6 publications with NMI and STAT1
 STAT5B recombinant protein  >1 publications with NMI and STAT5B
 STAT2 recombinant protein  >1 publications with NMI and STAT2
 Products by Pathway  Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram
Diseases associated with NMI recombinant proteinOrgans/Tissues associated with NMI recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >21 publications with NMI and Cardiovascular Diseases
 Heart Diseases Antibodies  >18 publications with NMI and Heart Diseases
 Learning Disorders Antibodies  >14 publications with NMI and Learning Disorders
 Neoplasm Invasiveness Antibodies  >14 publications with NMI and Neoplasm Invasiveness
 Pain Antibodies  >13 publications with NMI and Pain
 Breast Neoplasms Antibodies  >9 publications with NMI and Breast Neoplasms
 Disease Models, Animal Antibodies  >9 publications with NMI and Disease Models, Animal
 Cognition Disorders Antibodies  >8 publications with NMI and Cognition Disorders
 Myocardial Infarction Antibodies  >8 publications with NMI and Myocardial Infarction
 Inflammation Antibodies  >7 publications with NMI and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >64 publications with NMI and Muscle
 Brain Antibodies  >57 publications with NMI and Brain
 Blood Antibodies  >54 publications with NMI and Blood
 Bladder Antibodies  >39 publications with NMI and Bladder
 Vascular Antibodies  >24 publications with NMI and Vascular
 Bone Antibodies  >14 publications with NMI and Bone
 Eye Antibodies  >14 publications with NMI and Eye
 Liver Antibodies  >10 publications with NMI and Liver
 Lung Antibodies  >9 publications with NMI and Lung
 Kidney Antibodies  >8 publications with NMI and Kidney
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