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NAA10 recombinant protein :: NAA,10 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS204403
Unit / Price
0.1 mg  /  $375 +1 FREE 8GB USB
0.5 mg  /  $925 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

NAA,10 (NAA10), Recombinant Protein

 Also Known As   

NAA,10, 1-235aa, Human, His tag, E Coli

 Product Synonym Names    N (alpha)-acetyltransferase 10 NatA catalytic subunit; N (alpha)-acetyltransferase 10; NatA catalytic subunit; ARD1; ARD1A; DXS707; MGC71248; TE2
 Product Gene Name   

NAA10 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X77588 mRNA
 3D Structure    ModBase 3D Structure for P41227
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 Host    E Coli
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 Purity/Purification    > 90% by SDS-PAGE
 Form/Format    Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 5mM DTT, 10% glycerol, 200mM NaCl
 Concentration    1mg/ml (determined by Bradford assay) (lot specific)
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 Antigen Species    Human
 Tag Information    His-tag
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 Preparation and Storage    Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of NAA10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NAA10 recombinant protein

   NAA10 belongs to the acetyltransferase family. NAA10 interacts NAA15, HIF-1 with the ribosome. In its binding to HIF-1, NAA10 acts as a protein acetyltransferase by regulating its stability. In many cell lines, NAA10 is downregulated in response to hypoxia. NAA10 is expressed throughout the development of the brain. Recombinant human NAA10 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.
 Product Categories/Family for NAA10 recombinant protein    Metabolism
 Applications Tested/Suitable for NAA10 recombinant protein   


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 SDS-Page of NAA10 recombinant protein    NAA10 recombinant protein SDS-Page image
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NCBI/Uniprot data below describe general gene information for NAA10. It may not necessarily be applicable to this product.
 NCBI GI #    10835057
 NCBI GeneID    8260
 NCBI Accession #    NP_003482 [Other Products]
 NCBI GenBank Nucleotide #    NM_003491.3 [Other Products]
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 UniProt Primary Accession #    P41227 [Other Products]
 UniProt Secondary Accession #    A6NM98 [Other Products]
 UniProt Related Accession #    P41227 [Other Products]
 Molecular Weight    28.6kDa (255aa), confirmed by MALDI-TOF (Molecular weight on SDS-PAGE will appear higher)
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 NCBI Official Full Name    N-alpha-acetyltransferase 10 isoform 1
 NCBI Official Synonym Full Names    N(alpha)-acetyltransferase 10, NatA catalytic subunit
 NCBI Official Symbol    NAA10 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    N-alpha-acetyltransferase 10
 UniProt Protein Name    N-alpha-acetyltransferase 10
 UniProt Synonym Protein Names   
N-terminal acetyltransferase complex ARD1 subunit homolog A; hARD1
 Protein Family    N-alpha-acetyltransferase
 UniProt Gene Name    NAA10 [Similar Products]
 UniProt Synonym Gene Names    ARD1; ARD1A; TE2; hARD1 [Similar Products]
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 NCBI Summary for NAA10    N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. This process involves the transfer of an acetyl group from acetyl-coenzyme A to the alpha-amino group on a nascent polypeptide and is essential for normal cell function. This gene encodes an N-terminal acetyltransferase that functions as the catalytic subunit of the major amino-terminal acetyltransferase A complex. Mutations in this gene are the cause of Ogden syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
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 UniProt Comments for NAA10    Catalytic subunit of the N-terminal acetyltransferase A (NatA) complex which displays alpha (N-terminal) acetyltransferase activity (PubMed:15496142, PubMed:19826488, PubMed:19420222, PubMed:20145209, PubMed:27708256, PubMed:25489052). Acetylates amino termini that are devoid of initiator methionine (PubMed:19420222). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development. Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (PubMed:12464182). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (PubMed:19826488). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (PubMed:20145209). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (PubMed:27708256). Acts as a negative regulator of sister chromatid cohesion during mitosis (PubMed:27422821).
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Product References and Citations for NAA10 recombinant protein

   Arnesen T., et al. (2005) Biochem. J. 386:433-443; Jeong J.-W., et al. (2002) Cell 111:709-720
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 Research Articles on NAA10    1. Study reports on a total of 12 affected females with four different de novo missense mutations in NAA10 and one inherited mutation in a familial case due to germline mosaicism, thus further expanding themutational and clinical spectrum associated with NAA10 related N-terminal-acetyltransferase deficiency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NAA10 recombinant proteinPathways associated with NAA10 recombinant protein
 Reference Product  PubMed Publications
 NAA15 recombinant protein  >11 publications with NAA10 and NAA15
 NAA11 recombinant protein  >3 publications with NAA10 and NAA11
 HYPK recombinant protein  >2 publications with NAA10 and HYPK
 BCOR recombinant protein  >2 publications with NAA10 and BCOR
 Products by Pathway  Pathway Diagram
 Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway antibodies  Hypoxic And Oxygen Homeostasis Regulation Of HIF-1-alpha Pathway Diagram
Diseases associated with NAA10 recombinant proteinOrgans/Tissues associated with NAA10 recombinant protein
 Disease Name  Pubmed Publications
 OGDEN SYNDROME Antibodies  >9 publications with NAA10 and OGDEN SYNDROME
 Neoplasm Metastasis Antibodies  >6 publications with NAA10 and Neoplasm Metastasis
 Cell Transformation, Neoplastic Antibodies  >3 publications with NAA10 and Cell Transformation, Neoplastic
 Prostatic Diseases Antibodies  >3 publications with NAA10 and Prostatic Diseases
 Congenital Abnormalities Antibodies  >3 publications with NAA10 and Congenital Abnormalities
 Heart Diseases Antibodies  >3 publications with NAA10 and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with NAA10 and Carcinoma, Hepatocellular
 Necrosis Antibodies  >2 publications with NAA10 and Necrosis
 Liver Diseases Antibodies  >2 publications with NAA10 and Liver Diseases
 Urinary Bladder Neoplasms Antibodies  >1 publications with NAA10 and Urinary Bladder Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >9 publications with NAA10 and Lung
 Lymph Antibodies  >5 publications with NAA10 and Lymph
 Blood Antibodies  >5 publications with NAA10 and Blood
 Lymph Node Antibodies  >5 publications with NAA10 and Lymph Node
 Brain Antibodies  >5 publications with NAA10 and Brain
 Prostate Antibodies  >4 publications with NAA10 and Prostate
 Liver Antibodies  >3 publications with NAA10 and Liver
 Thyroid Antibodies  >2 publications with NAA10 and Thyroid
 Kidney Antibodies  >2 publications with NAA10 and Kidney
 Intestine Antibodies  >1 publications with NAA10 and Intestine
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