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Add To Compare List Gns recombinant protein :: N-acetylglucosamine-6-sulfatase (Gns) Recombinant Protein Catalog # MBS1361387 Unit / Price 0.02 mg (E-Coli) / $1,085 +1 FREE 8GB USB 0.02 mg (Yeast) / $1,140 +1 FREE 8GB USB 0.1 mg (E-Coli) / $1,265 +1 FREE 8GB USB 0.1 mg (Yeast) / $1,340 +1 FREE 8GB USB 0.02 mg (Baculovirus) / $1,380 +1 FREE 8GB USB 0.02 mg (Mammalian-Cell) / $1,645 +2 FREE 8GB USB 0.1 mg (Baculovirus) / $1,980 +2 FREE 8GB USB 1 mg (E-Coli) / $2,280 +2 FREE 8GB USB 0.1 mg (Mammalian-Cell) / $2,575 +3 FREE 8GB USB 1 mg (Yeast) / $2,650 +3 FREE 8GB USB 1 mg (Baculovirus) / $3,830 +4 FREE 8GB USB 0.5 mg (Mammalian-Cell) / $6,260 +7 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name N-acetylglucosamine-6-sulfatase (Gns), Recombinant Protein Full Product Name Recombinant Mouse N-acetylglucosamine-6-sulfatase (Gns) Product Gene Name Gns recombinant protein[Similar Products] Product Synonym Gene Name Gns[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP Sequence Positions 36-544, Full length protein Sequence ARRPNVLLLL TDDQDAELGG MTPLKKTKAL IGEKGMTFSS AYVPSALCCP SRASILTGKY PHNHHVVNNT LEGNCSSKAW QKIQEPYTFP AILKSVCGYQ TFFAGKYLNE YGAPDAGGLE HIPLGWSYWY ALEKNSKYYN YTLSINGKAR KHGENYSVDY LTDVLANLSL DFLDYKSNSE PFFMMISTPA PHSPWTAAPQ YQKAFQNVIA PRNKNFNIHG TNKHWLIRQA KTPMTNSSIR FLDDAFRRRW QTLLSVDDLV EKLVKRLDST GELDNTYIFY TSDNGYHTGQ FSLPIDKRQL YEFDIKVPLL VRGPGIKPNQ TSKMLVSNID LGPTILDLAG YDLNKTQMDG MSLLPILKGD RNLTWRSDVL VEYQGEGRNV TDPTCPSLSP GVSQCFPDCV CEDAYNNTYA CVRTLSSLWN LQYCEFDDQE VFVEVYNITA DPDQITNIAK SIDPELLGKM NYRLMMLQSC SGPTCRTPGV FDPGYRFDLR LMFNSHGSVR TRRFSKHPL 3D Structure ModBase 3D Structure for Q8BFR4 Host E Coli or Yeast or Baculovirus or Mammalian Cell Purity/Purification Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific) Form/Format Lyophilized or liquid (Format to be determined during the manufacturing process) Tag Information This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information. Sterility Sterile filter available upon request. Endotoxin Low endotoxin available upon request. Species Mouse Preparation and Storage Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of Gns recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for Gns recombinant protein The product of this gene is a lysosomal enzyme found in all cells. It is involved in the catabolism of heparin, heparan sulphate, and keratan sulphate. Deficiency of this enzyme results in the accumulation of undegraded substrate and the lysosomal storage disorder mucopolysaccharidosis type IIID (Sanfilippo D syndrome). Mucopolysaccharidosis type IIID is the least common of the four subtypes of Sanfilippo syndrome. NCBI/Uniprot data below describe general gene information for Gns. It may not necessarily be applicable to this product. NCBI GI # 29789239 NCBI GeneID 75612 NCBI Accession # NP_083640.1 [Other Products] NCBI GenBank Nucleotide # NM_029364.3 [Other Products] UniProt Primary Accession # Q8BFR4 [Other Products] UniProt Secondary Accession # Q3TWT0; Q8BJJ7; Q8BK91[Other Products] UniProt Related Accession # Q8BFR4[Other Products] Molecular Weight 61,175 Da TOP NCBI Official Full Name N-acetylglucosamine-6-sulfatase NCBI Official Synonym Full Names glucosamine (N-acetyl)-6-sulfatase NCBI Official Symbol Gns [Similar Products] NCBI Official Synonym Symbols G6S; C87209; N28088; AU042285; 