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Gns recombinant protein :: N-acetylglucosamine-6-sulfatase (Gns) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1361387 Gns recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $930 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $1,005 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,135 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,245 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,360 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,375 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,385 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,440 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,540 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,955 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,060 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,085 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,345 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,710 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

N-acetylglucosamine-6-sulfatase (Gns), Recombinant Protein

 Also Known As   

Recombinant Mouse N-acetylglucosamine-6-sulfatase (Gns)

 Product Synonym Names    N-acetylglucosamine-6-sulfatase; EC=3.1.6.14; Glucosamine-6-sulfatase; G6S
 Product Gene Name   

Gns recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    36-544aa; full length protein
 Sequence    ARRPN VLLLLTDDQD AELGGMTPLK KTKALIGEKG MTFSSAYVPS ALCCPSRASI LTGKYPHNHH VVNNTLEGNC SSKAWQKIQE PYTFPAILKS VCGYQTFFAG KYLNEYGAPD AGGLEHIPLG WSYWYALEKN SKYYNYTLSI NGKARKHGEN YSVDYLTDVL ANLSLDFLDY KSNSEPFFMM ISTPAPHSPW TAAPQYQKAF QNVIAPRNKN FNIHGTNKHW LIRQAKTPMT NSSIRFLDDA FRRRWQTLLS VDDLVEKLVK RLDSTGELDN TYIFYTSDNG YHTGQFSLPI DKRQLYEFDI KVPLLVRGPG IKPNQTSKML VSNIDLGPTI LDLAGYDLNK TQMDGMSLLP ILKGDRNLTW RSDVLVEYQG EGRNVTDPTC PSLSPGVSQC FPDCVCEDAY NNTYACVRTL SSLWNLQYCE FDDQEVFVEV YNITADPDQI TNIAKSIDPE LLGKMNYRLM MLQSCSGPTC RTPGVFDPGY RFDLRLMFNS HGSVRTRRFS KHPL
 3D Structure    ModBase 3D Structure for Q8BFR4
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Gns recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Gns recombinant protein

   The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome.
NCBI/Uniprot data below describe general gene information for Gns. It may not necessarily be applicable to this product.
 NCBI GI #    29789239
 NCBI GeneID    75612
 NCBI Accession #    NP_083640.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_029364.3 [Other Products]
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 UniProt Primary Accession #    Q8BFR4 [Other Products]
 UniProt Secondary Accession #    Q3TWT0; Q8BJJ7; Q8BK91 [Other Products]
 UniProt Related Accession #    Q8BFR4 [Other Products]
 Molecular Weight    61,175 Da
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 NCBI Official Full Name    N-acetylglucosamine-6-sulfatase
 NCBI Official Synonym Full Names    glucosamine (N-acetyl)-6-sulfatase
 NCBI Official Symbol    Gns [Similar Products]
 NCBI Official Synonym Symbols   
G6S; C87209; N28088; AU042285; 2610016K11Rik
[Similar Products]
 NCBI Protein Information    N-acetylglucosamine-6-sulfatase
 UniProt Protein Name    N-acetylglucosamine-6-sulfatase
 UniProt Synonym Protein Names   
Glucosamine-6-sulfatase; G6S
 Protein Family    Non-structural glycoprotein
 UniProt Gene Name    Gns [Similar Products]
 UniProt Synonym Gene Names    G6S [Similar Products]
 UniProt Entry Name    GNS_MOUSE
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 UniProt Comments for Gns    GNS: Defects in GNS are the cause of mucopolysaccharidosis type 3D (MPS3D); also known as Sanfilippo D syndrome. MPS3D is a form of mucopolysaccharidosis type 3, an autosomal recessive lysosomal storage disease due to impaired degradation of heparan sulfate. MPS3 is characterized by severe central nervous system degeneration, but only mild somatic disease. Onset of clinical features usually occurs between 2 and 6 years; severe neurologic degeneration occurs in most patients between 6 and 10 years of age, and death occurs typically during the second or third decade of life. Belongs to the sulfatase family.

Protein type: Hydrolase; Glycan Metabolism - glycosaminoglycan degradation; EC 3.1.6.14

Cellular Component: lysosome

Molecular Function: glycosaminoglycan binding; N-acetylglucosamine-6-sulfatase activity; hydrolase activity; metal ion binding; sulfuric ester hydrolase activity; sulfate binding; catalytic activity

Biological Process: glycosaminoglycan metabolic process; metabolic process
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Gns recombinant proteinDiseases associated with Gns recombinant protein
 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Heparan Sulfate Degradation Pathway antibodies  Heparan Sulfate Degradation Pathway Diagram
 Heparan Sulfate Degradation Pathway antibodies  Heparan Sulfate Degradation Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >19 publications with Gns and Kidney Diseases
 Nervous System Diseases Antibodies  >13 publications with Gns and Nervous System Diseases
 Death Antibodies  >10 publications with Gns and Death
 Proteinuria Antibodies  >9 publications with Gns and Proteinuria
 Brain Diseases Antibodies  >8 publications with Gns and Brain Diseases
 Central Nervous System Diseases Antibodies  >7 publications with Gns and Central Nervous System Diseases
 Hypertension Antibodies  >6 publications with Gns and Hypertension
 Inflammation Antibodies  >5 publications with Gns and Inflammation
 Fever Antibodies  >5 publications with Gns and Fever
 Mucopolysaccharidosis III Antibodies  >5 publications with Gns and Mucopolysaccharidosis III
Organs/Tissues associated with Gns recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >39 publications with Gns and Blood
 Brain Antibodies  >21 publications with Gns and Brain
 Kidney Antibodies  >19 publications with Gns and Kidney
 Liver Antibodies  >12 publications with Gns and Liver
 Skin Antibodies  >9 publications with Gns and Skin
 Muscle Antibodies  >7 publications with Gns and Muscle
 Joint Antibodies  >6 publications with Gns and Joint
 Spleen Antibodies  >6 publications with Gns and Spleen
 Heart Antibodies  >5 publications with Gns and Heart
 Lung Antibodies  >5 publications with Gns and Lung
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