2610016K11Rik [Similar Products] NCBI Protein Information N-acetylglucosamine-6-sulfatase UniProt Protein Name N-acetylglucosamine-6-sulfatase UniProt Synonym Protein Names Glucosamine-6-sulfatase; G6S Protein Family Non-structural glycoprotein UniProt Gene Name Gns [Similar Products] UniProt Synonym Gene Names G6S [Similar Products] TOP Research Articles on Gns 1. Mice deficient in GNS showed lysosomal storage pathology and a phenotype that closely resembled human MPSIIID. Moreover, treatment of the GNS-deficient animals with GNS-encoding adeno-associated viral (AAV) vectors of serotype 9 delivered to the cerebrospinal fluid completely corrected pathological storage, improved lysosomal functionality in the CNS and somatic tissues, resolved neuroinflammation TOP Precautions All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines. Disclaimer While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information. TOP Pathways associated with Gns recombinant protein Products by Pathway Pathway Diagram Clathrin Derived Vesicle Budding Pathway antibodies Clathrin Derived Vesicle Budding Pathway Diagram Disease Pathway antibodies Disease Pathway Diagram Glycogen Storage Diseases Pathway antibodies Glycogen Storage Diseases Pathway Diagram Glycosaminoglycan Degradation Pathway antibodies Glycosaminoglycan Degradation Pathway Diagram Glycosaminoglycan Degradation Pathway antibodies Glycosaminoglycan Degradation Pathway Diagram Glycosaminoglycan Metabolism Pathway antibodies Glycosaminoglycan Metabolism Pathway Diagram Heparan Sulfate Degradation Pathway antibodies Heparan Sulfate Degradation Pathway Diagram Heparan Sulfate Degradation Pathway antibodies Heparan Sulfate Degradation Pathway Diagram Keratan Sulfate Degradation Pathway antibodies Keratan Sulfate Degradation Pathway Diagram Keratan Sulfate Degradation Pathway antibodies Keratan Sulfate Degradation Pathway Diagram Diseases associated with Gns recombinant protein Disease Name Pubmed Publications Kidney Diseases Antibodies >19 publications with Gns and Kidney Diseases Nervous System Diseases Antibodies >13 publications with Gns and Nervous System Diseases Death Antibodies >10 publications with Gns and Death Proteinuria Antibodies >8 publications with Gns and Proteinuria Brain Diseases Antibodies >8 publications with Gns and Brain Diseases Central Nervous System Diseases Antibodies >7 publications with Gns and Central Nervous System Diseases Hypertension Antibodies >6 publications with Gns and Hypertension Inflammation Antibodies >5 publications with Gns and Inflammation Fever Antibodies >5 publications with Gns and Fever Mucopolysaccharidosis III Antibodies >5 publications with Gns and Mucopolysaccharidosis III Organs/Tissues associated with Gns recombinant protein Organ/Tissue Name Pubmed Publications Blood Antibodies >28 publications with Gns and Blood Kidney Antibodies >15 publications with Gns and Kidney Brain Antibodies >14 publications with Gns and Brain Muscle Antibodies >7 publications with Gns and Muscle Liver Antibodies >5 publications with Gns and Liver Heart Antibodies >4 publications with Gns and Heart Lung Antibodies >4 publications with Gns and Lung Eye Antibodies >4 publications with Gns and Eye Bone Antibodies >3 publications with Gns and Bone Skin Antibodies >3 publications with Gns and Skin TOP © 2006-24 MyBioSource.com. 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